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Hessenberg differential algebraic equations (Hessenberg-DAEs) with a high index play a critical role in the modeling of mechanical systems and multibody dynamics. Motivated by the widely used Lie-group differential algebraic equation (LGDAE) method, which handles index-2 systems, we first propose a modified extended Lie-group differential algebraic equation (MELGDAE) method for solving index-3 Hessenberg-DAEs and then provide a theoretical analysis to deepen the foundation of the MELGDAE method. Moreover, the performance of the MELGDAE method is compared with the standard methods RADAU and MEBDF on index-2 and -3 DAE systems, and it is demonstrated that the MELGDAE integrator exhibits a competitive performance in terms of high accuracy and the preservation of algebraic constraints. In particular, all differential variables in index-3 Hessenberg-DAEs achieve second-order convergence using the MELGDAE method, which suggests the potential for extension to Hessenberg-DAEs with an index of 4 or higher.

The k-means problem has been paid much attention for many applications. In this paper, we define the uncertain constrained k-means problem and propose a (1+ϵ)-approximate algorithm for the problem. First, a general mathematical model of the uncertain constrained k-means problem is proposed. Second, the random sampling properties of the uncertain constrained k-means problem are studied. This paper mainly studies the gap between the center of random sampling and the real center, which should be controlled within a given range with a large probability, so as to obtain the important sampling properties to solve this kind of problem. Finally, using mathematical induction, we assume that the first j−1 cluster centers are obtained, so we only need to solve the j-th center. The algorithm has the elapsed time O((1891ekϵ2)8k/ϵnd), and outputs a collection of size O((1891ekϵ2)8k/ϵn) of candidate sets including approximation centers.

In order to realize single fault detection (SFD) from the multi-fault coupling bearing data and further research on the multi-fault situation of bearings, this paper proposes a method based on features self-extraction of a Sparse Auto-Encoder (SAE) and results fusion of improved Dempster−Shafer evidence theory (D−S). Multi-fault signal compression features of bearings were extracted by SAE on multiple vibration sensors’ data. Data sets were constructed by the extracted compression features to train the Support Vector Machine (SVM) according to the rule of single fault detection (R-SFD) this paper proposed. Fault detection results were obtained by the improved D−S evidence theory, which was implemented via correcting the 0 factor in the Basic Probability Assignment (BPA) and modifying the evidence weight by Pearson Correlation Coefficient (PCC). Extensive evaluations of the proposed method on the experiment platform datasets showed that the proposed method could realize single fault detection from multi-fault bearings. Fault detection accuracy increases as the output feature dimension of SAE increases; when the feature dimension reached 200, the average detection accuracy of the three sensors for bearing inner, outer, and ball faults achieved 87.36%, 87.86% and 84.46%, respectively. The three types’ fault detection accuracy—reached to 99.12%, 99.33% and 98.46% by the improved Dempster−Shafer evidence theory (IDS) to fuse the sensors’ results—is respectively 0.38%, 2.06% and 0.76% higher than the traditional D−S evidence theory. That indicated the effectiveness of improving the D−S evidence theory by evidence weight calculation of PCC.

Effective feature selection can help improve the classification performance in bearing fault diagnosis. This paper proposes a novel feature selection method based on bearing fault diagnosis called Feature-to-Feature and Feature-to-Category- Maximum Information Coefficient (FF-FC-MIC), which considers the relevance among features and relevance between features and fault categories by exploiting the nonlinearity capturing capability of maximum information coefficient. In this method, a weak correlation feature subset obtained by a Feature-to-Feature-Maximum Information Coefficient (FF-MIC) matrix and a strong correlation feature subset obtained by a Feature-to-Category-Maximum Information Coefficient (FC-MIC) matrix are merged into a final diagnostic feature set by an intersection operation. To evaluate the proposed FF-FC-MIC method, vibration data collected from two bearing fault experiment platforms (CWRU dataset and CUT-2 dataset) were employed. Experimental results showed that accuracy of FF-FC-MIC can achieve 97.50%, and 98.75% on the CWRU dataset at the motor speeds of 1750 rpm, and 1772 rpm, respectively, and reach 91.75%, 94.69%, and 99.07% on CUT-2 dataset at the motor speeds of 2000 rpm, 2500 rpm, 3000 rpm, respectively. A significant improvement of FF-FC-MIC has been confirmed, since the p-values between FF-FC-MIC and the other methods are 1.166 × 10 − 3 , 2.509 × 10 − 5 , and 3.576 × 10 − 2 , respectively. Through comparison with other methods, FF-FC-MIC not only exceeds each of the baseline feature selection method in diagnosis accuracy, but also reduces the number of features.

Intelligent machine health monitoring and fault diagnosis are becoming increasingly important for modern manufacturing industries. Current fault diagnosis approaches mostly depend on expert-designed features for building prediction models. In this paper, we proposed IDSCNN, a novel bearing fault diagnosis algorithm based on ensemble deep convolutional neural networks and an improved Dempster–Shafer theory based evidence fusion. The convolutional neural networks take the root mean square (RMS) maps from the FFT (Fast Fourier Transformation) features of the vibration signals from two sensors as inputs. The improved D-S evidence theory is implemented via distance matrix from evidences and modified Gini Index. Extensive evaluations of the IDSCNN on the Case Western Reserve Dataset showed that our IDSCNN algorithm can achieve better fault diagnosis performance than existing machine learning methods by fusing complementary or conflicting evidences from different models and sensors and adapting to different load conditions.

Harringtonolide (HO), a natural product isolated from Cephalotaxus harringtonia, exhibits potent antiproliferative activity. However, little information has been reported on the systematic structure−activity relationship (SAR) of HO derivatives. Modifications on tropone, lactone, and allyl positions of HO (1) were carried out to provide 17 derivatives (2–13, 11a–11f). The in vitro antiproliferative activity against four cancer cell lines (HCT-116, A375, A549, and Huh-7) and one normal cell line (L-02) was tested. Amongst these novel derivatives, compound 6 exhibited comparable cell growth inhibitory activity to HO and displayed better selectivity index (SI = 56.5) between Huh-7 and L-02 cells. The SAR results revealed that the tropone and lactone moieties are essential for the cytotoxic activities, which provided useful suggestions for further structural optimization of HO.