1. Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours
- Author
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Natalia Marek-Trzonkowska, Wojciech Biernat, Carla Montesano, Witold Rzyman, Jacek Kowalski, Tomasz Marjański, Mateusz Gliwiński, Rafal Dziadziuszko, Roberta Bernardini, Łukasz Arcimowicz, Małgorzata Kurkowiak, Elżbieta Chruściel, and Zuzanna Urban-Wójciuk
- Subjects
0301 basic medicine ,Cancer Research ,Adoptive cell transfer ,medicine.medical_treatment ,T cell ,Cell ,Review ,Settore MED/04 ,antigen- specific t cells ,lcsh:RC254-282 ,Cell therapy ,03 medical and health sciences ,0302 clinical medicine ,T cell-based therapy of solid tumours ,TCR therapy ,adoptive cell therapy of cancer ,antigen- specific T cells ,immunotherapy ,neoantigens ,medicine ,business.industry ,Immunotherapy ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Phenotype ,Chimeric antigen receptor ,Genetically modified organism ,tcr therapy ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,t cell-based therapy of solid tumours ,business - Abstract
In recent years, much research has been focused on the field of adoptive cell therapies (ACT) that use native or genetically modified T cells as therapeutic tools. Immunotherapy with T cells expressing chimeric antigen receptors (CARs) demonstrated great success in the treatment of haematologic malignancies, whereas adoptive transfer of autologous tumour infiltrating lymphocytes (TILs) proved to be highly effective in metastatic melanoma. These encouraging results initiated many studies where ACT was tested as a treatment for various solid tumours. In this review, we provide an overview of the challenges of T cell-based immunotherapies of solid tumours. We describe alternative approaches for choosing the most efficient T cells for cancer treatment in terms of their tumour-specificity and phenotype. Finally, we present strategies for improvement of anti-tumour potential of T cells, including combination therapies.
- Published
- 2020