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4. Prospective Evaluation of Different Methods for Volumetric Analysis on [18F]FDG PET/CT in Pediatric Hodgkin Lymphoma

Author

Lopci, Egesta, primary, Elia, Caterina, additional, Catalfamo, Barbara, additional, Burnelli, Roberta, additional, De Re, Valli, additional, Mussolin, Lara, additional, Piccardo, Arnoldo, additional, Cistaro, Angelina, additional, Borsatti, Eugenio, additional, Zucchetta, Pietro, additional, Bianchi, Maurizio, additional, Buffardi, Salvatore, additional, Farruggia, Piero, additional, Garaventa, Alberto, additional, Sala, Alessandra, additional, Vinti, Luciana, additional, Mauz-Koerholz, Christine, additional, and Mascarin, Maurizio, additional

Published
2022
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5. Quantitative Plasma Proteomics to Identify Candidate Biomarkers of Relapse in Pediatric/Adolescent Hodgkin Lymphoma

Author

Repetto, Ombretta, primary, Caggiari, Laura, additional, De Zorzi, Mariangela, additional, Elia, Caterina, additional, Mussolin, Lara, additional, Buffardi, Salvatore, additional, Pillon, Marta, additional, Muggeo, Paola, additional, Casini, Tommaso, additional, Steffan, Agostino, additional, Mauz-Körholz, Christine, additional, Mascarin, Maurizio, additional, and De Re, Valli, additional

Published
2022
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6. HER2–CDH1 Interaction via Wnt/B-Catenin Is Associated with Patients’ Survival in HER2-Positive Metastatic Gastric Adenocarcinoma

Author

De Re, Valli, primary, Alessandrini, Lara, additional, Brisotto, Giulia, additional, Caggiari, Laura, additional, De Zorzi, Mariangela, additional, Casarotto, Mariateresa, additional, Miolo, Gianmaria, additional, Puglisi, Fabio, additional, Garattini, Silvio Ken, additional, Lonardi, Sara, additional, Cannizzaro, Renato, additional, Canzonieri, Vincenzo, additional, Fassan, Matteo, additional, and Steffan, Agostino, additional

Published
2022
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7. Proteomic Exploration of Plasma Exosomes and Other Small Extracellular Vesicles in Pediatric Hodgkin Lymphoma: A Potential Source of Biomarkers for Relapse Occurrence

Author

Repetto, Ombretta, primary, Lovisa, Federica, additional, Elia, Caterina, additional, Enderle, Daniel, additional, Romanato, Filippo, additional, Buffardi, Salvatore, additional, Sala, Alessandra, additional, Pillon, Marta, additional, Steffan, Agostino, additional, Burnelli, Roberta, additional, Mussolin, Lara, additional, Mascarin, Maurizio, additional, and De Re, Valli, additional

Published
2021
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10. Overview of Epstein–Barr-Virus-Associated Gastric Cancer Correlated with Prognostic Classification and Development of Therapeutic Options

Author

De Re, Valli, primary, Brisotto, Giulia, additional, Repetto, Ombretta, additional, De Zorzi, Mariangela, additional, Caggiari, Laura, additional, Zanussi, Stefania, additional, Alessandrini, Lara, additional, Canzonieri, Vincenzo, additional, Miolo, Gianmaria, additional, Puglisi, Fabio, additional, Belluco, Claudio, additional, Steffan, Agostino, additional, and Cannizzaro, Renato, additional

Published
2020
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14. Carcinogenesis and Metastasis in Liver: Cell Physiological Basis

Author

Rossetto, Anna, primary, De Re, Valli, additional, Steffan, Agostino, additional, Ravaioli, Matteo, additional, Miolo, Gianmaria, additional, Leone, Patrizia, additional, Racanelli, Vito, additional, Uzzau, Alessandro, additional, Baccarani, Umberto, additional, and Cescon, Matteo, additional

Published
2019
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15. BRAF Mutations and Dysregulation of the MAP Kinase Pathway Associated to Sinonasal Mucosal Melanomas

Author

Colombino, Maria, primary, Paliogiannis, Panagiotis, additional, Cossu, Antonio, additional, De Re, Valli, additional, Miolo, Gianmaria, additional, Botti, Gerardo, additional, Scognamiglio, Giosuè, additional, Ascierto, Paolo, additional, Santeufemia, Davide, additional, Fraggetta, Filippo, additional, Manca, Antonella, additional, Sini, Maria, additional, Casula, Milena, additional, Palomba, Grazia, additional, Pisano, Marina, additional, Doneddu, Valentina, additional, Lissia, Amelia, additional, Fedeli, Maria, additional, and Palmieri, Giuseppe, additional

Published
2019
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16. Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk

Author

Casarotto, Mariateresa, primary, Pratesi, Chiara, additional, Bidoli, Ettore, additional, Maiero, Stefania, additional, Magris, Raffaella, additional, Steffan, Agostino, additional, Basaglia, Giancarlo, additional, Canzonieri, Vincenzo, additional, De Re, Valli, additional, Cannizzaro, Renato, additional, and Zanussi, Stefania, additional

Published
2019
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17. Polymorphism in Toll-Like Receptors and Helicobacter Pylori Motility in Autoimmune Atrophic Gastritis and Gastric Cancer

Author

De Re, Valli, primary, Repetto, Ombretta, additional, De Zorzi, Mariangela, additional, Casarotto, Mariateresa, additional, Tedeschi, Massimo, additional, Giuffrida, Paolo, additional, Lenti, Marco Vincenzo, additional, Magris, Raffaella, additional, Miolo, Gianmaria, additional, Mazzon, Cinzia, additional, Zanette, Giorgio, additional, Alessandrini, Lara, additional, Canzonieri, Vincenzo, additional, Caggiari, Laura, additional, Zanussi, Stefania, additional, Steffan, Agostino, additional, Di Sabatino, Antonio, additional, and Cannizzaro, Renato, additional

Published
2019
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24. Characterizing Metastatic HER2-Positive Gastric Cancer at the CDH1 Haplotype

Author

Caggiari, Laura, primary, Miolo, Gianmaria, additional, Buonadonna, Angela, additional, Basile, Debora, additional, Santeufemia, Davide, additional, Cossu, Antonio, additional, Palmieri, Giuseppe, additional, De Zorzi, Mariangela, additional, Fornasarig, Mara, additional, Alessandrini, Lara, additional, Canzonieri, Vincenzo, additional, Lo Re, Giovanni, additional, Puglisi, Fabio, additional, Steffan, Agostino, additional, Cannizzaro, Renato, additional, and De Re, Valli, additional

Published
2017
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25. Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma

Author

Valli De Re, Raffaella Magris, Renato Cannizzaro, Gianmaria Miolo, Agostino Steffan, Ombretta Repetto, Stefania Maiero, Maria Rita Cozzi, Vincenzo Canzonieri, Repetto, Ombretta, Maiero, Stefania, Magris, Raffaella, Miolo, Gianmaria, Cozzi, Maria, Steffan, Agostino, Canzonieri, Vincenzo, Cannizzaro, Renato, and De Re, Valli

Subjects
Male, Proteomics, 0301 basic medicine, Angiogenesis, comparative proteomic, Fibrinogen, Mass Spectrometry, lcsh:Chemistry, 0302 clinical medicine, Electrophoresis, Gel, Two-Dimensional, Platelet, fibrinogen β chain, Databases, Protein, FGB, lcsh:QH301-705.5, Spectroscopy, DIGE, platelet, Gel electrophoresis, Chemistry, General Medicine, Middle Aged, comparative proteomics, gastric cancer, coagulation, platelets, biomarker, Computer Science Applications, Coagulation, 030220 oncology & carcinogenesis, Female, medicine.symptom, Protein Binding, medicine.drug, Adult, Inflammation, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Stomach Neoplasms, medicine, Humans, Physical and Theoretical Chemistry, Molecular Biology, Aged, Carcinoma, Organic Chemistry, fibrinogen beta chain, Computational Biology, Reproducibility of Results, Cancer, medicine.disease, Molecular biology, Protein Subunits, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Tumor progression, Carrier Proteins, Protein Processing, Post-Translational
Abstract

Elevated plasma fibrinogen levels and tumor progression in patients with gastric cancer (GC) have been largely reported. However, distinct fibrinogen chains and domains have different effects on coagulation, inflammation, and angiogenesis. The aim of this study was to characterize fibrinogen beta chain (FGB) in GC tissues. Retrospectively we analyzed the data of matched pairs of normal (N) and malignant tissues (T) of 28 consecutive patients with GC at diagnosis by combining one- and two-dimensional electrophoresis (1DE and 2DE) with immunoblotting and mass spectrometry together with two-dimensional difference in gel electrophoresis (2D-DIGE). 1DE showed bands of the intact FGB at 50 kDa and the cleaved forms containing the fragment D at similar to 37-40 kDa, which corresponded to 19 spots in 2DE. In particular, spot 402 at similar to 50 kDa and spots 526 and 548 at similar to 37 kDa were of interest by showing an increased expression in tumor tissues. A higher content of spot 402 was associated with stomach antrum, while spots 526 and 548 amounts correlated with corpus and high platelet count (>208 x 10(9)/L). The quantification of FGB and cleaved products may help to further characterize the interconnections between GC and platelet/coagulation pathways.

Published
2018

26. Differential Helicobacter pylori Plasticity in the Gastric Niche of Subjects at Increased Gastric Cancer Risk

Author

Stefania Maiero, Agostino Steffan, Mariateresa Casarotto, G. Basaglia, Valli De Re, Ettore Bidoli, Vincenzo Canzonieri, Chiara Pratesi, Stefania Zanussi, Raffaella Magris, Renato Cannizzaro, Casarotto, Mariateresa, Pratesi, Chiara, Bidoli, Ettore, Maiero, Stefania, Magris, Raffaella, Steffan, Agostino, Basaglia, Giancarlo, Canzonieri, Vincenzo, De Re, Valli, Cannizzaro, Renato, and Zanussi, Stefania

Subjects
Microbiology (medical), medicine.medical_specialty, Autoimmune Gastritis, virulence factors, lcsh:Medicine, Virulence, autoimmune gastritis, Gastroenterology, Article, genetic heterogeneity, Atrophy, Internal medicine, Immunology and Allergy, Medicine, CagA, first degree relatives of gastric cancer patient, First-degree relatives, Molecular Biology, autoimmune gastriti, Helicobacter pylori, General Immunology and Microbiology, biology, business.industry, Genetic heterogeneity, gastric cancer, lcsh:R, first degree relatives of gastric cancer patients, bacterial infections and mycoses, medicine.disease, biology.organism_classification, Pathogenicity island, Infectious Diseases, business
Abstract

Helicobacter pylori (H. pylori) represents an independent risk factor for Gastric Cancer (GC). First Degree Relatives (FDR) of GC subjects and Autoimmune Gastritis (AG) patients are both at increased risk for GC. H. pylori genetic heterogeneity within the gastric niche of FDR and AG individuals has been little explored. To understand whether they exploit an increased H. pylori stability and virulence, 14 AG, 25 FDR, 39 GC and 13 dyspeptic patients (D) were investigated by a cultural PCR-based approach characterizing single colonies-forming-units. We chose three loci within the Cytotoxin-associated gene-A Pathogenicity Island (CagPAI) (cagA,cagE,virB11), vacA, homA and homB as markers of virulence with reported association to GC. Inflammatory/precancerous lesions were staged according to Sydney System. When compared to D, FDR, similarly to GC patients, were associated to higher atrophy (OR = 6.29, 95% CI):1.23&ndash, 31.96 in FDR, OR = 7.50, 95% CI:1.67&ndash, 33.72 in GC) and a lower frequency of mixed infections (OR = 0.16, 95% CI:0.03&ndash, 0.81 in FDR, OR = 0.10, 95% CI:0.02&ndash, 0.48 in GC). FDR presented also an increased neutrophil infiltration (OR = 7.19, 95% CI:1.16&ndash, 44.65). Both FDR and GC carried a higher proportion of CagPAI+vacAs1i1mx+homB+ profiles (OR = 2.71, 95% CI: 1.66&ndash, 4.41 and OR = 3.43, 95% CI: 2.16&ndash, 5.44, respectively). Conversely, AG patients presented a lower frequency of subtypes carrying a stable CagPAI and vacAs1i1mx. These results underline different H. pylori plasticity in FDR and AG individuals, and thus, a different host-bacterium interaction capacity that should be considered in the context of eradication therapies.

Published
2019
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27. Preliminary Study of the Relationship between Osteopontin and Relapsed Hodgkin's Lymphoma.

Author

De Re V, Lopci E, Brisotto G, Elia C, Mussolin L, Mascarin M, d'Amore ESG, and Aieop The Hodgkin's Lymphoma Research Network

Abstract

The primary objective of this study was to investigate the potential role of tissue osteopontin, also known as secreted phosphoprotein 1 ( SPP1 ), as a contributing factor to an unfavorable prognosis in classical Hodgkin's lymphoma (HL) patients who received the same treatment protocol. The study involved 44 patients aged 4-22 years, with a median follow-up period of 3 years. Patients with higher levels of SPP1 were associated with tissue necrosis and inflammation, and there was a trend toward a poorer prognosis in this group. Before therapy, we found a correlation between positron emission tomography (PET) scans and logarithmic SPP1 levels ( p = 0.035). However, the addition of SPP1 levels did not significantly enhance the predictive capacity of PET scans for recurrence or progression. Elevated SPP levels were associated with tissue mRNA counts of chemotactic and inflammatory chemokines, as well as specific monocyte/dendritic cell subtypes, defined by IL-17RB, PLAUR, CXCL8, CD1A, CCL13, TREM1 , and CCL24 markers. These findings contribute to a better understanding of the potential factors influencing the prognosis of HL patients and the potential role of SPP1 in the disease. While the predictive accuracy of PET scans did not substantially improve during the study, the results underscore the complexity of HL and highlight the relationships between SPP1 and other factors in the context of HL relapse.

Published
2023
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28. Prospective Evaluation of Different Methods for Volumetric Analysis on [ 18 F]FDG PET/CT in Pediatric Hodgkin Lymphoma.

Author

Lopci E, Elia C, Catalfamo B, Burnelli R, De Re V, Mussolin L, Piccardo A, Cistaro A, Borsatti E, Zucchetta P, Bianchi M, Buffardi S, Farruggia P, Garaventa A, Sala A, Vinti L, Mauz-Koerholz C, and Mascarin M

Abstract

Rationale: Therapy response evaluation by 18F-fluorodeoxyglucose PET/CT (FDG PET) has become a powerful tool for the discrimination of responders from non-responders in pediatric Hodgkin lymphoma (HL). Recently, volumetric analyses have been regarded as a valuable tool for disease prognostication and biological characterization in cancer. Given the multitude of methods available for volumetric analysis in HL, the AIEOP Hodgkin Lymphoma Study Group has designed a prospective analysis of the Italian cohort enrolled in the EuroNet-PHL-C2 trial. Methods: Primarily, the study aimed to compare the different segmentation techniques used for volumetric assessment in HL patients at baseline (PET1) and during therapy: early (PET2) and late assessment (PET3). Overall, 50 patients and 150 scans were investigated for the current analysis. A dedicated software was used to semi-automatically delineate contours of the lesions by using different threshold methods. More specifically, four methods were applied: (1) fixed 41% threshold of the maximum standardized uptake value (SUVmax) within the respective lymphoma site (V41%), (2) fixed absolute SUV threshold of 2.5 (V2.5); (3) SUVmax(lesion)/SUVmean liver >1.5 (Vliver); (4) adaptive method (AM). All parameters obtained from the different methods were analyzed with respect to response. Results: Among the different methods investigated, the strongest correlation was observed between AM and Vliver (rho > 0.9; p < 0.001 for SUVmean, MTV and TLG at all scan timing), along with V2.5 and AM or Vliver (rho 0.98, p < 0.001 for TLG at baseline; rho > 0.9; p < 0.001 for SUVmean, MTV and TLG at PET2 and PET3, respectively). To determine the best segmentation method, we applied logistic regression and correlated different results with Deauville scores at late evaluation. Logistic regression demonstrated that MTV (metabolic tumor volume) and TLG (total lesion glycolysis) computation according to V2.5 and Vliver significantly correlated to response to treatment (p = 0.01 and 0.04 for MTV and 0.03 and 0.04 for TLG, respectively). SUVmean also resulted in significant correlation as absolute value or variation. Conclusions: The best correlation for volumetric analysis was documented for AM and Vliver, followed by V2.5. The volumetric analyses obtained from V2.5 and Vliver significantly correlated to response to therapy, proving to be preferred thresholds in our pediatric HL cohort.

Published
2022
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29. Classical Hodgkin's Lymphoma in the Era of Immune Checkpoint Inhibition.

Author

De Re V, Caggiari L, Repetto O, Mussolin L, and Mascarin M

Abstract

: The ligation of programmed cell death 1 (PD-1) with programmed cell death ligand PD-L activates the immune checkpoint leading to T-cell dysfunction, exhaustion, and tolerance, especially in Hodgkin lymphoma (HL) where the PD-L/ Janus kinase (Jak) signaling was frequently found altered. Anti-PD-1 or anti-PD-L1 monoclonal antibodies can reverse this immune checkpoint, releasing the brake on T-cell responses. The characterization of the mechanisms regulating both the expression of PD-1 and PD-L and their function(s) in HL is ongoing. We provide in this review the recent findings focused on this aim with special attention on the major research topics, such as adverse events and resistance to PD-1-PD-L1 inhibitor treatment, together with a part about angiogenesis, extracellular vesicles, and microbiome in HL pathogenesis., Competing Interests: The authors declare no conflicts of interest.

Published
2019
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30. Complete and Durable Response to Combined Chemo/Radiation Therapy in EGFR Wild-Type Lung Adenocarcinoma with Diffuse Brain Metastases.

Author

Santeufemia DA, Palmieri G, Cossu A, De Re V, Caggiari L, De Zorzi M, Casula M, Sini MC, Baldino G, Dedola MF, Corona G, and Miolo G

Abstract

Most non-small-cell lung cancer (NSCLC) patients are likely to develop brain metastases during the course of their illness. Currently, no consensus on NSCLC patients' treatment with brain metastasis has been established. Although whole brain radiotherapy prolongs the median survival time of approximately 4 months, a cisplatin-pemetrexed combination may also represent a potential option in the treatment of asymptomatic NSCLC patients with brain metastases. Herein, we report the case of a non-smoker male patient with multiple, large and diffuse brain metastases from an "epidermal growth factor receptor ( EGFR ) wild-type" lung adenocarcinoma who underwent an overly aggressive chemo/radiation therapy. This approach led to a complete and durable remission of the disease and to a long survival of up to 58 months from diagnosis of primary tumor. The uncommon course of this metastatic disease induced us to describe its oncological management and to investigate the molecular features of the tumor.

Published
2019
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