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8 results on '"Buffardi, Salvatore"'

1. Prospective Evaluation of Different Methods for Volumetric Analysis on [18F]FDG PET/CT in Pediatric Hodgkin Lymphoma

Author

Lopci, Egesta, primary, Elia, Caterina, additional, Catalfamo, Barbara, additional, Burnelli, Roberta, additional, De Re, Valli, additional, Mussolin, Lara, additional, Piccardo, Arnoldo, additional, Cistaro, Angelina, additional, Borsatti, Eugenio, additional, Zucchetta, Pietro, additional, Bianchi, Maurizio, additional, Buffardi, Salvatore, additional, Farruggia, Piero, additional, Garaventa, Alberto, additional, Sala, Alessandra, additional, Vinti, Luciana, additional, Mauz-Koerholz, Christine, additional, and Mascarin, Maurizio, additional

Published
2022
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2. Quantitative Plasma Proteomics to Identify Candidate Biomarkers of Relapse in Pediatric/Adolescent Hodgkin Lymphoma

Author

Repetto, Ombretta, primary, Caggiari, Laura, additional, De Zorzi, Mariangela, additional, Elia, Caterina, additional, Mussolin, Lara, additional, Buffardi, Salvatore, additional, Pillon, Marta, additional, Muggeo, Paola, additional, Casini, Tommaso, additional, Steffan, Agostino, additional, Mauz-Körholz, Christine, additional, Mascarin, Maurizio, additional, and De Re, Valli, additional

Published
2022
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3. Outcome of Children and Adolescents with Recurrent Classical Hodgkin Lymphoma: The Italian Experience

Author

Garaventa, Alberto, primary, Parodi, Stefano, additional, Guerrini, Giulia, additional, Farruggia, Piero, additional, Sala, Alessandra, additional, Pillon, Marta, additional, Buffardi, Salvatore, additional, Rossi, Francesca, additional, Bianchi, Maurizio, additional, Zecca, Marco, additional, Vinti, Luciana, additional, Facchini, Elena, additional, Casini, Tommaso, additional, Bernasconi, Sayla, additional, Amoroso, Loredana, additional, D’Amico, Salvatore, additional, Provenzi, Massimo, additional, De Santis, Raffaela, additional, Sau, Antonella, additional, Muggeo, Paola, additional, Mura, Rosa Maria, additional, Haupt, Riccardo, additional, Mascarin, Maurizio, additional, and Burnelli, Roberta, additional

Published
2022
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4. Prognostic Role of Minimal Disseminated Disease and NOTCH1/FBXW7 Mutational Status in Children with Lymphoblastic Lymphoma: The AIEOP Experience

Author

Lovisa, Federica, primary, Gallingani, Ilaria, additional, Varotto, Elena, additional, Pasin, Cristiano, additional, Carraro, Elisa, additional, Michielotto, Barbara, additional, Garbin, Anna, additional, Damanti, Carlotta Caterina, additional, Pizzi, Marco, additional, d’Amore, Emanuele S. G., additional, Piglione, Matilde, additional, Muggeo, Paola, additional, Buffardi, Salvatore, additional, Vinti, Luciana, additional, Folsi, Veronica Maria, additional, Onofrillo, Daniela, additional, Biffi, Alessandra, additional, Buldini, Barbara, additional, Pillon, Marta, additional, and Mussolin, Lara, additional

Published
2021
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5. Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

Author

Repetto, Ombretta, primary, Lovisa, Federica, additional, Elia, Caterina, additional, Enderle, Daniel, additional, Romanato, Filippo, additional, Buffardi, Salvatore, additional, Sala, Alessandra, additional, Pillon, Marta, additional, Steffan, Agostino, additional, Burnelli, Roberta, additional, Mussolin, Lara, additional, Mascarin, Maurizio, additional, and De Re, Valli, additional

Published
2021
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6. Comparison of Hodgkin’s Lymphoma in Children and Adolescents. A Twenty Year Experience with MH’96 and LH2004 AIEOP (Italian Association of Pediatric Hematology and Oncology) Protocols

Author

Burnelli, Roberta, primary, Fiumana, Giulia, additional, Rondelli, Roberto, additional, Pillon, Marta, additional, Sala, Alessandra, additional, Garaventa, Alberto, additional, D’Amore, Emanuele S.G., additional, Sabattini, Elena, additional, Buffardi, Salvatore, additional, Bianchi, Maurizio, additional, Vinti, Luciana, additional, Zecca, Marco, additional, Muggeo, Paola, additional, Provenzi, Massimo, additional, Farruggia, Piero, additional, Rossi, Francesca, additional, D’Amico, Salvatore, additional, Facchini, Elena, additional, Bernasconi, Sayla, additional, De Santis, Raffaela, additional, Casini, Tommaso, additional, Porta, Fulvio, additional, D’Alba, Irene, additional, Mura, Rosamaria, additional, Verzegnassi, Federico, additional, Sau, Antonella, additional, Cesaro, Simone, additional, Perruccio, Katia, additional, Cellini, Monica, additional, Bertolini, Patrizia, additional, Sperlì, Domenico, additional, Pericoli, Roberta, additional, Galimberti, Daniela, additional, Civino, Adele, additional, and Mascarin, Maurizio, additional

Published
2020
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8. Prospective Evaluation of Different Methods for Volumetric Analysis on [ 18 F]FDG PET/CT in Pediatric Hodgkin Lymphoma.

Author

Lopci E, Elia C, Catalfamo B, Burnelli R, De Re V, Mussolin L, Piccardo A, Cistaro A, Borsatti E, Zucchetta P, Bianchi M, Buffardi S, Farruggia P, Garaventa A, Sala A, Vinti L, Mauz-Koerholz C, and Mascarin M

Abstract

Rationale: Therapy response evaluation by 18F-fluorodeoxyglucose PET/CT (FDG PET) has become a powerful tool for the discrimination of responders from non-responders in pediatric Hodgkin lymphoma (HL). Recently, volumetric analyses have been regarded as a valuable tool for disease prognostication and biological characterization in cancer. Given the multitude of methods available for volumetric analysis in HL, the AIEOP Hodgkin Lymphoma Study Group has designed a prospective analysis of the Italian cohort enrolled in the EuroNet-PHL-C2 trial. Methods: Primarily, the study aimed to compare the different segmentation techniques used for volumetric assessment in HL patients at baseline (PET1) and during therapy: early (PET2) and late assessment (PET3). Overall, 50 patients and 150 scans were investigated for the current analysis. A dedicated software was used to semi-automatically delineate contours of the lesions by using different threshold methods. More specifically, four methods were applied: (1) fixed 41% threshold of the maximum standardized uptake value (SUVmax) within the respective lymphoma site (V41%), (2) fixed absolute SUV threshold of 2.5 (V2.5); (3) SUVmax(lesion)/SUVmean liver >1.5 (Vliver); (4) adaptive method (AM). All parameters obtained from the different methods were analyzed with respect to response. Results: Among the different methods investigated, the strongest correlation was observed between AM and Vliver (rho > 0.9; p < 0.001 for SUVmean, MTV and TLG at all scan timing), along with V2.5 and AM or Vliver (rho 0.98, p < 0.001 for TLG at baseline; rho > 0.9; p < 0.001 for SUVmean, MTV and TLG at PET2 and PET3, respectively). To determine the best segmentation method, we applied logistic regression and correlated different results with Deauville scores at late evaluation. Logistic regression demonstrated that MTV (metabolic tumor volume) and TLG (total lesion glycolysis) computation according to V2.5 and Vliver significantly correlated to response to treatment (p = 0.01 and 0.04 for MTV and 0.03 and 0.04 for TLG, respectively). SUVmean also resulted in significant correlation as absolute value or variation. Conclusions: The best correlation for volumetric analysis was documented for AM and Vliver, followed by V2.5. The volumetric analyses obtained from V2.5 and Vliver significantly correlated to response to therapy, proving to be preferred thresholds in our pediatric HL cohort.

Published
2022
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