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17 results on '"Cruz, Gonzalo"'

2. Modulation of Kynurenic Acid Production by N-acetylcysteine Prevents Cognitive Impairment in Adulthood Induced by Lead Exposure during Lactation in Mice

Author

Ovalle Rodríguez, Paulina, primary, Ramírez Ortega, Daniela, additional, Blanco Ayala, Tonali, additional, Roldán Roldán, Gabriel, additional, Pérez de la Cruz, Gonzalo, additional, González Esquivel, Dinora Fabiola, additional, Gómez-Manzo, Saúl, additional, Sánchez Chapul, Laura, additional, Salazar, Aleli, additional, Pineda, Benjamín, additional, and Pérez de la Cruz, Verónica, additional more...

Published
2023
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4. Chronic Exposure to High Fat Diet Affects the Synaptic Transmission That Regulates the Dopamine Release in the Nucleus Accumbens of Adolescent Male Rats

Author

Plaza-Briceño, Wladimir, primary, Velásquez, Victoria B., additional, Silva-Olivares, Francisco, additional, Ceballo, Karina, additional, Céspedes, Ricardo, additional, Jorquera, Gonzalo, additional, Cruz, Gonzalo, additional, Martínez-Pinto, Jonathan, additional, Bonansco, Christian, additional, and Sotomayor-Zárate, Ramón, additional more...

Published
2023
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5. Kynureninase Promotes Immunosuppression and Predicts Survival in Glioma Patients: In Silico Data Analyses of the Chinese Glioma Genome Atlas (CGGA) and of the Cancer Genome Atlas (TCGA)

Author

Pérez de la Cruz, Gonzalo, primary, Pérez de la Cruz, Verónica, additional, Navarro Cossio, Javier, additional, Vázquez Cervantes, Gustavo Ignacio, additional, Salazar, Aleli, additional, Orozco Morales, Mario, additional, and Pineda, Benjamin, additional more...

Published
2023
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6. Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake

Author

Marcos, José Luis, primary, Olivares-Barraza, Rossy, additional, Ceballo, Karina, additional, Wastavino, Melisa, additional, Ortiz, Víctor, additional, Riquelme, Julio, additional, Martínez-Pinto, Jonathan, additional, Muñoz, Pablo, additional, Cruz, Gonzalo, additional, and Sotomayor-Zárate, Ramón, additional more...

Published
2023
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9. Characterization of Redox Environment and Tryptophan Catabolism through Kynurenine Pathway in Military Divers’ and Swimmers’ Serum Samples

Author

Sánchez Chapul, Laura, primary, Pérez de la Cruz, Gonzalo, additional, Ramos Chávez, Lucio Antonio, additional, Valencia León, Jesús F., additional, Torres Beltrán, Joel, additional, Estrada Camarena, Erika, additional, Carillo Mora, Paul, additional, Ramírez Ortega, Daniela, additional, Baños Vázquez, José U., additional, Martínez Nava, Gabriela, additional, Luna Angulo, Alexandra, additional, Martínez Canseco, Carlos, additional, Wences Chirino, Tiffany Y., additional, Ríos Martínez, Juan, additional, and Pérez de la Cruz, Verónica, additional more...

Published
2022
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11. On the Antioxidant Properties of L-Kynurenine: An Efficient ROS Scavenger and Enhancer of Rat Brain Antioxidant Defense

Author

Ramírez Ortega, Daniela, primary, Ugalde Muñiz, Perla Eugenia, additional, Blanco Ayala, Tonali, additional, Vázquez Cervantes, Gustavo Ignacio, additional, Lugo Huitrón, Rafael, additional, Pineda, Benjamín, additional, González Esquivel, Dinora Fabiola, additional, Pérez de la Cruz, Gonzalo, additional, Pedraza Chaverrí, José, additional, Sánchez Chapul, Laura, additional, Gómez-Manzo, Saúl, additional, and Pérez de la Cruz, Verónica, additional more...

Published
2021
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12. Kynurenine Monooxygenase Expression and Activity in Human Astrocytomas

Author

Vázquez Cervantes, Gustavo Ignacio, primary, Pineda, Benjamín, additional, Ramírez Ortega, Daniela, additional, Salazar, Alelí, additional, González Esquivel, Dinora Fabiola, additional, Rembao, Daniel, additional, Zavala Vega, Sergio, additional, Gómez-Manzo, Saúl, additional, Pérez de la Cruz, Gonzalo, additional, and Pérez de la Cruz, Verónica, additional more...

Published
2021
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16. Subchronic N-acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice

Author

Blanco Ayala, Tonali, primary, Ramírez Ortega, Daniela, additional, Ovalle Rodríguez, Paulina, additional, Pineda, Benjamín, additional, Pérez de la Cruz, Gonzalo, additional, González Esquivel, Dinora, additional, Schwarcz, Robert, additional, Sathyasaikumar, Korrapati V., additional, Jiménez Anguiano, Anabel, additional, and Pérez de la Cruz, Verónica, additional more...

Published
2021
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17. Role of NLRP3 Inflammasome in Heart Failure Patients Undergoing Cardiac Surgery as a Potential Determinant of Postoperative Atrial Fibrillation and Remodeling: Is SGLT2 Cotransporter Inhibition an Alternative for Cardioprotection?

Author

Castillo RL, Farías J, Sandoval C, González-Candia A, Figueroa E, Quezada M, Cruz G, Llanos P, Jorquera G, Kostin S, and Carrasco R

Abstract

In heart failure (HF) patients undergoing cardiac surgery, an increased activity of mechanisms related to cardiac remodeling may determine a higher risk of postoperative atrial fibrillation (POAF). Given that atrial fibrillation (AF) has a negative impact on the course and management of HF, including the need for anticoagulation therapy, identifying the factors associated with AF occurrence after cardiac surgery is crucial for the prognosis of these patients. POAF is thought to occur when various clinical and biochemical triggers act on susceptible cardiac tissue (first hit), with oxidative stress and inflammation during cardiopulmonary bypass (CPB) surgery being potential contributing factors (second hit). However, the molecular mechanisms involved in these processes remain poorly characterized. Recent research has shown that patients who later develop POAF often have pre-existing abnormalities in calcium handling and activation of NLRP3-inflammasome signaling in their atrial cardiomyocytes. These molecular changes may make cardiomyocytes more susceptible to spontaneous Ca2+-releases and subsequent arrhythmias, particularly when exposed to inflammatory mediators. Additionally, some clinical studies have linked POAF with elevated preoperative inflammatory markers, but there is a need for further research in order to better understand the impact of CPB surgery on local and systemic inflammation. This knowledge would make it possible to determine whether patients susceptible to POAF have pre-existing inflammatory conditions or cellular electrophysiological factors that make them more prone to developing AF and cardiac remodeling. In this context, the NLRP3 inflammasome, expressed in cardiomyocytes and cardiac fibroblasts, has been identified as playing a key role in the development of HF and AF, making patients with pre-existing HF with reduced ejection fraction (HFrEF) the focus of several clinical studies with interventions that act at this level. On the other hand, HFpEF has been linked to metabolic and non-ischemic risk factors, but more research is needed to better characterize the myocardial remodeling events associated with HFpEF. Therefore, since ventricular remodeling may differ between HFrEF and HFpEF, it is necessary to perform studies in both groups of patients due to their pathophysiological variations. Clinical evidence has shown that pharmacological therapies that are effective for HFrEF may not provide the same anti-remodeling benefits in HFpEF patients, particularly compared to traditional adrenergic and renin-angiotensin-aldosterone system inhibitors. On the other hand, there is growing interest in medications with pleiotropic or antioxidant/anti-inflammatory effects, such as sodium-glucose cotransporter 2 inhibitors (SGLT-2is). These drugs may offer anti-remodeling effects in both HFrEF and HFpEF by inhibiting pro-inflammatory, pro-oxidant, and NLRP3 signaling pathways and their mediators. The anti-inflammatory, antioxidant, and anti-remodeling effects of SGLT-2 i have progressively expanded from HFrEF and HFpEF to other forms of cardiac remodeling. However, these advances in research have not yet encompassed POAF despite its associations with inflammation, oxidative stress, and remodeling. Currently, the direct or indirect effects of NLRP3-dependent pathway inhibition on the occurrence of POAF have not been clinically assessed. However, given that NLRP3 pathway inhibition may also indirectly affect other pathways, such as inhibition of NF-kappaB or inhibition of matrix synthesis, which are strongly linked to POAF and cardiac remodeling, it is reasonable to hypothesize that this type of intervention could play a role in preventing these events. more...

Published
2024
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