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Your search keyword '"Curcio, Rosita"' showing total 16 results
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16 results on '"Curcio, Rosita"'

1. A Picrocrocin-Enriched Fraction from a Saffron Extract Affects Lipid Homeostasis in HepG2 Cells through a Non-Statin-like Mode

Author

Frattaruolo, Luca, primary, Marra, Federica, additional, Lauria, Graziantonio, additional, Siciliano, Carlo, additional, Curcio, Rosita, additional, Muto, Luigina, additional, Brindisi, Matteo, additional, Aiello, Donatella, additional, Napoli, Anna, additional, Fiermonte, Giuseppe, additional, Cappello, Anna Rita, additional, Fiorillo, Marco, additional, Ahmed, Amer, additional, and Dolce, Vincenza, additional

Published
2023
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4. The First Identification in Italy of SARS-CoV-2 Omicron BA.4 Harboring KSF141_del: A Genomic Comparison with Omicron Sub-Variants

Author

Peronace, Cinzia, primary, Tallerico, Rossana, additional, Colosimo, Manuela, additional, Fazio, Marco De, additional, Pasceri, Federica, additional, Talotta, Ilenia, additional, Panduri, Giuseppina, additional, Pintomalli, Letizia, additional, Oteri, Rosaria, additional, Calantoni, Valeria, additional, Fiorillo, Maria Teresa, additional, Caroleo, Maria Cristina, additional, Curcio, Rosita, additional, Dolce, Vincenza, additional, Cione, Erika, additional, and Minchella, Pasquale, additional

Published
2022
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5. First Identification in Italy of SARS-CoV-2 Omicron BA.4 Harboring KSF141_del: Genomic Comparison with Omicron Sub-Variants

Author

Peronace, Cinzia, primary, Tallerico, Rossana, additional, Colosimo, Manuela, additional, De Fazio, Marco, additional, Pasceri, Federica, additional, Talotta, Ilenia, additional, Panduri, Giuseppina, additional, Pintomalli, Letizia, additional, Oteri, Rosaria, additional, Calantoni, Valeria, additional, Fiorillo, Maria Teresa, additional, Caroleo, Maria Cristina, additional, Curcio, Rosita, additional, Dolce, Vincenza, additional, Cione, Erika, additional, and Minchella, Pasquale, additional

Published
2022
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12. 5-(Carbamoylmethylene)-oxazolidin-2-ones as a Promising Class of Heterocycles Inducing Apoptosis Triggered by Increased ROS Levels and Mitochondrial Dysfunction in Breast and Cervical Cancer

Author

Armentano, Biagio, primary, Curcio, Rosita, additional, Brindisi, Matteo, additional, Mancuso, Raffaella, additional, Rago, Vittoria, additional, Ziccarelli, Ida, additional, Frattaruolo, Luca, additional, Fiorillo, Marco, additional, Dolce, Vincenza, additional, Gabriele, Bartolo, additional, and Cappello, Anna Rita, additional

Published
2020
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13. Thioalbamide, A Thioamidated Peptide from Amycolatopsis alba, Affects Tumor Growth and Stemness by Inducing Metabolic Dysfunction and Oxidative Stress

Author

Frattaruolo, Luca, primary, Fiorillo, Marco, additional, Brindisi, Matteo, additional, Curcio, Rosita, additional, Dolce, Vincenza, additional, Lacret, Rodney, additional, Truman, Andrew W., additional, Sotgia, Federica, additional, Lisanti, Michael P., additional, and Cappello, Anna Rita, additional

Published
2019
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14. Antioxidant and Anti-Inflammatory Activities of Flavanones from Glycyrrhiza glabra L. (licorice) Leaf Phytocomplexes: Identification of Licoflavanone as a Modulator of NF-kB/MAPK Pathway

Author

Frattaruolo, Luca, primary, Carullo, Gabriele, additional, Brindisi, Matteo, additional, Mazzotta, Sarah, additional, Bellissimo, Luca, additional, Rago, Vittoria, additional, Curcio, Rosita, additional, Dolce, Vincenza, additional, Aiello, Francesca, additional, and Cappello, Anna Rita, additional

Published
2019
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15. Drosophila melanogaster Uncoupling Protein-4A (UCP4A) Catalyzes a Unidirectional Transport of Aspartate

Author

Paola Lunetti, Ruggiero Gorgoglione, Rosita Curcio, Federica Marra, Antonella Pignataro, Angelo Vozza, Christopher L. Riley, Loredana Capobianco, Luigi Palmieri, Vincenza Dolce, Giuseppe Fiermonte, Lunetti, Paola, Gorgoglione, Ruggiero, Curcio, Rosita, Marra, Federica, Pignataro, Antonella, Vozza, Angelo, Riley, Christopher L., Capobianco, Loredana, Palmieri, Luigi, Dolce, Vincenza, and Fiermonte, Giuseppe

Subjects
QH301-705.5, ß-alanine, Organic Chemistry, uncoupling proteins, uncoupling proteins, DmUCP4A, mitochondrial transporters, aspartate transport, alanine, biogenic amines metabolism, Parkinson’s disease, CG6492, mitochondrial carrier family, N-acetylaspartate, DmUCP4A, mitochondrial transporters, aspartate transport, biogenic amines metabolism, Parkinson’s disease, CG6492, mitochondrial carrier family, N-acetylaspartate, General Medicine, Catalysis, Computer Science Applications, Inorganic Chemistry, Chemistry, Biology (General), Physical and Theoretical Chemistry, QD1-999, Molecular Biology, Spectroscopy
Abstract

Uncoupling proteins (UCPs) form a distinct subfamily of the mitochondrial carrier family (MCF) SLC25. Four UCPs, DmUCP4A-C and DmUCP5, have been identified in Drosophila melanogaster on the basis of their sequence homology with mammalian UCP4 and UCP5. In a Parkinson’s disease model, DmUCP4A showed a protective role against mitochondrial dysfunction, by increasing mitochondrial membrane potential and ATP synthesis. To date, DmUCP4A is still an orphan of a biochemical function, although its possible involvement in mitochondrial uncoupling has been ruled out. Here, we show that DmUCP4A expressed in bacteria and reconstituted in phospholipid vesicles catalyzes a unidirectional transport of aspartate, which is saturable and inhibited by mercurials and other mitochondrial carrier inhibitors to various degrees. Swelling experiments carried out in yeast mitochondria have demonstrated that the unidirectional transport of aspartate catalyzed by DmUCP4 is not proton-coupled. The biochemical function of DmUCP4A has been further confirmed in a yeast cell model, in which growth has required an efflux of aspartate from mitochondria. Notably, DmUCP4A is the first UCP4 homolog from any species to be biochemically characterized. In Drosophila melanogaster, DmUCP4A could be involved in the transport of aspartate from mitochondria to the cytosol, in which it could be used for protein and nucleotide synthesis, as well as in the biosynthesis of ß-alanine and N-acetylaspartate, which play key roles in signal transmission in the central nervous system.

Published
2022

16. An Overview of Mitochondrial Protein Defects in Neuromuscular Diseases

Author

Vito Porcelli, Loredana Capobianco, Giuseppe Fiermonte, Vincenza Dolce, Francesco Massimo Lasorsa, Federica Marra, Rosita Curcio, Paola Lunetti, Pasquale Scarcia, Marra, Federica, Lunetti, Paola, Curcio, Rosita, Lasorsa Francesco, Massimo, Capobianco, Loredana, Porcelli, Vito, Dolce, Vincenza, and Fiermonte Giuseppe and Scarcia, Pasquale

Subjects
mitochondrial metabolism, Cellular homeostasis, neuromuscular diseases, Review, Mitochondrion, Biology, Bioinformatics, Models, Biological, Microbiology, Biochemistry, Electron Transport, Mitochondrial Proteins, medicine, Animals, Humans, Inner mitochondrial membrane, Myopathy, Molecular Biology, therapy, MERF, neuromuscular junction, Muscle weakness, Skeletal muscle, Leigh syndrome, MELAS, Leigh syndrome, OXPHOS, Phenotype, QR1-502, MERF, Mitochondrial carrier family, Mitochondrial metabolism, Myopathy, Neuromuscular diseases, Neuromuscular junction, OXPHOS, Therapy, medicine.anatomical_structure, Mitochondrial biogenesis, MELAS, Mutation, mitochondrial carrier family, medicine.symptom, myopathy
Abstract

Neuromuscular diseases (NMDs) are dysfunctions that involve skeletal muscle and cause incorrect communication between the nerves and muscles. The specific causes of NMDs are not well known, but most of them are caused by genetic mutations. NMDs are generally progressive and entail muscle weakness and fatigue. Muscular impairments can differ in onset, severity, prognosis, and phenotype. A multitude of possible injury sites can make diagnosis of NMDs difficult. Mitochondria are crucial for cellular homeostasis and are involved in various metabolic pathways; for this reason, their dysfunction can lead to the development of different pathologies, including NMDs. Most NMDs due to mitochondrial dysfunction have been associated with mutations of genes involved in mitochondrial biogenesis and metabolism. This review is focused on some mitochondrial routes such as the TCA cycle, OXPHOS, and β-oxidation, recently found to be altered in NMDs. Particular attention is given to the alterations found in some genes encoding mitochondrial carriers, proteins of the inner mitochondrial membrane able to exchange metabolites between mitochondria and the cytosol. Briefly, we discuss possible strategies used to diagnose NMDs and therapies able to promote patient outcome.

Published
2021

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