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The arid area of Northwest China belongs to the rain-fed agricultural area of the Loess Plateau, and water resources have become one of the important factors limiting agricultural development in this area. This study employed the AquaCrop model to predict the yield advantages and environmental adaptability of maize in Dingxi City from 2016 to 2020 under two cultivation practices: ridge tillage (100% film coverage with double ridge-furrow planting) and flat planting (81.8% film coverage with wide-film planting). The numerical simulation of the tillage and fertilization process of the double-ridge seedbed was carried out by EDEM, and the key components were tested by the Box–Behnken center combination test design principle to obtain the optimal parameter combination. The results showed that ridge planting was more suitable for agricultural planting in rain-fed arid areas in Northwest China. The simulation analysis of ridging and fertilization showed that the forward speed of the combined machine was 0.50 m/s, the rotation speed of the trough wheel of the fertilizer discharger was 39 rmp, and the rotary tillage depth was 150 mm. The qualified rate of seedbed tillage was 93.6%, and the qualified rate of fertilization was 92.1%. The research shows that the whole-film double ridge-furrow sowing technology of maize is more suitable for the rain-fed agricultural area in the arid area of Northwest China. The simulation results of the ridging fertilization device are consistent with the field experiment results. The research results provide a certain technical reference for the optimization of the whole-film double ridge-furrow sowing technology.

Microplastics are omnipresent in aquatic environments and can act as vectors to carry other pollutants, modifying their pathway through the systems. In this study, the differences in the adsorption capacity and mechanism for Cr(VI) sorption with polyethylene (PE, a conventional microplastic) and polylactic acid (PLA, a biodegradable microplastic) were investigated via characterization of the MPs, the determination of kinetic behavior (pseudo-first- and second-order model, the Elovich model), and the degree of fit to Langmuir and Freundlich isothermal models; the adsorption behavior was also studied under different solution conditions. The results indicated that when the dose of MPs was 1 g/L, the adsorption capacity of Cr(VI) on MPs reached the highest value, the adsorption capacities were PLA(0.415 mg/g) > PE(0.345 mg/g). The adsorption of Cr(VI) on PE followed the Langmuir isotherm model, while PLA had a stronger fit with the Freundlich model. Sorption in both cases followed a pseudo-first-order kinetics model. The maximum adsorption capacity of Cr(VI) on PLA (0.54 mg/g) is higher than that on PE (0.38 mg/g). In addition, PLA could reach adsorption equilibrium in about 8 h and can adsorb 72.3% of the total Cr(VI) within 4 h, while PE required 16 h to reach equilibrium, suggesting that PLA adsorbs at a significantly faster rate than PE. Thus, biodegradable MPs like PLA may serve as a superior carrier for Cr(VI) in aquatic environments. When the pH increased from 2 to 6, the adsorption of Cr(VI) by PE and PLA decreased from 0.49 mg/g and 0.52 mg/g to 0.27 mg/g and 0.26 mg/g, respectively. When the concentration of sodium dodecyl sulfate in the Cr(VI) solution was increased from nil to 300 mg/L, the adsorption of Cr(VI) by PE and PLA increased by 3.66 and 3.05 times, respectively. In addition, a higher temperature and the presence of Cu2+ and photoaging promoted the adsorption of Cr(VI) by MPs, while higher salinity inhibited the adsorption. The desorption efficiencies of Cr(VI) on MPs were PLA(57.8%) > PE(46.4%). The characterization results further confirmed that the adsorption mechanism could be attributed to electrostatic attraction, hydrogen bonding, and surface complexation. In sum, PLA could potentially serve as better vectors for Cr(VI) than PE, but the risk associated with PLA might be higher than that with PE.

The inhibition of the immune response in the tumor microenvironment by therapy regimens can impede the eradication of tumors, potentially resulting in tumor metastasis. As a non-invasive therapeutic method, radiotherapy is utilized for tumor ablation. In this study, we aimed to improve the therapeutic impact of radiotherapy and trigger an immune response by formulating a benzothiazole sulfinate (BTS)-loaded fusion liposome (BFL) nanoplatform, which was then combined with radiotherapy for anti-cancer treatment. The platelet cell membrane, equipped with distinctive surface receptors, enables BFL to effectively target tumors while evading the immune system and adhering to tumor cells. This facilitates BFL’s engulfment by cancer cells, subsequently releasing BTS within them. Following the release, the BTS produces sulfur dioxide (SO2) for gas therapy, initiating the oxidation of intracellular glutathione (GSH). This process demonstrates efficacy in repairing damage post-radiotherapy, thereby achieving effective radiosensitization. It was revealed that an immune response was triggered following the enhanced radiosensitization facilitated by BFL. This approach facilitated the maturation of dendritic cell (DC) within lymph nodes, leading to an increase in the proportion of T cells in distant tumors. This resulted in significant eradication of primary tumors and inhibition of growth in distant tumors. In summary, the integration of personalized BFL with radiotherapy shows potential in enhancing both tumor immune response and the elimination of tumors, including metastasis.

Weeds compete with rice for sunlight and nutrients and are prone to harboring pathogens, leading to reduced rice yields. Addressing the issues of low weeding efficiency and weed mortality rates in existing inter-row weeding devices, the study proposes the design of a combination paddy field inter-row weeding wheel. The device’s operation process is theoretically analyzed based on the weed control requirements in the northeastern region of China, leading to the determination of specific structural parameters. This research conducted experiments on the mechanical properties of weed cutting to obtain geometric parameters for paddy field weeds. It was found that the range for the cutting gap of the dynamic–fixed blade is between 0.6 mm to 1.4 mm and the cutting angle is between 5° to 15°, resulting in the lowest peak cutting force for weeds. Using LS-DYNA R12.0.0 dynamic simulation software, a fluid–structure interaction (FSI) model of the weeding wheel–water–soil system was established. By employing the central composite experimental design principle and considering the soil stir rate and coupling stress as indicators, the optimal structural parameter combination for the device is obtained: a dynamic–fixed blade cutting gap of 1.4 mm, a cutting angle of 10.95°, and a dynamic blade install angle of −3.44°. Field experiments demonstrated that the device achieved an average weeding rate of 89.7% and an average seedling damage rate of 1.9%, indicating excellent performance. This study contributes to improving weed mortality rates and provides valuable guidance for inter-row mechanical weeding technology.

Perinatal and neonatal ischemic stroke is a significant cause of cognitive and behavioral impairments. Further research is needed to support models of neonatal ischemic stroke and advance our understanding of the mechanisms of infarction formation following such strokes. We used two different levels of photothrombotic stroke (PTS) models to assess stroke outcomes in neonatal mice. We measured brain damage, dynamic changes in glial cells, and neuronal expression at various time points within two weeks following ischemic injury. Our results from 2,3,5-Triphenyltetrazolium chloride (TTC) staining and immunofluorescence staining showed that in the severe group, a dense border of astrocytes and microglia was observed within 3 days post infarct. This ultimately resulted in the formation of a permanent cortical cavity, accompanied by neuronal loss in the surrounding tissues. In the mild group, a relatively sparse arrangement of glial borders was observed 7 days post infarct. This was accompanied by intact cortical tissue and the restoration of viability in the brain tissue beyond the glial boundary. Additionally, neonatal ischemic injury leads to the altered expression of key molecules such as Aldh1L1 and Olig2 in immature astrocytes. In conclusion, we demonstrated the dynamic changes in glial cells and neuronal expression following different degrees of ischemic injury in a mouse model of PTS. These findings provide new insights for studying the cellular and molecular mechanisms underlying neuroprotection and neural regeneration after neonatal ischemic injury.

Preharvest threshing is a harvesting method that focuses on collecting rice grains while leaving the rice straw unharvested. Investigating the interaction mechanism between the machine and rice during the operation process and its correlation with harvest losses is crucial for enhancing harvest quality. In this study, structural design and operational mechanism analysis of the combs was conducted through theoretical analysis. By extracting the relevant parameters of rice plants, a model of entire-plant rice during the harvesting period was established based on the discrete element method (DEM). Numerical simulation studies were conducted to clarify the interaction mechanism between the machinery and rice at different operating stages and under various operating parameters, as well as the impact of this interaction on operational quality. The simulation results revealed that various operating parameters had a significant impact on the sliding-cut effect between the combs and rice. A higher cylinder rotation speed enhanced the effect, whereas increased forward velocity hampered it. Additionally, the effect initially improved and then decreased with a higher threshing height. In the bench test, high-speed cameras were used to verify and further analyze the comb–rice interaction mechanism and explore the optimal working parameter combination. The results showed that at a rotation speed of 616 r/min, a forward velocity of 0.91 m/s, and a threshing height of 792 mm, the grain loss rate was 1.997%, and the impurity rate was 4.073%. The harvesting losses were effectively reduced, validating the effectiveness of the study on the interaction between the machinery and rice.

In order to solve the problems of poor hole-filling performance and the high seed-breakage rate of conventional rice bud seed precision hole direct seed-metering devices, a side-filled rice precision hole direct seed-metering device was developed, and the mechanism and force analyses for seeding operations were carried out. The key factors affecting seeding quality were determined: rotation speed, seeding angle and seeding height. By coupling the discrete element method (DEM) and multi-rigid body dynamics (MBD), the seed breakage rate and seeding performance at different rotation speeds were analyzed. Single-factor bench testing was used to analyze the effect of a duckbill unit on seeding performance under different factor levels. The three-factor and five-level quadratic regression orthogonal rotation center combination test methods were used to obtain the optimal working parameter combination. The test results showed that when the rotation speed was 47 r/min, the seeding angle was 19°, and the seeding height was 180 mm, the qualified index of seeding was 92.03%, the hole diameter qualified index was 91.62%, and the hole distance variation index was 7.17%. This study provides a reference for the research of mechanical rice sprouting seed-metering devices.

Successive years of straw mulching and returning straw to the fields in Northeast China have made strip-tillage necessary, and reasonable strip-tillage operations can create conditions for crop growth. However, there are limited research studies on the related equipment applicable to this area. In this paper, an automatic control strip-tillage machine is designed. According to the conventional planting pattern of maize in this region, the operative processes of the machine were determined, and a suitable strip seedbed structure could then be constructed under straw mulching conditions. The type of coulters and the structural parameters of the V-type soil-crushing wheel were determined through theoretical analysis. Based on the air spring and electric linear actuator, the plowing depth control system and the straw width control system were developed, respectively, so as to improve the stability of the machine operation. Field tests showed that when the forward speed, tillage depth, and theoretical width were 6–12 km/h, 6–12 cm, and 18–24 cm, respectively, the straw clearing rate, soil crushing rate, and tillage depth and breadth stability were higher than 90%, and the soil flatness was less than 2 cm. All the indexes satisfied the agronomic and technological requirements of corn cultivation. The results of this study can provide equipment and technical support for the further popularization of conservation tillage technology.

In order to accurately establish a discrete element model for the whole plant flexibility of upright rice during the harvesting period, several physical characteristics, such as geometric features, moisture content, and density, of the entire rice plant were measured, along with frictional properties, such as the static and rolling friction coefficients, and mechanical properties, including the elastic modulus and restitution coefficient. A flexible and upright discrete element model of the rice plant was established using the DEM method based on the Hertz–Mindlin (no slip) and Hertz–Mindlin with bonding mechanical models. The parameters were optimized through Plackett–Burman screening experiments, steepest ascent experiments, and Box–Behnken optimization experiments to accurately determine the discrete element model parameters of each component of the rice plant. The calibration process of the contact parameters between rice grains and steel was analyzed in detail as an example, resulting in a calibration error of 0.68% for the natural repose angle. Taking the calibration of the contact parameters between the main stem and steel as an example, a detailed analysis of the calibration process was conducted. The calibration resulted in a calibration error of 2.76% for the natural repose angle and 2.33% for deflection. This study lays the foundation for understanding the mechanical response of rice and machinery when they are coupled together. Additionally, it provides valuable references for establishing discrete element models of plant species other than rice.

The prediction of crop yield plays a crucial role in national economic development, encompassing grain storage, processing, and grain price trends. Employing multiple sensors to acquire remote sensing data and utilizing machine learning algorithms can enable accurate, fast, and nondestructive yield prediction for maize crops. However, current research heavily relies on single-type remote sensing data and traditional machine learning methods, resulting in the limited robustness of yield prediction models. To address these limitations, this study introduces a field-scale maize yield prediction model named the convolutional neural network–attention–long short-term memory network (CNN-attention-LSTM) model, which utilizes multimodal remote sensing data collected by multispectral and light detection and ranging (LIDAR) sensors mounted on unmanned aerial vehicles (UAVs). The model incorporates meteorological data throughout the crop reproductive stages and employs the normalized difference vegetation index (NDVI), normalized difference red edge (NDRE), soil-adjusted vegetation index (SAVI), and enhanced vegetation index (EVI) for the initial part of the vegetative stage (initial part of the V period), the later part of the vegetative stage (later part of the V period), the reproductive stage (R period), and the maturity stage (M period), along with LIDAR data for Point75–100 in the later part of the V period, Point80–100 in the R period, and Point50–100 in the M period, complemented by corresponding meteorological data as inputs. The resulting yield estimation demonstrates exceptional performance, with an R2 value of 0.78 and an rRMSE of 8.27%. These results surpass previous research and validate the effectiveness of multimodal data in enhancing yield prediction models. Furthermore, to assess the superiority of the proposed model, four machine learning algorithms—multiple linear regression (MLR), random forest regression (RF), support vector machine (SVM), and backpropagation (BP)—are compared to the CNN-attention-LSTM model through experimental analysis. The outcomes indicate that all alternative models exhibit inferior prediction accuracy compared to the CNN-attention-LSTM model. Across the test dataset within the study area, the R2 values for various nitrogen fertilizer levels consistently exceed 0.75, illustrating the robustness of the proposed model. This study introduces a novel approach for assessing maize crop yield and provides valuable insights for estimating the yield of other crops.

This study is aimed at the special working conditions of seeding on sloping land, combining advanced precision seeding technology and the structure of rotary hole filling corn precision metering device seed rowers at home and abroad, and studying soil entry characteristics, the characteristics of soil particles and the seed transport pattern in the puncture process, in order to improve the seed dispersal qualified index and reduce the coefficient of variation in the process of seeding. The simulation test of the cavity-tying device was carried out using the MBD–DEM coupling method, and it can be seen that the rocker bending angle is 120° when the force is the largest; at this time the rocker and the soil force is the largest, indicating the best effect on soil particle separation and the fastest movement speed. The single-factor test determined that the operating speed of the seed rower ranged from 0.8 to 1.2 m/s, the spring preload force of the seed rower ranged from 5.5 to 25 N, and the operating slope angle of the seed rower ranged from 8° to 16°. The optimal structure and parameter characteristics of the rotary hole filling corn precision metering device were determined with a multi-factor test, and it was proven that the rotary hole filling corn precision metering device has better performance and a higher seed rowing quality, with the qualified index reaching 96.2%. This study can provide a reference for the research of corn precision seeders, enrich the form of corn precision seeders, and effectively improve the level of corn mechanized seeding.

Ultraviolet (UV) irradiation causes 90% of photodamage to skin and long-term exposure to UV irradiation is the largest threat to skin health. To study the mechanism of UV-induced photodamage and the repair of sunburnt skin, the key problem to solve is how to non-destructively and continuously evaluate UV-induced photodamage to skin. In this study, a method to quantitatively analyze the structural and tissue optical parameters of artificial skin (AS) using optical coherence tomography (OCT) was proposed as a way to non-destructively and continuously evaluate the effect of photodamage. AS surface roughness was achieved based on the characteristic peaks of the intensity signal of the OCT images, and this was the basis for quantifying AS cuticle thickness using Dijkstra’s algorithm. Local texture features within the AS were obtained through the gray-level co-occurrence matrix method. A modified depth-resolved algorithm was used to quantify the 3D scattering coefficient distribution within AS based on a single-scattering model. A multiparameter assessment of AS photodamage was carried out, and the results were compared with the MTT experiment results and H&E staining. The results of the UV photodamage experiments showed that the cuticle of the photodamaged model was thicker (56.5%) and had greater surface roughness (14.4%) compared with the normal cultured AS. The angular second moment was greater and the correlation was smaller, which was in agreement with the results of the H&E staining microscopy. The angular second moment and correlation showed a good linear relationship with the UV irradiation dose, illustrating the potential of OCT in measuring internal structural damage. The tissue scattering coefficient of AS correlated well with the MTT results, which can be used to quantify the damage to the bioactivity. The experimental results also demonstrate the anti-photodamage efficacy of the vitamin C factor. Quantitative analysis of structural and tissue optical parameters of AS by OCT enables the non-destructive and continuous detection of AS photodamage in multiple dimensions.

In order to explore the influence of soil force on rotary soil-engaging components during their operation, a kinetic parameter measurement system of rotary soil-engaging components was developed via the sensor strain measurement technique. By taking a single-sided compacting ridge device as an example, the kinetic experiment was carried out on the operation parameters of the compacting device and obtained the variation law of the force of the soil on the pinnae. ADAMS software was used to simulate the operation of the compacting device under different experimental factors (soil moisture content, forward speed of the ridge device, and the rotation speed of the compacting device), and the test data were obtained; the experiment was carried out with the forward speed of the soil tanker and the rotation speed of the compacting device as the experimental factors, and the average of the force of soil on the pinnae and the firmness value of the ridge were the experimental indicators. The results showed that under a moisture content of 27%, the forward speed of the device was 0.8 km∙h−1, the maximum firmness of the ridge was 1233.21 kPa, the minimum firmness of the ridge was 953.85 kPa, and the coefficient of variation of the stability of the firmness value of the ridge was 8.04; the force of the pinnae on the soil increased with an increase in the forward speed of the soil tanker, and the variation range of the force was 2838.1–5695.2 N. It was verified that the design of this operation parameter measurement system for rotary soil-engaging components meets the practical requirements and also provides an important reference for the measurement of the relevant parameters of similar rotary soil-engaging components.

The deep application of liquid fertilizer in paddy fields is a fertilization technique that applies liquid fertilizer deep near the root system of paddy field crops, which can effectively improve the absorption rate of the crops and reduce the amount of fertilizer applied. In the cold regions of China, the soil return rate of the furrowing operation of the deep application of liquid fertilizer in paddy fields is low, which can easily cause the excessive liquid leakage of fertilizer and affect crop growth. Therefore, it is difficult to popularize in large areas. According to the characteristics of paddy soil in the cold regions of China and the operating requirements of a high backfill rate and low disturbance rate of the soil of the deep application of liquid fertilizer, this paper designed a bionic liquid fertilizer deep application furrow opener based on the claw-toe structure of the muskrat. In this study, an indoor soil bin test was conducted by constructing a deep application environment for the liquid fertilizer in paddy fields. The results of the soil bin test showed the effects of the key operating parameters of the bionic design of the liquid fertilizer deep application furrow opener, spraying pressure of the liquid fertilizer and operating speed on the furrowing resistance, soil disturbance rate and the leakage amount of liquid fertilizer. The bionic design of the liquid fertilizer deep application furrow opener has a low soil disturbance rate and leakage amount of fertilizer when the operating speed is 0.8 m s−1, and the spraying pressure is 0.2 MPa. This furrow opener significantly improves the operating performance of the deep application of liquid fertilizer in the cold regions of China and is suitable for the deep application of liquid fertilizer in the paddy fields of this region.

This paper aims to solve the problem of high reseeding rates and mis-seeding rates in the rice multi-grain hole direct seeding process. A multi grain cluster air suction type rice hill direct seed metering device was developed, and its seeding mechanism was analyzed. Based on CFD-DEM coupling simulation and bench tests, this study explored and optimized the performance of the seed metering device, and carried out the seeding adaptability test. The simulation results were as follows: when the negative pressure was −5 kPa, the static pressure, dynamic pressure and velocity of the flow field reached the maximum. When the negative pressure was −4 kPa, the qualification index was 89.62%, the reseeding index was 4.36%, and the mis-seeding index was 6.02%. The results of the orthogonal rotation combination test of three factors and five levels showed that when the rotation speed, negative pressure and the length of stirring brush were 20.70 rpm, −4.0 kPa and 10.50 mm respectively, the seed metering performance was the best, the qualification index was 90.85%, the reseeding index was 4.41% and the mis-seeding index was 4.74%. The seed metering device had strong adaptability to the sowing of different rice varieties, and met the agronomic requirements of direct seeding and seeding in rice holes.

Liquid fertilizer has many advantages, such as low production cost and little environmental pollution. Liquid fertilizer open furrow strip application method is widely used in fertilizer application operation. The widely used core-share furrow opener has a high operational resistance, disturbing the soil, hurting the crop roots, causing the liquid fertilizer to volatilize and deteriorating the fertilization effect. In this study, based on the streamline curve of the sturgeon body, we designed several bionic sturgeon liquid fertilizer deep application openers by combining bionics and analyzed the effects of several openers under different operating speeds on open furrow resistances and soil disturbance based on the discrete element method. The mechanism of open furrow resistances reduction and efficient soil backfill of the bionic structure were verified by indoor soil bin tests. The test results show that, compared with the core-share type furrow opener, both open furrow resistances and soil disturbance of the bionic sturgeon liquid fertilizer deep application opener are smaller. This study provides theoretical and practical references for the design of liquid fertilizer deep application openers.

To study the accumulation characteristics of rice seeds with different moisture content, an accurate model of rice seeds was established by 3D scanning technology. The accumulation state of rice seeds by the “point source” accumulation method was analyzed by proportioning and measuring the simulation parameters with different moisture content. The accumulation process was simulated at 10.23%, 14.09%, 17.85%, 21.77%, 26.41% and 29.22% moisture content, respectively. The velocity and force state of the seeds were visually analyzed by using the accumulation process with a moisture content of 29.22%. The accumulation process was divided into four stages according to the velocity characteristics of the seeds. The average force and kinetic energy of the rice seeds outside the cylinder were obtained, and the average force of the rice seeds outside the cylinder was proved to be the direct cause of the velocity change during the accumulation process. The mechanical characteristics of rice seeds in the quasi-static accumulation stage were partitioned and systematically analyzed. The force distribution of the “central depression” structure of rice seeds with a moisture content of 10.23%, 14.09% and 17.85% on the horizontal surface appeared. The higher the moisture content of rice seeds, the more likely the typical “circular” force structure appeared, and the more uniformly the force on the horizontal surface was distributed in the circumference direction.

To solve the problems of poor quality mechanical weeding and no obvious plowing effect in complex paddy field environments, the burying weeding operation mode was proposed. The height and force acting on the weeds were the main factors that altered the effectiveness of burying. The structure of the rake teeth weeding wheel was designed and matched with appropriate power, and the rake teeth weeding device was optimized. To verify the rationality of the designed device, the forward speed of the machine, rotating speed of the weeding wheels and weeding depth were selected as the experimental factors, and the inter row weeding rate was selected as the experimental index. A quadratic orthogonal rotation combination experiment with three factors and five levels was designed and optimized. The results showed that when the forward speed was 0.64 m/s, the rotational speed of the weeding wheel was 140 r/min, the weeding depth was 56.8 mm, the inter row weeding rate predicted by the model was 88.43%, and the inter row weeding rate was determined by a confirmatory experiment to be 87.06%, which met the weeding requirements for modern agronomy. To intuitively analyze how the soil was disturbed by the weeding wheel, the explicit dynamic analysis software LS-DYNA was used to build a fluid–solid coupling simulation model of the weeding wheel and water soil. The soil density and coupling stress were used to analyze the plowing state of paddy soil when the weeding wheel was operated. This study provides references for the design and development of paddy field weeding components and for mechanical and soil coupling simulation in paddy fields.

The fluctuation effect of corn grain often occurs during the unloading stage. To accurately explore the periodic pulsation characteristics of corn grain during the unloading stage, a discrete model of corn grain was established, and the effectiveness of the discrete element method in simulating the corn grain unloading stage was verified by a 3D laser scanner and the “spherical particle filling method”. The grain cylinder was divided into six areas, and the periodic pulsation characteristics at different heights were explored through simulation tests. The results showed that the faster the average speed of corn grain changes in unit time, the more significant the periodic pulsation characteristics were as the height of grain unloading increased. The corn grain pulsateon in the grain cylinder exhibited gradual upward transmission and gradual amplification in the process of transmission. The average velocity decreased with increasing height. The direct cause of pulsation was the variation in the average stress between grain layers. Simulation analysis of grain unloading for different half cone angles of the grain cylinder was carried out. The change in corn grain average velocity over time in the area below 20 mm of the upper free surface was extracted. The results showed that the speed of the top corn grain increased with increasing the half cone angle, and the periodic pulsation phenomenon became more obvious with increasing the half cone angle at half cone angles of 30–65°. A half cone angle of 65–70° marked the critical state of corn grain flow changing from funnel flow to overall flow in the grain cylinder. This study provides a method for studying the periodic pulsation characteristics of different crops during the grain unloading stage and provides a technical reference for the safe design of grain unloading equipment.

Based on the data of 82 meteorological stations and six representative hydrological stations in four provinces in Southwest China (Guizhou, Sichuan, Yunnan, Chongqing), this paper uses standardized precipitation evapotranspiration index (SPEI) and standardized runoff index (SRI) to analyze the spatial and temporal evolution characteristics of drought in the study area from 1968 to 2018. Combined with the Southwest monsoon index and historical drought data, the correlation of drought and the applicability of different drought indices were verified. The results show that: (1) SPEI-12 in Southwest China shows a downward trend from 1968 to 2018, with a linear trend rate of −0.074/10a, and SPEI-3 has a downward trend in four seasons, the maximum linear trend rate being −0.106/10a in autumn;(2) The change in SRI-12 and SRI-24 value directly reflected the decrease in SRI value, indicating that drought events are increasing in recent times, especially in the 21st century (3). Severe drought occurred in the south of Southwest China, as indicated by the increase of drought frequency in this area. The main reason for the variations in the frequency distribution of drought in Southwest China is the combined effect of the change of precipitation and evapotranspiration. (4) The correlation between hydrological drought index and disaster areas is stronger than the correlation between meteorological drought and disaster areas.

It is difficult to determine the coefficient of restitution accurately due to the small size, light weight, and complex influencing factors of rice grain. In the study, the experimental principle of restitution coefficient was described by the impact method, and the restitution coefficients of four typical rice varieties in Northeast China were measured. According to the orthogonal experiment, the primary and secondary factors affecting the restitution coefficient of rice grain were collision material, spring compression (initial collision velocity), moisture content, and rice variety. A single factor test was carried out for the significant factors, and the results showed that: The restitution coefficient of rice grain to a Q235 steel plate, plexiglass plate, seed plate, and rubber plate decreased in turn, and the restitution coefficient gradually decreased with the increase of spring compression (initial collision velocity), and with the increase of water content. The restitution coefficient was obtained by a bench test and simulation test, and the results were 0.429 and 0.423, respectively. The reason for the error was discussed and analyzed, which effectively verified the validity of the measurement of the restitution coefficient of small grain size. This study provides a method for the determination of the restitution coefficient of small grain, and provides a reference for the optimization design of threshing and a cleaning device of the combine harvester and high-speed precision seeder.

The longitudinal axial flow threshing cylinder of the full feeding rice combine harvester is widely used in China and works with violent vibration. To explore the source of the excitation affecting the vibration and to reduce the vibration, a finite element modal analysis and multipoint input and multipoint output (MIMO) modal test were performed to solve the natural vibration characteristics. By analyzing the excitation frequency, we concluded that the main reason for the resonance was the coupling between the rotation frequency of the threshing cylinder and the first natural frequency. To avoid the influence of resonance and realize a lightweight design, we proposed a combination of size optimization and topology optimization. The second rotation orthogonal combination test was designed to analyze the first natural frequency, maximum stress, and maximum deformation of the threshing cylinder, and the threshing cylinder was reconstructed as a central symmetrical structure to balance the rotational inertia force. The field experiment results showed that the amplitudes of the optimized threshing cylinder were significantly lower than those of the original threshing cylinder. This study provides ideas for solving the vibration characteristics of rotating parts and provides an important reference for the design of vibration reduction and weight reduction of key parts in the field of agricultural machinery.

Six new C-20 and one new C-19 quassinoids, named perforalactones F-L (1–7), were isolated from twigs of Harrisonia perforata. Spectroscopic and X-ray crystallographic experiments were conducted to identify their structures. Through oxidative degradation of perforalactone B to perforaqussin A, the biogenetic process from C-25 quassinoid to C-20 via Baeyer–Villiger oxidation was proposed. Furthermore, the study evaluated the anti-Parkinson’s disease potential of these C-20 quassinoids for the first time on 6-OHDA-induced PC12 cells and a Drosophila Parkinson’s disease model of PINK1B9. Perforalactones G and I (2 and 4) showed a 10–15% increase in cell viability of the model cells at 50 μM, while compounds 2 and 4 (100 μM) significantly improved the climbing ability of PINK1B9 flies and increased the dopamine level in the brains and ATP content in the thoraces of the flies.

Indium is considered a candidate low-temperature solder because of its low melting temperature and excellent mechanical properties. However, the solid-state microstructure evolution of In with different substrates has rarely been studied due to the softness of In. To overcome this difficulty, cryogenic broad Ar+ beam ion polishing was used to produce an artifact-free Cu/In interface for observation. In this study, we accomplished phase identification and microstructure investigation at the Cu/In interface after long-term thermal aging. CuIn2 was observed to grow at the Cu/In interface and proved to be a stable phase in the Cu–In binary system. The peritectoid temperature of the Cu11In9 + In → CuIn2 reaction was confirmed to be between 100 and 120 °C. In addition, the growth rate of CuIn2 was discovered to be dominated by the curvature of the reactant Cu11In9/In phase and the temperature difference with the peritectoid temperature. Finally, a comprehensive microstructural evolution mechanism of the Cu/In solid-state interfacial reaction was proposed.

In alcohol-associated liver disease (ALD), hepatic reductions in vitamin A and perturbations in vitamin A metabolism are common. However, the roles that the vitamin A receptors, termed retinoic acid receptors (RARs), may have in preventing the pathophysiology of ALD remains unclear. Our prior data indicate that a RARβ agonist limits the pathology of alcohol-related liver disease. Thus, we generated liver-specific AlbCre–RARβ knockout (BKO) mice and compared them to wild type (WT) mice in an early ALD model. Both strains showed similar blood ethanol concentrations and ETOH-metabolizing enzymes. However, the livers of pair-fed-BKO and ETOH-BKO mice developed higher levels of steatosis and triglycerides than pair-fed-WT and ETOH-WT mice. The increased hepatic steatosis observed in the pair-fed-BKO and ETOH-BKO mice was associated with higher lipid synthesis/trafficking transcripts and lower beta-oxidation transcripts. ETOH-BKO mice also exhibited a higher integrated stress response (ISR) signature, including higher transcript and protein levels of ATF4 and its target, 4-EBP1. In human hepatocytes (HepG2) that lack RARβ (RARβ-KO), ETOH treatments resulted in greater reactive oxygen species compared to their parental cells. Notably, even without ETOH, ATF4 and 4-EBP1 protein levels were higher in the RARβ-KO cells than in their parental cells. These 4-EBP1 increases were greatly attenuated in cultured ATF4-deficient and RARβ/ATF4-deficient HepG2, suggesting that RARβ is a crucial negative regulator of 4-EBP1 through ATF4 in cultured hepatocytes. Here, we identify RARβ as a negative regulator of lipid metabolism and cellular stress in ALD.

Eutectic In-48Sn was considered a promising candidate for low-temperature solder due to its low melting point and excellent mechanical properties. Both Cu2(In,Sn) and Cu(In,Sn)2 formation were observed at the In-48Sn/Cu interface after 160 °C soldering. However, traditional mechanical polishing produces many defects at the In-48Sn/Cu interface, which may affect the accuracy of interfacial reaction investigations. In this study, cryogenic broad Ar+ beam ion milling was used to investigate the interfacial reaction between In-48Sn and Cu during soldering. The phase Cu6(Sn,In)5 was confirmed as the only intermetallic compound formed during 150 °C soldering, while Cu(In,Sn)2 formation was proven to be caused by room-temperature aging after soldering. Both the Cu6(Sn,In)5 and Cu(In,Sn)2 phases were confirmed by EPMA quantitative analysis and TEM selected area electron diffraction. The microstructure evolution and growth mechanism of Cu6(Sn,In)5 during soldering were proposed. In addition, the Young’s modulus and hardness of Cu6(Sn,In)5 were determined to be 119.04 ± 3.94 GPa and 6.28 ± 0.13 GPa, respectively, suggesting that the doping of In in Cu6(Sn,In)5 has almost no effect on Young’s modulus and hardness.

Global warming, climate change, and ever-increasing energy demand are among the pressing challenges currently facing humanity. Particularly, indoor air conditioning, a major source of energy consumption, requires immediate improvement to prevent energy crises. In this study, various airfoil profiles were applied to create a window-type convection device that entrains air to improve convection between indoor and outdoor airflows and adjust the indoor temperature. How the geometric structure of the convection device affects its air entrainment performance was investigated on the basis of various airfoil profiles and outlet slit sizes of the airflow multiplier. The airfoil profiles were designed according to the 4-digit series developed by the National Advisory Committee for Aeronautics. The results revealed that airfoil thickness, airfoil camber, and air outlet slit size affected the mass flow rate of the convection device. Overall, the mass flow rate at the outlet of the convection device was more than 10 times greater than at the inlet, demonstrating the potential of the device to improve air convection. To validate these simulated results, the wind-deflector plate was processed using the NACA4424 airfoil with a 1.2 mm slit, and various operating voltages were applied to the convection device to measure the resulting wind speeds and calculate the corresponding mass flow rates. The experimental and simulated results were similar, with a mean error of