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Your search keyword '"Giavarini, Flavio"' showing total 6 results
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6 results on '"Giavarini, Flavio"'

1. Ellagitannins from Castanea sativa Mill. Leaf Extracts Impair H. pylori Viability and Infection-Induced Inflammation in Human Gastric Epithelial Cells

Author

Piazza, Stefano, primary, Martinelli, Giulia, additional, Fumagalli, Marco, additional, Pozzoli, Carola, additional, Maranta, Nicole, additional, Giavarini, Flavio, additional, Colombo, Luca, additional, Nicotra, Giovanna, additional, Vicentini, Silvia Francesca, additional, Genova, Francesca, additional, De Fabiani, Emma, additional, Sangiovanni, Enrico, additional, and Dell’Agli, Mario, additional

Published
2023
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2. On the Redox-Activity and Health-Effects of Atmospheric Primary and Secondary Aerosol: Phenomenology

Author

Costabile, Francesca, primary, Decesari, Stefano, additional, Vecchi, Roberta, additional, Lucarelli, Franco, additional, Curci, Gabriele, additional, Massabò, Dario, additional, Rinaldi, Matteo, additional, Gualtieri, Maurizio, additional, Corsini, Emanuela, additional, Menegola, Elena, additional, Canepari, Silvia, additional, Massimi, Lorenzo, additional, Argentini, Stefania, additional, Busetto, Maurizio, additional, Di Iulio, Gianluca, additional, Di Liberto, Luca, additional, Paglione, Marco, additional, Petenko, Igor, additional, Russo, Mara, additional, Marinoni, Angela, additional, Casasanta, Gianpietro, additional, Valentini, Sara, additional, Bernardoni, Vera, additional, Crova, Federica, additional, Valli, Gianluigi, additional, Forello, Alice Corina, additional, Giardi, Fabio, additional, Nava, Silvia, additional, Pazzi, Giulia, additional, Prati, Paolo, additional, Vernocchi, Virginia, additional, La Torretta, Teresa, additional, Petralia, Ettore, additional, Stracquadanio, Milena, additional, Zanini, Gabriele, additional, Melzi, Gloria, additional, Nozza, Emma, additional, Iulini, Martina, additional, Caruso, Donatella, additional, Cioffi, Lucia, additional, Imperato, Gabriele, additional, Giavarini, Flavio, additional, Battistoni, Maria, additional, Di Renzo, Francesca, additional, Frezzini, Maria Agostina, additional, Perrino, Cinzia, additional, and Facchini, Maria Cristina, additional

Published
2022
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3. Ribes nigrum Leaf Extract Preferentially Inhibits IFN-γ-Mediated Inflammation in HaCaT Keratinocytes

Author

Magnavacca, Andrea, Piazza, Stefano, Cammisa, Anna, Fumagalli, Marco, Martinelli, Giulia, Giavarini, Flavio, Sangiovanni, Enrico, and Dell’Agli, Mario

Subjects
keratinocytes, Ribes nigrum, skin, QD241-441, blackcurrant leaves, inflammation, TSLP, Organic chemistry, IFN-γ, Article
Abstract

Ribes nigrum L. (blackcurrant) leaf extracts, due to high levels of flavonols and anthocyanins, have been shown to exhibit beneficial effects in inflammatory diseases. However, whereas their traditional use has been investigated and validated in several models of inflammation and oxidative stress, the possible impact on skin disorders is still largely unknown. The purpose of this work was to elucidate the effects of R. nigrum leaf extract (RNLE) on keratinocyte-derived inflammatory mediators, elicited by a Th1 or Th2 cytokine milieu. HaCaT cells were challenged with TNF-α, either alone or in combination with the costimulatory cytokines IFN-γ or IL-4, and the release of proinflammatory cytokines and mediators (IL-8, IL-6, s-ICAM-1, and TSLP) was evaluated. The results showed that RNLE preferentially interferes with IFN-γ signaling, demonstrating only negligible activity on TNF-α or IL-4. This effect was attributed to flavonols, which might also account for the ability of RNLE to impair TNF-α/IL-4-induced TSLP release in a cAMP-independent manner. These results suggest that RNLE could have an antiallergic effect mediated in keratinocytes via mechanisms beyond histamine involvement. In conclusion, the discovery of RNLE preferential activity against IFN-γ-mediated inflammation suggests potential selectivity against Th1 type response and the possible use in Th1 inflammatory diseases.

Published
2021

4. Gut Microbiota Functional Dysbiosis Relates to Individual Diet in Subclinical Carotid Atherosclerosis

Author

Baragetti, Andrea, primary, Severgnini, Marco, additional, Olmastroni, Elena, additional, Dioguardi, Carola Conca, additional, Mattavelli, Elisa, additional, Angius, Andrea, additional, Rotta, Luca, additional, Cibella, Javier, additional, Caredda, Giada, additional, Consolandi, Clarissa, additional, Grigore, Liliana, additional, Pellegatta, Fabio, additional, Giavarini, Flavio, additional, Caruso, Donatella, additional, Norata, Giuseppe Danilo, additional, Catapano, Alberico Luigi, additional, and Peano, Clelia, additional

Published
2021
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5. Schwann Cell Autocrine and Paracrine Regulatory Mechanisms, Mediated by Allopregnanolone and BDNF, Modulate PKCε in Peripheral Sensory Neurons

Author

Bonalume, Veronica, primary, Caffino, Lucia, additional, Castelnovo, Luca F., additional, Faroni, Alessandro, additional, Giavarini, Flavio, additional, Liu, Sheng, additional, Caruso, Donatella, additional, Schmelz, Martin, additional, Fumagalli, Fabio, additional, Carr, Richard W., additional, and Magnaghi, Valerio, additional

Published
2020
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