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20 results on '"COPPOLINO, GIUSEPPE"'

3. Childhood Obesity: Insight into Kidney Involvement

Author

Carullo, Nazareno, primary, Zicarelli, Mariateresa, additional, Michael, Ashour, additional, Faga, Teresa, additional, Battaglia, Yuri, additional, Pisani, Antonio, additional, Perticone, Maria, additional, Costa, Davide, additional, Ielapi, Nicola, additional, Coppolino, Giuseppe, additional, Bolignano, Davide, additional, Serra, Raffaele, additional, and Andreucci, Michele, additional

Published
2023
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5. Circulating miRNA 122-5p Expression Predicts Mortality and Cardiovascular Events in Chronic Hemodialysis Patients: A Multicentric, Pilot, Prospective Study

Author

Duni, Anila, primary, Greco, Marta, additional, Presta, Pierangela, additional, Arena, Roberta, additional, Pappas, Ethymios, additional, Lakkas, Lampros, additional, Naka, Katerina K., additional, Brunetti, Antonio, additional, Foti, Daniela Patrizia, additional, Andreucci, Michele, additional, Coppolino, Giuseppe, additional, Dounousi, Evangelia, additional, and Bolignano, Davide, additional

Published
2023
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6. Indirect Effects of the COVID-19 Pandemic on In-Hospital Outcomes among Internal Medicine Departments: A Double-Center Retrospective Study

Author

Di Marco, Maurizio, primary, Miano, Nicoletta, additional, Marchisello, Simona, additional, Coppolino, Giuseppe, additional, L’Episcopo, Giuseppe, additional, Scilletta, Sabrina, additional, Spichetti, Concetta, additional, Torre, Serena, additional, Scicali, Roberto, additional, Zanoli, Luca, additional, Gaudio, Agostino, additional, Castellino, Pietro, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, and Di Pino, Antonino, additional

Published
2023
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7. Urinary Marinobufagenin in Patients with Non-Advanced Chronic Kidney Disease: A Cross-Sectional Study

Author

Bolignano, Davide, primary, Greco, Marta, additional, D’Agostino, Mario, additional, Cianfrone, Paola, additional, Tripodi, Loredana, additional, Misiti, Roberta, additional, Zicarelli, Mariateresa, additional, Ganino, Ludovica, additional, Foti, Daniela Patrizia, additional, Andreucci, Michele, additional, and Coppolino, Giuseppe, additional

Published
2023
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9. Update on Diabetic Kidney Disease (DKD): Focus on Non-Albuminuric DKD and Cardiovascular Risk

Author

Scilletta, Sabrina, primary, Di Marco, Maurizio, additional, Miano, Nicoletta, additional, Filippello, Agnese, additional, Di Mauro, Stefania, additional, Scamporrino, Alessandra, additional, Musmeci, Marco, additional, Coppolino, Giuseppe, additional, Di Giacomo Barbagallo, Francesco, additional, Bosco, Giosiana, additional, Scicali, Roberto, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, and Di Pino, Antonino, additional

Published
2023
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11. Controlling Nutritional Status (CONUT) Score as a Potential Prognostic Indicator of In-Hospital Mortality, Sepsis and Length of Stay in an Internal Medicine Department

Author

Miano, Nicoletta, primary, Di Marco, Maurizio, additional, Alaimo, Salvatore, additional, Coppolino, Giuseppe, additional, L’Episcopo, Giuseppe, additional, Leggio, Stefano, additional, Scicali, Roberto, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, and Di Pino, Antonino, additional

Published
2023
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12. miRNAs in Uremic Cardiomyopathy: A Comprehensive Review

Author

D’Agostino, Mario, primary, Mauro, Davide, additional, Zicarelli, Mariateresa, additional, Carullo, Nazareno, additional, Greco, Marta, additional, Andreucci, Michele, additional, Coppolino, Giuseppe, additional, and Bolignano, Davide, additional

Published
2023
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13. Circulating Omentin-1, Sustained Inflammation and Hyperphosphatemia at the Interface of Subclinical Atherosclerosis in Chronic Kidney Disease Patients on Chronic Renal Replacement Therapy

Author

Bolignano, Davide, primary, Greco, Marta, additional, Arcidiacono, Valentina, additional, Presta, Pierangela, additional, Caglioti, Alfredo, additional, Andreucci, Michele, additional, Dragone, Francesco, additional, Foti, Daniela Patrizia, additional, and Coppolino, Giuseppe, additional

Published
2022
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14. Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes

Author

Di Marco, Maurizio, primary, Urbano, Francesca, additional, Filippello, Agnese, additional, Di Mauro, Stefania, additional, Scamporrino, Alessandra, additional, Miano, Nicoletta, additional, Coppolino, Giuseppe, additional, L’Episcopo, Giuseppe, additional, Leggio, Stefano, additional, Scicali, Roberto, additional, Piro, Salvatore, additional, Purrello, Francesco, additional, and Di Pino, Antonino, additional

Published
2022
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15. Role of Vitamin K in Chronic Kidney Disease: A Focus on Bone and Cardiovascular Health

Author

Bellone, Federica, primary, Cinquegrani, Maria, additional, Nicotera, Ramona, additional, Carullo, Nazareno, additional, Casarella, Alessandro, additional, Presta, Pierangela, additional, Andreucci, Michele, additional, Squadrito, Giovanni, additional, Mandraffino, Giuseppe, additional, Prunestì, Marcello, additional, Vocca, Cristina, additional, De Sarro, Giovambattista, additional, Bolignano, Davide, additional, and Coppolino, Giuseppe, additional

Published
2022
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16. Hypoxia-Inducible Factor Stabilizers in End Stage Kidney Disease: “Can the Promise Be Kept?”

Author

Crugliano, Giuseppina, primary, Serra, Raffaele, additional, Ielapi, Nicola, additional, Battaglia, Yuri, additional, Coppolino, Giuseppe, additional, Bolignano, Davide, additional, Bracale, Umberto Marcello, additional, Pisani, Antonio, additional, Faga, Teresa, additional, Michael, Ashour, additional, Provenzano, Michele, additional, and Andreucci, Michele, additional

Published
2021
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18. Hypoxia-Inducible Factor Stabilizers in End Stage Kidney Disease: 'Can the Promise Be Kept?'

Author

Yuri Battaglia, Michele Andreucci, Davide Bolignano, Ashour Michael, Giuseppina Crugliano, Giuseppe Coppolino, Michele Provenzano, Nicola Ielapi, Teresa Faga, Antonio Pisani, Raffaele Serra, Umberto Bracale, Crugliano, Giuseppina, Serra, Raffaele, Ielapi, Nicola, Battaglia, Yuri, Coppolino, Giuseppe, Bolignano, Davide, Bracale, Umberto Marcello, Pisani, Antonio, Faga, Teresa, Michael, Ashour, Provenzano, Michele, and Andreucci, Michele

Subjects
renal failure, medicine.medical_treatment, Review, Gastroenterology, Kidney Failure, renal disease, hemic and lymphatic diseases, Renal Insufficiency, Chronic, Biology (General), Spectroscopy, Anemia, Iron-Deficiency, treatment, General Medicine, Iron deficiency, anemia, Computer Science Applications, Chemistry, Hypoxia-inducible factors, erythropoietin, Glomerular Filtration Rate, medicine.drug, medicine.medical_specialty, Anemia, QH301-705.5, Iron, Renal function, Chronic kidney disease, Erythropoietin, ESAs, Renal disease, Renal failure, Treatment, Catalysis, Inorganic Chemistry, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Dialysis, business.industry, Organic Chemistry, Prolyl-Hydroxylase Inhibitors, Iron-Deficiency, medicine.disease, Hematinics, Kidney Failure, Chronic, Hemoglobin, business, chronic kidney disease, Kidney disease
Abstract

Anemia is a common complication of chronic kidney disease (CKD). The prevalence of anemia in CKD strongly increases as the estimated Glomerular Filtration Rate (eGFR) decreases. The pathophysiology of anemia in CKD is complex. The main causes are erythropoietin (EPO) deficiency and functional iron deficiency (FID). The administration of injectable preparations of recombinant erythropoiesis-stimulating agents (ESAs), especially epoetin and darbepoetin, coupled with oral or intravenous(iv) iron supplementation, is the current treatment for anemia in CKD for both dialysis and non-dialysis patients. This approach reduces patients’ dependence on transfusion, ensuring the achievement of optimal hemoglobin target levels. However, there is still no evidence that treating anemia with ESAs can significantly reduce the risk of cardiovascular events. Meanwhile, iv iron supplementation causes an increased risk of allergic reactions, gastrointestinal side effects, infection, and cardiovascular events. Currently, there are no studies defining the best strategy for using ESAs to minimize possible risks. One class of agents under evaluation, known as prolyl hydroxylase inhibitors (PHIs), acts to stabilize hypoxia-inducible factor (HIF) by inhibiting prolyl hydroxylase (PH) enzymes. Several randomized controlled trials showed that HIF-PHIs are almost comparable to ESAs. In the era of personalized medicine, it is possible to envisage and investigate specific contexts of the application of HIF stabilizers based on the individual risk profile and mechanism of action.

Published
2021

19. Selenoprotein P-1 (SEPP1) as an Early Biomarker of Myocardial Injury in Patients Undergoing Cardiopulmonary Bypass.

Author

Serraino GF, Bolignano D, Jiritano F, Coppolino G, Napolitano D, Zicarelli M, Pizzini P, Cutrupi S, Testa A, Spoto B, Andreucci M, Mastroroberto P, and Serra R

Abstract

Background : Biomarkers development for prognostication or prediction of perioperative myocardial disease is critical for the evolution of treatment options in patients undergoing cardiac surgery. The aim of our prospective monocentric study was to investigate the role of selenoprotein 1 (SEEP 1) as a potential biomarker for assessing the risk of myocardial injury after cardiac surgery. Methods : Circulating SEPP1 was measured in the blood of 45 patients before surgery and at 4 h, 8 h and 12 h after CPB by enzyme-linked immunosorbent assay (ELISA); (3) Results : circulating SEPP-1 levels measured 4 h after surgery were strongly correlated with CK-MB levels measured at 48 h (R = 0.598, p < 0.0001) and at 72 h (R = 0.308, p = 0.05). Close correlations were also found between 4 h SEPP-1 and Hs-c troponin values measured at 24 h (R = 0.532, p < 0.0001), 48 h (R = 0.348, p = 0.01) and 72 h (R = 0.377, p = 0.02), as well as with cardiopulmonary bypass (CPB) (R = 0.389, p = 0.008) and cross-clamp time (R = 0.374, p = 0.001); (4) Conclusions : Early SEPP1 measurement after CPB may hold great potential for identifying cardiac surgery patients at risk of developing perioperative myocardial injury.

Published
2024
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20. A Rare Complication of Ascariasis: A Case of Acute Interstitial Nephritis.

Author

Carullo N, Divenuto F, Marascio N, Adams NJ, Giancotti A, Comi N, Faga T, Bolignano D, Coppolino G, Serapide F, Costa C, Torti C, Matera G, Quirino A, and Andreucci M

Abstract

Acute interstitial nephritis (AIN) due to helminths is a rare cause of acute kidney injury (AKI). Helminthiases often progresses insidiously, making diagnosis difficult. This was the case of a 72-year-old man, who presented with renal failure, itching and diarrhoea. Urinalysis revealed leukocyturia, microhaematuria and mild proteinuria. A full blood count revealed leucocytosis with eosinophilia. A stool parasitological examination revealed fertilised eggs of Ascaris lumbricoides. Tubulointerstitial nephropathy secondary to A. lumbricoides infection was suspected. A percutaneous renal biopsy was not performed since the patient refused the anti-platelet therapy discontinuation. Mebendazole, albendazole and prednisone therapy was administered. After worm eradiation and discharge, recovery from the parasitosis, absence of pruritus and eosinophilia, and progressive improvement of renal function were observed, strongly suggesting a causal relationship between Ascaris infection and AIN. Parasite infection should be considered in the differential diagnosis of unexplained renal failure because early diagnosis and treatment are necessary to avoid irreversible complications.

Published
2023
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