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Start Over Author "Hariharan. Sivaramakrishnan" Publisher mdpi ag
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1. Detection, Isolation and Characterization of Principal Synthetic Route Indicative Impurities in Verapamil Hydrochloride

Author

Viswanathan Srinivasan, Hariharan Sivaramakrishnan, and B. Karthikeyan

Subjects
Chromatography, Preparative hplc, Chemistry, Pharmaceutical Science, MS, Mass spectrometry, Verapamil hydrochloride, High-performance liquid chromatography, Bulk drug, NMR, Verapamil Hydrochloride, Impurity Analysis, Impurity, HPLC, Spectral data, Spectroscopy, Research Article
Abstract

Two unknown impurities were detected in verapamil hydrochloride bulk drug using isocratic reversed-phase high performance liquid chromatography (HPLC). These impurities were isolated by preparative HPLC. Spectral data for the isolated impurities were collected. Based on the spectral data derived from two-dimensional nuclear magnetic resonance (2D-NMR) spectroscopy and mass spectrometry (MS), impurity-1 and impurity-2 were characterized as 2-(3,4-dimethoxyphenyl)-3-methylbut-2-enenitrile and 2-(3,4-dimethoxyphenyl)-2-isopropyl-3-methylbutanenitrile, respectively.

Published
2011
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