Search

Your search keyword '"Bányász, Tamás"' showing total 12 results
Start Over Author "Bányász, Tamás" Publisher mdpi ag
12 results on '"Bányász, Tamás"'

1. Selective Inhibition of Cardiac Late Na+ Current Is Based on Fast Offset Kinetics of the Inhibitor

Author

Naveed, Muhammad, primary, Mohammed, Aiman Saleh A., additional, Topal, Leila, additional, Kovács, Zsigmond Máté, additional, Dienes, Csaba, additional, Ovári, József, additional, Szentandrássy, Norbert, additional, Magyar, János, additional, Bányász, Tamás, additional, Prorok, János, additional, Jost, Norbert, additional, Virág, László, additional, Baczkó, István, additional, Varró, András, additional, Nánási, Péter P., additional, and Horváth, Balázs, additional

Published
2023
Full Text
View/download PDF

2. Conductance Changes of Na+ Channels during the Late Na+ Current Flowing under Action Potential Voltage Clamp Conditions in Canine, Rabbit, and Guinea Pig Ventricular Myocytes

Author

Horváth, Balázs, primary, Kovács, Zsigmond M., additional, Dienes, Csaba, additional, Óvári, József, additional, Szentandrássy, Norbert, additional, Magyar, János, additional, Bányász, Tamás, additional, Varró, András, additional, and Nánási, Péter P., additional

Published
2023
Full Text
View/download PDF

3. ABT-333 (Dasabuvir) Increases Action Potential Duration and Provokes Early Afterdepolarizations in Canine Left Ventricular Cells via Inhibition of IKr

Author

Kovács, Zsigmond Máté, primary, Óvári, József, additional, Dienes, Csaba, additional, Magyar, János, additional, Bányász, Tamás, additional, Nánási, Péter P., additional, Horváth, Balázs, additional, Feher, Adam, additional, Varga, Zoltan, additional, and Szentandrássy, Norbert, additional

Published
2023
Full Text
View/download PDF

4. Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 2: TRPM4 in Health and Disease

Author

Dienes, Csaba, Kovács, Zsigmond Máté, Hézső, Tamás, Almássy, János, Magyar, János, Bányász, Tamás, Nánási, Péter P., Horváth, Balázs, and Szentandrássy, Norbert

Subjects
pancreatic β-cell, central nervous system injury, cardiac, TRPM4, Review, neuronal, RS1-441, immune system, Pharmacy and materia medica, SUR1, cancer, Medicine, vascular tone, urinary bladder
Abstract

Transient receptor potential melastatin 4 (TRPM4) is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca2+ sensitive and permeable for monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions; it regulates membrane potential and Ca2+ homeostasis in both excitable and non-excitable cells. This part of the review discusses the currently available knowledge about the physiological and pathophysiological roles of TRPM4 in various tissues. These include the physiological functions of TRPM4 in the cells of the Langerhans islets of the pancreas, in various immune functions, in the regulation of vascular tone, in respiratory and other neuronal activities, in chemosensation, and in renal and cardiac physiology. TRPM4 contributes to pathological conditions such as overactive bladder, endothelial dysfunction, various types of malignant diseases and central nervous system conditions including stroke and injuries as well as in cardiac conditions such as arrhythmias, hypertrophy, and ischemia-reperfusion injuries. TRPM4 claims more and more attention and is likely to be the topic of research in the future.

Published
2022

6. Pharmacological Modulation and (Patho)Physiological Roles of TRPM4 Channel—Part 1: Modulation of TRPM4

Author

Kovács, Zsigmond Máté, Dienes, Csaba, Hézső, Tamás, Almássy, János, Magyar, János, Bányász, Tamás, Nánási, Péter P., Horváth, Balázs, and Szentandrássy, Norbert

Subjects
TRPM4 inhibitor, TRPM4, Review, TRPM4 activator, RS1-441, Pharmacy and materia medica, SUR1, flufenamic acid, antibody, siRNA, Medicine, CBA, 9-phenanthrol
Abstract

Transient receptor potential melastatin 4 is a unique member of the TRPM protein family and, similarly to TRPM5, is Ca2+-sensitive and permeable to monovalent but not divalent cations. It is widely expressed in many organs and is involved in several functions by regulating the membrane potential and Ca2+ homeostasis in both excitable and non-excitable cells. This part of the review discusses the pharmacological modulation of TRPM4 by listing, comparing, and describing both endogenous and exogenous activators and inhibitors of the ion channel. Moreover, other strategies used to study TRPM4 functions are listed and described. These strategies include siRNA-mediated silencing of TRPM4, dominant-negative TRPM4 variants, and anti-TRPM4 antibodies. TRPM4 is receiving more and more attention and is likely to be the topic of research in the future.

Published
2022

8. Late Na+ Current Is [Ca2+]i-Dependent in Canine Ventricular Myocytes

Author

Kiss, Dénes, primary, Horváth, Balázs, additional, Hézső, Tamás, additional, Dienes, Csaba, additional, Kovács, Zsigmond, additional, Topal, Leila, additional, Szentandrássy, Norbert, additional, Almássy, János, additional, Prorok, János, additional, Virág, László, additional, Bányász, Tamás, additional, Varró, András, additional, Nánási, Péter P., additional, and Magyar, János, additional

Published
2021
Full Text
View/download PDF

9. Electrophysiological Effects of the Transient Receptor Potential Melastatin 4 Channel Inhibitor (4-Chloro-2-(2-chlorophenoxy)acetamido) Benzoic Acid (CBA) in Canine Left Ventricular Cardiomyocytes

Author

Dienes, Csaba, primary, Hézső, Tamás, additional, Kiss, Dénes Zsolt, additional, Baranyai, Dóra, additional, Kovács, Zsigmond Máté, additional, Szabó, László, additional, Magyar, János, additional, Bányász, Tamás, additional, Nánási, Péter P., additional, Horváth, Balázs, additional, Gönczi, Mónika, additional, and Szentandrássy, Norbert, additional

Published
2021
Full Text
View/download PDF

12. Selective Inhibition of Cardiac Late Na + Current Is Based on Fast Offset Kinetics of the Inhibitor.

Author

Naveed M, Mohammed ASA, Topal L, Kovács ZM, Dienes C, Ovári J, Szentandrássy N, Magyar J, Bányász T, Prorok J, Jost N, Virág L, Baczkó I, Varró A, Nánási PP, and Horváth B

Abstract

The present study was designed to test the hypothesis that the selectivity of blocking the late Na + current (I NaL ) over the peak Na + current (I NaP ) is related to the fast offset kinetics of the Na + channel inhibitor. Therefore, the effects of 1 µM GS967 (I NaL inhibitor), 20 µM mexiletine (I/B antiarrhythmic) and 10 µM quinidine (I/A antiarrhythmic) on I NaL and I NaP were compared in canine ventricular myocardium. I NaP was estimated as the maximum velocity of action potential upstroke (V + max ). Equal amounts of I NaL were dissected by the applied drug concentrations under APVC conditions. The inhibition of I NaL by mexiletine and quinidine was comparable under a conventional voltage clamp, while both were smaller than the inhibitory effect of GS967. Under steady-state conditions, the V + max block at the physiological cycle length of 700 ms was 2.3% for GS967, 11.4% for mexiletine and 26.2% for quinidine. The respective offset time constants were 110 ± 6 ms, 456 ± 284 ms and 7.2 ± 0.9 s. These results reveal an inverse relationship between the offset time constant and the selectivity of I NaL over I NaP inhibition without any influence of the onset rate constant. It is concluded that the selective inhibition of I NaL over I NaP is related to the fast offset kinetics of the Na + channel inhibitor.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results