1. Randomized Double-Blind Controlled Trial on the Effect of Proteins with Different Tryptophan/Large Neutral Amino Acid Ratios on Sleep in Adolescents: The PROTMORPHEUS Study
- Author
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Freddy Maso, Emmanuelle Rochette, Oussama Saidi, Fabien Andrieux, Stéphane Walrand, Pascale Duché, Eric Doré, Etienne Merlin, Julien Raoux, Bruno Pereira, Maria Livia Fantini, Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions, Université Blaise Pascal (Clermont Ferrand 2) (UBP), Centre de Recherche en Nutrition Humaine d'Auvergne [Clermont-Ferrand] (CRNH Auvergne), CHU Clermont-Ferrand, Unité CRECHE, Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Toulon (UTLN), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Université Clermont Auvergne (UCA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ECREIN UMR1019, Université Clermont Auvergne (UCA), Unité de Biostatistiques, Direction de la Recherche Clinique (DRCI), Centre Hospitalier Universitaire de Clermont-Ferrand, Region Auvergne-Rhone-AlpesRegion Bourgogne-Franche-ComteRegion Hauts-de-FranceRegion Nouvelle-AquitaineEuropean Union (EU) DRV_SIP_2019-012_protmorpheus, Université Clermont Auvergne (UCA)-CHU Clermont-Ferrand, Impact de l'Activité Physique sur la Santé (IAPS), and Rochette, Emmanuelle
- Subjects
Male ,Pediatric Obesity ,DLMO ,Physiology ,law.invention ,0302 clinical medicine ,Randomized controlled trial ,law ,media_common ,Slow-wave sleep ,2. Zero hunger ,youth ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Nutrition and Dietetics ,Tryptophan ,Electroencephalography ,Sleep in non-human animals ,Circadian Rhythm ,3. Good health ,Amino Acids, Neutral ,nutrition ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Dietary Proteins ,lcsh:Nutrition. Foods and food supply ,Adolescent ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,pediatrics ,media_common.quotation_subject ,lcsh:TX341-641 ,Article ,03 medical and health sciences ,Double-Blind Method ,medicine ,Humans ,slow wave sleep ,Circadian rhythm ,business.industry ,Appetite ,030229 sport sciences ,medicine.disease ,Obesity ,Clinical trial ,Athletes ,Sleep ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,metabolism ,030217 neurology & neurosurgery ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Food Science - Abstract
Disturbed sleep is common in adolescents. Ingested nutrients help regulate the internal clock and influence sleep quality. The purpose of this clinical trial is to assess the effect of protein tryptophan (Trp)/large neutral amino acids (LNAAs) ratio on sleep and circadian rhythm. Ingested Trp is involved in the regulation of the sleep/wake cycle and improvement of sleep quality. Since Trp transport through the blood&ndash, brain barrier is competing with LNAAs, protein with higher Trp/LNAAs were expected to increase sleep efficiency. This randomized double-blind controlled trial will enroll two samples of male adolescents predisposed to sleep disturbances: elite rugby players (n = 24) and youths with obesity (n = 24). They will take part randomly in three sessions each held over a week. They will undergo a washout period, when dietary intake will be calibrated (three days), followed by an intervention period (three days), when their diet will be supplemented with three proteins with different Trp/LNAAs ratios. Physical, cognitive, dietary intake, appetite, and sleepiness evaluations will be made on the last day of each session. The primary outcome is sleep efficiency measured through in-home electroencephalogram recordings. Secondary outcomes include sleep staging, circadian phase, and sleep-, food intake-, metabolism-, and inflammation-related biochemical markers. A fuller understanding of the effect of protein Trp/LNAAs ratio on sleep could help in developing nutritional strategies addressing sleep disturbances.
- Published
- 2020