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2 results on '"Juhua Feng"'

1. DABCO-Catalyzed Mono-/Diallylation of N-Unsubstituted Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipoles with Morita-Baylis-Hillman Carbonates

Author

Qiumi Wang, Sicheng Li, Guosheng Yang, Xinyu Zou, Xi Yin, Juhua Feng, Huabao Chen, Chunping Yang, Li Zhang, Cuifen Lu, and Guizhou Yue

Subjects
azomethine imine, allylation, dipole, MBH carbonate, cycloaddition, Organic chemistry, QD241-441
Abstract

Allylation of N-unsubstituted isatin N,N′-cyclic azomethine imines with Morita-Baylis-Hillman carbonates in the presence of 1–10 mol% DABCO in DCM at room temperature, rapidly gave N-allylated and N, β-diallylated isatin N,N′-cyclic azomethine imine 1,3-dipoles in moderate to high yields. The reaction features mild reaction conditions, easily practical operation, and short reaction times in most cases. Furthermore, the alkylated products were transformed into novel bicyclic spiropyrrolidine oxoindole derivatives through the [3+2] or [3+3]-cycloaddition with maleimides or Knoevenagel adducts.

Published
2023
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2. Syntheses of 3,3-Disubstituted Dihydrobenzofurans, Indolines, Indolinones and Isochromanes by Palladium-Catalyzed Tandem Reaction Using Pd(PPh3)2Cl2/(±)-BINAP as a Catalytic System

Author

Xu Song, Li Zhang, Dan Jiang, Xiaoxia Liang, Juhua Feng, Huabao Chen, Xianxiang Wang, Sicheng Li, Guizhou Yue, Chunping Yang, Cuifen Lu, Zhongqiong Yin, and Gang Ding

Subjects
dihydrobenzofurans, Tandem, indolines, indolinones, chemistry.chemical_element, Carbon-13 NMR, lcsh:Chemical technology, Sulfur, Medicinal chemistry, Catalysis, lcsh:Chemistry, chemistry.chemical_compound, lcsh:QD1-999, Cascade reaction, chemistry, Reagent, isochromanes, lcsh:TP1-1185, tandem reaction, Physical and Theoretical Chemistry, Palladium, BINAP
Abstract

A general procedure for the tandem arylation reaction of arylbromide with heteroaryl compounds was developed by using Pd(PPh3)2Cl2/(&plusmn, )-BINAP (1,1&prime, Binaphthalene-2,2&prime, diylbis (diphenylphosphane)) as catalytic system. Both sulphur- and oxygen-containing heterocycles were also employed as an efficient reagent for arylation, which gave moderate to excellent yields with moderate to good regioselectivities (5:1 to &gt, 20:1 ir (isomer ratio)). Except for dihydrobenzofurans, indolines and indolinones, this type of tandem reaction was also expanded to synthesize isochromanes. The synthesized new compounds were well characterized through different spectroscopic techniques, such as 1H and 13C NMR (nuclear magnetic resonance), and mass spectral analysis.

Published
2020
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