1. The Oral Administration of Sanguisorba officinalis Extract Improves Physical Performance through LDHA Modulation
- Author
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Jung Sook Jin, MinJeong Kim, Syng-Ook Lee, Sung-Jin Bae, Ki-Tae Ha, Hee-Jin Choi, Dongryeol Ryu, and Jung Ho Han
- Subjects
Male ,Phytochemicals ,Administration, Oral ,Pharmaceutical Science ,AMP-Activated Protein Kinases ,Pharmacology ,Sanguisorba ,Analytical Chemistry ,Sanguisorba officinalis L ,Mice ,0302 clinical medicine ,Sanguisorba officinalis ,Drug Discovery ,Glycolysis ,0303 health sciences ,education.field_of_study ,biology ,Chemistry ,glycolysis ,Physical Functional Performance ,Medicine, Korean Traditional ,Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ,Chemistry (miscellaneous) ,030220 oncology & carcinogenesis ,herbal medicine ,Officinalis ,Molecular Medicine ,medicine.symptom ,Myoblasts, Skeletal ,Lactate dehydrogenase A ,Alpha (ethology) ,Inflammation ,Article ,LDHA ,Cell Line ,lcsh:QD241-441 ,03 medical and health sciences ,lcsh:Organic chemistry ,medicine ,Animals ,Lactic Acid ,Physical and Theoretical Chemistry ,education ,030304 developmental biology ,Plants, Medicinal ,Muscle fatigue ,Plant Extracts ,Organic Chemistry ,physical performance ,biology.organism_classification ,Enzyme assay ,Mice, Inbred C57BL ,Exercise Test ,Physical Endurance ,biology.protein ,Lactate Dehydrogenase 5 ,Phytotherapy - Abstract
Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of Sanguisorba officinalis L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the S. officinalis-administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1α) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, S. officinalis might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.
- Published
- 2021
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