1. The Epithelial–Mesenchymal Transition at the Crossroads between Metabolism and Tumor Progression
- Author
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Monica Fedele, Riccardo Sgarra, Sabrina Battista, Laura Cerchia, Guidalberto Manfioletti, Fedele, M., Sgarra, R., Battista, S., Cerchia, L., and Manfioletti, G.
- Subjects
Transcription Factor ,Drug Resistance ,tumor progression ,Review ,Breast cancer ,Neoplasms ,Tumor Microenvironment ,Molecular Targeted Therapy ,Biology (General) ,Cancer ,Epithelial–mesenchymal transition (EMT) ,Lung cancer ,Metabolic rewiring ,Metabolism ,Thyroid cancer ,Tumor progression ,Warburg effect ,Animals ,Biomarkers ,Biomarkers, Tumor ,Disease Management ,Disease Progression ,Disease Susceptibility ,Drug Resistance, Neoplasm ,Gene Expression Regulation, Neoplastic ,Humans ,Metabolic Networks and Pathways ,Neoplastic Stem Cells ,Organ Specificity ,Oxidative Stress ,RNA Interference ,RNA, Long Noncoding ,Signal Transduction ,Transcription Factors ,Energy Metabolism ,Epithelial-Mesenchymal Transition ,epithelial–mesenchymal transition (EMT) ,Spectroscopy ,Tumor ,General Medicine ,Computer Science Applications ,Chemistry ,Long Noncoding ,Human ,QH301-705.5 ,metabolic rewiring ,Catalysis ,Inorganic Chemistry ,cancer ,Physical and Theoretical Chemistry ,Molecular Biology ,QD1-999 ,Neoplastic ,Animal ,Organic Chemistry ,Metabolic Networks and Pathway ,Oxidative Stre ,Biomarker ,Gene Expression Regulation ,Neoplasm ,RNA ,Neoplastic Stem Cell ,metabolism - Abstract
The transition between epithelial and mesenchymal phenotype is emerging as a key determinant of tumor cell invasion and metastasis. It is a plastic process in which epithelial cells first acquire the ability to invade the extracellular matrix and migrate into the bloodstream via transdifferentiation into mesenchymal cells, a phenomenon known as epithelial–mesenchymal transition (EMT), and then reacquire the epithelial phenotype, the reverse process called mesenchymal–epithelial transition (MET), to colonize a new organ. During all metastatic stages, metabolic changes, which give cancer cells the ability to adapt to increased energy demand and to withstand a hostile new environment, are also important determinants of successful cancer progression. In this review, we describe the complex interaction between EMT and metabolism during tumor progression. First, we outline the main connections between the two processes, with particular emphasis on the role of cancer stem cells and LncRNAs. Then, we focus on some specific cancers, such as breast, lung, and thyroid cancer.
- Published
- 2022