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14 results on '"Constantinescu, Catalin"'

9. Short-Pulse Lasers: A Versatile Tool in Creating Novel Nano-/Micro-Structures and Compositional Analysis for Healthcare and Wellbeing Challenges

Author

Al-Kattan, Ahmed, primary, Grojo, David, additional, Drouet, Christophe, additional, Mouskeftaras, Alexandros, additional, Delaporte, Philippe, additional, Casanova, Adrien, additional, Robin, Jérôme D., additional, Magdinier, Frédérique, additional, Alloncle, Patricia, additional, Constantinescu, Catalin, additional, Motto-Ros, Vincent, additional, and Hermann, Jörg, additional

Published
2021
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10. B Cells versus T Cells in the Tumor Microenvironment of Malignant Lymphomas. Are the Lymphocytes Playing the Roles of Muhammad Ali versus George Foreman in Zaire 1974?

Author

Desmirean, Minodora, primary, Rauch, Sebastian, additional, Jurj, Ancuta, additional, Pasca, Sergiu, additional, Iluta, Sabina, additional, Teodorescu, Patric, additional, Berce, Cristian, additional, Zimta, Alina-Andreea, additional, Turcas, Cristina, additional, Tigu, Adrian-Bogdan, additional, Moldovan, Cristian, additional, Paris, Irene, additional, Steinheber, Jakob, additional, Richlitzki, Cedric, additional, Constantinescu, Catalin, additional, Sigurjonsson, Olafur Eysteinn, additional, Dima, Delia, additional, Petrushev, Bobe, additional, and Tomuleasa, Ciprian, additional

Published
2020
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11. Overview of the Side-Effects of FDA- and/or EMA-Approved Targeted Therapies for the Treatment of Hematological Malignancies

Author

Constantinescu, Catalin, primary, Pasca, Sergiu, additional, Zimta, Alina-Andreea, additional, Tat, Tiberiu, additional, Rus, Ioana, additional, Teodorescu, Patric, additional, Iluta, Sabina, additional, Tanase, Alina, additional, Colita, Anca, additional, Sigurjonsson, Olafur, additional, Einsele, Hermann, additional, and Tomuleasa, Ciprian, additional

Published
2020
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12. The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients

Author

Pasca, Sergiu, primary, Turcas, Cristina, additional, Jurj, Ancuta, additional, Teodorescu, Patric, additional, Iluta, Sabina, additional, Hotea, Ionut, additional, Bojan, Anca, additional, Selicean, Cristina, additional, Fetica, Bogdan, additional, Petrushev, Bobe, additional, Moisoiu, Vlad, additional, Zimta, Alina-Andreea, additional, Sas, Valentina, additional, Constantinescu, Catalin, additional, Zdrenghea, Mihnea, additional, Dima, Delia, additional, and Tomuleasa, Ciprian, additional

Published
2020
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13. Approach to the Adult Acute Lymphoblastic Leukemia Patient.

Author

Sas V, Moisoiu V, Teodorescu P, Tranca S, Pop L, Iluta S, Pasca S, Blag C, Man S, Roman A, Constantinescu C, Rus I, Buse M, Fetica B, Marian M, Selicean C, Berindan-Neagoe I, Petrushev B, Bumbea H, Tanase A, Zdrenghea M, Fuji S, Kitano S, and Tomuleasa C

Abstract

During recent decades, understanding of the molecular mechanisms of acute lymphoblastic leukemia (ALL) has improved considerably, resulting in better risk stratification of patients and increased survival rates. Age, white blood cell count (WBC), and specific genetic abnormalities are the most important factors that define risk groups for ALL. State-of-the-art diagnosis of ALL requires cytological and cytogenetical analyses, as well as flow cytometry and high-throughput sequencing assays. An important aspect in the diagnostic characterization of patients with ALL is the identification of the Philadelphia (Ph) chromosome, which warrants the addition of tyrosine kinase inhibitors (TKI) to the chemotherapy backbone. Data that support the benefit of hematopoietic stem cell transplantation (HSCT) in high risk patient subsets or in late relapse patients are still questioned and have yet to be determined conclusive. This article presents the newly published data in ALL workup and treatment, putting it into perspective for the attending physician in hematology and oncology., Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results

Published
2019
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14. Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician.

Author

Constantinescu C, Bodolea C, Pasca S, Teodorescu P, Dima D, Rus I, Tat T, Achimas-Cadariu P, Tanase A, Tomuleasa C, and Einsele H

Abstract

: The initial management of the hematology patient in a critical state is crucial and poses a great challenge both for the hematologist and the intensive care unit (ICU) physician. After years of clinical practice, there is still a delay in the proper recognition and treatment of critical situations, which leads to late admission to the ICU. There is a much-needed systematic ABC (Airway, Breathing, Circulation) approach for the patients being treated on the wards as well as in the high dependency units because the underlying hematological disorder, as well as disease-related complications, have an increasing frequency. Focusing on score-based decision-making on the wards (Modified Early Warning Score (MEWS), together with Quick Sofa score), active sepsis screening with inflammation markers (C-reactive protein, procalcitonin, and presepsin), and assessment of microcirculation, organ perfusion, and oxygen supply by using paraclinical parameters from the ICU setting (lactate, central venous oxygen saturation (ScVO 2 ), and venous-to-arterial carbon dioxide difference), hematologists can manage the immediate critical patient and improve the overall outcome., Competing Interests: The authors declare no conflict of interest.

Published
2019
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