1. Multiple Sclerosis Patients Show Lower Bioavailable 25(OH)D and 1,25(OH)2D, but No Difference in Ratio of 25(OH)D/24,25(OH)2D and FGF23 Concentrations
- Author
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Joep Killestein, Barbara M. van Amerongen, Robert de Jonge, Mariska C. Vlot, Laura Boekel, Martin den Heijer, J.J. Kragt, Annemieke C. Heijboer, Internal medicine, Clinical chemistry, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, AII - Inflammatory diseases, Molecular cell biology and Immunology, AGEM - Endocrinology, metabolism and nutrition, APH - Aging & Later Life, Amsterdam Movement Sciences - Rehabilitation & Development, Amsterdam Movement Sciences - Restoration and Development, Laboratory for Endocrinology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, and AMS - Musculoskeletal Health
- Subjects
0301 basic medicine ,Fibroblast growth factor 23 ,medicine.medical_specialty ,Vitamin D-binding protein ,lcsh:TX341-641 ,Inflammation ,vitamin D metabolites ,multiple sclerosis ,fibroblast growth factor 23 ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Internal medicine ,vitamin D binding protein ,medicine ,Vitamin D and neurology ,Nutrition and Dietetics ,Chemistry ,Multiple sclerosis ,Binding protein ,medicine.disease ,030104 developmental biology ,Endocrinology ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,030217 neurology & neurosurgery ,Food Science ,Hormone - Abstract
Vitamin D (VitD) insufficiency is common in multiple sclerosis (MS). VitD has possible anti-inflammatory effects on the immune system. The ratio between VitD metabolites in MS patients and the severity of the disease are suggested to be related. However, the exact effect of the bone-derived hormone fibroblast-growth-factor-23 (FGF23) and VitD binding protein (VDBP) on this ratio is not fully elucidated yet. Therefore, the aim is to study differences in total, free, and bioavailable VD metabolites and FGF23 between MS patients and healthy controls (HCs). FGF23, vitD (25(OH)D), active vitD (1,25(OH)2D), inactive 24,25(OH)D, and VDBP were measured in 91 MS patients and 92 HCs. Bioavailable and free concentrations were calculated. No difference in FGF23 (p = 0.65) and 25(OH)D/24.25(OH)2D ratio (p = 0.21) between MS patients and HCs was observed. Bioavailable 25(OH)D and bioavailable 1.25(OH)2D were lower (p <, 0.01), while VDBP concentrations were higher in MS patients (p = 0.02) compared with HCs, specifically in male MS patients (p = 0.01). In conclusion, FGF23 and 25(OH)D/24.25(OH)2D did not differ between MS patients and HCs, yet bioavailable VitD concentrations are of potential clinical relevance in MS patients. The possible immunomodulating role of VDBP and gender-related differences in the VD-FGF23 axis in MS need further study.
- Published
- 2019
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