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Your search keyword '"Gijsen, Matthias"' showing total 13 results
Start Over Author "Gijsen, Matthias" Publisher mdpi ag
13 results on '"Gijsen, Matthias"'

1. Predicting Beta-Lactam Target Non-Attainment in ICU Patients at Treatment Initiation: Development and External Validation of Three Novel (Machine Learning) Models

Author

Wieringa, André, primary, Ewoldt, Tim M. J., additional, Gangapersad, Ravish N., additional, Gijsen, Matthias, additional, Parolya, Nestor, additional, Kats, Chantal J. A. R., additional, Spriet, Isabel, additional, Endeman, Henrik, additional, Haringman, Jasper J., additional, van Hest, Reinier M., additional, Koch, Birgit C. P., additional, and Abdulla, Alan, additional

Published
2023
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2. Isavuconazole Exposure in Critically Ill Patients Treated with Extracorporeal Membrane Oxygenation: Two Case Reports and a Narrative Literature Review

Author

Mertens, Beatrijs, primary, Elkayal, Omar, additional, Dreesen, Erwin, additional, Wauters, Joost, additional, Meersseman, Philippe, additional, Debaveye, Yves, additional, Degezelle, Karlien, additional, Vermeersch, Pieter, additional, Gijsen, Matthias, additional, and Spriet, Isabel, additional

Published
2023
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5. Systematic Comparison of Hospital-Wide Standard and Model-Based Therapeutic Drug Monitoring of Vancomycin in Adults

Author

Gastmans, Heleen, primary, Dreesen, Erwin, additional, Wicha, Sebastian G., additional, Dia, Nada, additional, Spreuwers, Ellen, additional, Dompas, Annabel, additional, Allegaert, Karel, additional, Desmet, Stefanie, additional, Lagrou, Katrien, additional, Peetermans, Willy E., additional, Debaveye, Yves, additional, Spriet, Isabel, additional, and Gijsen, Matthias, additional

Published
2022
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9. Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

Author

Van Daele, Ruth, primary, Wauters, Joost, additional, De Cock, Pieter, additional, Buyle, Franky, additional, Leys, John, additional, Van Brantegem, Pieter, additional, Gijsen, Matthias, additional, Annaert, Pieter, additional, Debaveye, Yves, additional, Lagrou, Katrien, additional, Peetermans, Willy E., additional, Brüggemann, Roger J., additional, and Spriet, Isabel, additional

Published
2021
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13. Meropenem Stability in Human Plasma at -20 °C: Detailed Assessment of Degradation.

Author

Gijsen M, Filtjens B, Annaert P, Armoudjian Y, Debaveye Y, Wauters J, Slaets P, and Spriet I

Abstract

There are concerns about the stability of meropenem in plasma samples, even when frozen at -20 °C. Previous smaller studies suggested significant degradation of meropenem at -20 °C after 3-20 days. However, in several recent clinical studies, meropenem plasma samples were still stored at -20 °C, or the storage temperature and/or time were not mentioned in the paper. The aim of this study was to describe and model meropenem degradation in human plasma at -20 °C over 1 year. Stability of meropenem in human plasma at -20 °C was investigated at seven concentrations (0.44, 4.38, 17.5, 35.1, 52.6, 70.1, and 87.6 mg/L) representative for the range of relevant concentrations encountered in clinical practice. For each concentration, samples were stored for 0, 7, 14, 21, 28, 42, 56, 70, 84, 112, 140, 168, 196, 224, 252, 280, 308, 336, and 364 days at -20 °C before being transferred to -80 °C until analysis. Degradation was modeled using polynomial regression analysis and artificial neural network (ANN). Meropenem showed significant degradation over time in human plasma when stored at -20 °C. Degradation was present over the whole concentration range and increased with higher concentrations until a concentration of 35.1 mg/L. Both models showed accurate prediction of meropenem degradation. In conclusion, this study provides detailed insights into the concentration-dependent degradation of meropenem in human plasma stored at -20 °C over 1 year. Meropenem in human plasma is shown to be stable at least up to approximately 80 days when stored at -20 °C. The polynomial model allows calculating original meropenem concentrations in samples stored for a known period of time at -20 °C.

Published
2021
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