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Background: Cyberbullying and nighttime phone use are independently detrimental to sleep and psychological wellbeing, but whether in combination they might be more disruptive remains unknown. Methods: Students aged 7–19 years (N = 53,734) completed a survey measuring sleep duration, nighttime phone use, cyberbullying, and psychological distress. Results: Across stratification variables of gender (F/M) and age group (primary/secondary-school-aged children), bivariate ordered probit regression revealed that being cyberbullied and nighttime phone use were independent predictors of both increased psychological distress and obtaining

Hydrogen, as a medical gas, is a promising emerging treatment for many diseases related to inflammation and oxidative stress. Molecular hydrogen can be generated through hydrogen ion reduction by a metal, and magnesium-containing effervescent tablets constitute an attractive formulation strategy for oral delivery. In this regard, saccharide-based excipients represent an important class of potential fillers with high water solubility and sweet taste. In this study, we investigated the effect of different saccharides on the morphological and mechanical properties and the disintegration of hydrogen-generating effervescent tablets prepared by dry granulation. Mannitol was found to be superior to other investigated saccharides and promoted far more rapid hydrogen generation combined with acceptable mechanical properties. In further product optimization involving investigation of lubricant effects, adipic acid was selected for the optimized tablet, due to regulatory considerations.