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2 results on '"Juan José Rodríguez-Arias"'

1. Acute and Chronic Effects of COVID-19 on the Cardiovascular System

Author

Victor Arévalos, Luis Ortega-Paz, Juan José Rodríguez-Arias, Margarita Calvo López, Leticia Castrillo-Golvano, Anthony Salazar-Rodríguez, Marta Sabaté-Tormos, Francesco Spione, Manel Sabaté, and Salvatore Brugaletta

Subjects
coronavirus disease 2019, SARS-CoV-2, myocardial injury, myocarditis, myocardial infarction, pulmonary embolism, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

COVID-19 has shown significant morbidity with the involvement of multiple systems, including the cardiovascular system. Cardiovascular manifestations in the acute phase can include myocardial injury itself, myocardial infarction, venous thromboembolic events, myocarditis, Takotsubo syndrome, and different arrhythmic events. Myocardial injury defined by the rise of cardiac biomarkers in blood has been found in multiple studies with a prevalence of about 20%. Its presence is related to worse clinical outcomes and in-hospital mortality. The mechanisms of myocardial injury have been the subject of intense research but still need to be clarified. The characterization of the cardiac affectation with echocardiography and cardiac magnetic resonance has found mixed results in different studies, with a striking incidence of imaging criteria for myocarditis. Regarding post-acute and chronic follow-up results, the persistence of symptoms and imaging changes in recovered COVID-19 patients has raised concerns about the duration and the possible significance of these findings. Even though the knowledge about this disease has increased incredibly in the last year, many aspects are still unclear and warrant further research.

Published
2021
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2. Alcohol Septal Ablation: An Option on the Rise in Hypertrophic Obstructive Cardiomyopathy

Author

Juan José Rodríguez-Arias, Mónica Masotti, Xavier Freixa, Ander Regueiro, Salvatore Brugaletta, Manel Sabaté, Antonio Micari, Victor Arévalos, and Francesco Costa

Subjects
medicine.medical_specialty, Alcohol septal ablation, alcohol septal ablation, Infarction, Review, 030204 cardiovascular system & hematology, Sudden cardiac death, 03 medical and health sciences, Basal (phylogenetics), 0302 clinical medicine, Internal medicine, hypertrophic obstructive cardiomyopathy, medicine, cardiovascular diseases, 030212 general & internal medicine, Interventricular septum, business.industry, Hypertrophic cardiomyopathy, General Medicine, medicine.disease, Septal myectomy, medicine.anatomical_structure, Cardiology, Medicine, business, Complication, septal myectomy
Abstract

Hypertrophic cardiomyopathy (HCM) can cause symptoms due to the obstruction of the left ventricle outflow tract (LVOT). Although pharmacological therapy is the first step for treating this condition, many patients do not fully respond to the treatment, and an invasive approach is required to manage symptoms. Septal reduction therapies include septal myectomy (SM) and alcohol septal ablation (ASA). ASA consists of a selective infusion of high-grade alcohol into a septal branch supplying the basal interventricular septum to create an iatrogenic infarction with the aim of reducing LVOT obstruction. Currently, SM and ASA have the same level of indication; however, ASA is normally reserved for patients of advanced age, with comorbidities or when the surgical approach is not feasible. Recent data suggests that there are no differences in short- and long-term all-cause mortality, cardiovascular mortality and sudden cardiac death between ASA and SM. Despite the greater experience and refinement of the technique gained in recent years, the most common complication continues to be complete atrio-ventricular block, requiring a permanent pacemaker. Septal reduction therapies should be performed in experienced centres with comprehensive programs.

Published
2021

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