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Your search keyword '"Lupu Mihai"' showing total 21 results
Start Over Author "Lupu Mihai" Publisher mdpi ag
21 results on '"Lupu Mihai"'

14. Neuroendocrine Factors in Melanoma Pathogenesis

Author

Scheau, Cristian, primary, Draghici, Carmen, additional, Ilie, Mihaela Adriana, additional, Lupu, Mihai, additional, Solomon, Iulia, additional, Tampa, Mircea, additional, Georgescu, Simona Roxana, additional, Caruntu, Ana, additional, Constantin, Carolina, additional, Neagu, Monica, additional, and Caruntu, Constantin, additional

Published
2021
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20. The Importance of In Vivo Reflectance Confocal Microscopy in a Case of Desmoplastic Melanoma.

Author

Cristescu MI, Popa LG, Cozma EC, Celarel AM, Popa VT, Lupu M, and Voiculescu VM

Abstract

Desmoplastic melanoma accounts for 5% of all cases of melanoma, but its diagnosis can be difficult due to its frequent clinical presentation with amelanotic lesions. Histologically, spindled melanocytes surrounded by a collagenous stroma are observed. Compared with other types of melanoma, the desmoplastic types presents greater local aggression, and is more prone to local recurrence, but has a lower risk of lymph node metastasis. Early detection, accurate staging, and proper surgical management are the main factors associated with higher survival rates in melanoma patients. Reflectance confocal microscopy (RCM) has proven to be a valuable imaging tool in the diagnosis of skin neoplasms, being useful for orientating practitioners towards the diagnosis of melanoma and indicating the necessity of performing a diagnostic biopsy. We present the case of 52-year-old woman, who presented to the dermatology department with an irregular, dark-colored plaque in the right deltoid region. Dermoscopy showed asymmetry with an atypical network and some areas of regression. RCM revealed pagetoid cells in the upper epidermis, cell atypia, non-edged papillae, dermal inflammation, and nucleated cells in the dermis, which are highly suggestive of melanoma. A biopsy was also performed. A histopathology exam confirmed the diagnosis of superficially spreading melanoma with a desmoplastic component, and revealed a Breslow index of 0.9 mm, Clark level IV, an absence of mitoses, angiolymphatic invasion and regression, and complete excision. The CT and PET-CT scans were negative. A biopsy of the axillary sentinel lymph node was conducted, with a negative result obtained, establishing the IB stage of the disease. The patient will remain under follow-up to look for a recurrence or a new primary melanoma.

Published
2024
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21. A Systematic Review and Meta-Analysis of the Accuracy of in VivoReflectance Confocal Microscopy for the Diagnosis of Primary Basal Cell Carcinoma.

Author

Lupu M, Popa IM, Voiculescu VM, Caruntu A, and Caruntu C

Abstract

Basal cell carcinoma (BCC) is the most common cancer worldwide and its incidence is constantly rising. Early diagnosis and treatment can significantly reduce patient morbidity and healthcare costs. The value of reflectance confocal microscopy (RCM) in non-melanoma skin cancer diagnosis is still under debate. This systematic review and meta-analysis were conducted to assess the diagnostic accuracy of RCM in primary BCC. PubMed, Google Scholar, Scopus, and Web of Science databases were searched up to July 05, 2019, to collect articles concerning primary BCC diagnosis through RCM. The studies' methodological quality was assessed by the QUADAS-2 tool. The meta-analysis was conducted using Stata 13.0, RevMan 5.0, and MetaDisc 1.4 software. We included 15 studies totaling a number of 4163 lesions. The pooled sensitivity and specificity were 0.92 (95% CI, 0.87-0.95; I 2 = 85.27%) and 0.93 (95% CI, 0.85-0.97; I 2 = 94.61%), the pooled positive and negative likelihood ratios were 13.51 (95% CI, 5.8-31.37; I 2 = 91.01%) and 0.08 (95% CI, 0.05-0.14; I 2 = 84.83%), and the pooled diagnostic odds ratio was 160.31 (95% CI, 64.73-397.02; I 2 =71%). Despite the heterogeneity and risk of bias, this study demonstrates that RCM, through its high sensitivity and specificity, may have a significant clinical impact on the diagnosis of primary BCC., Competing Interests: The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

Published
2019
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