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22 results on '"Marini, Cecilia"'

2. Abscisic Acid and Its Receptors LANCL1 and LANCL2 Control Cardiomyocyte Mitochondrial Function, Expression of Contractile, Cytoskeletal and Ion Channel Proteins and Cell Proliferation via ERRα

Author

Spinelli, Sonia, primary, Guida, Lucrezia, additional, Passalacqua, Mario, additional, Magnone, Mirko, additional, Cossu, Vanessa, additional, Sambuceti, Gianmario, additional, Marini, Cecilia, additional, Sturla, Laura, additional, and Zocchi, Elena, additional

Published
2023
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3. Divergent Oxidative Stress in Normal Tissues and Inflammatory Cells in Hodgkin and Non-Hodgkin Lymphoma

Author

Marini, Cecilia, primary, Cossu, Vanessa, additional, Lanfranchi, Francesco, additional, Carta, Sonia, additional, Vitale, Francesca, additional, D’Amico, Francesca, additional, Bauckneht, Matteo, additional, Morbelli, Silvia, additional, Donegani, Maria Isabella, additional, Chiola, Silvia, additional, Raffa, Stefano, additional, Sofia, Luca, additional, Di Raimondo, Tania, additional, Ballerini, Filippo, additional, Ghiggi, Chiara, additional, Durando, Paolo, additional, Ravera, Silvia, additional, Riondato, Mattia, additional, Orengo, Anna Maria, additional, Bruno, Silvia, additional, Chiesa, Sabrina, additional, and Sambuceti, Gianmario, additional

Published
2023
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5. Fundamental Role of Pentose Phosphate Pathway within the Endoplasmic Reticulum in Glutamine Addiction of Triple-Negative Breast Cancer Cells

Author

Marini, Cecilia, primary, Cossu, Vanessa, additional, Carta, Sonia, additional, Greotti, Elisa, additional, Gaglio, Daniela, additional, Bertola, Nadia, additional, Chiesa, Sabrina, additional, Bruno, Silvia, additional, Vitale, Francesca, additional, Bonanomi, Marcella, additional, Porro, Danilo, additional, Riondato, Mattia, additional, Orengo, Anna Maria, additional, Bauckneht, Matteo, additional, Morbelli, Silvia, additional, Ravera, Silvia, additional, and Sambuceti, Gianmario, additional

Published
2022
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6. A High Percentage of CD16+ Monocytes Correlates with the Extent of Bone Erosion in Chronic Lymphocytic Leukemia Patients: The Impact of Leukemic B Cells in Monocyte Differentiation and Osteoclast Maturation

Author

Giannoni, Paolo, primary, Marini, Cecilia, additional, Cutrona, Giovanna, additional, Todoerti, Katia, additional, Neri, Antonino, additional, Ibatici, Adalberto, additional, Sambuceti, Gianmario, additional, Pigozzi, Simona, additional, Mora, Marco, additional, Ferrarini, Manlio, additional, Fais, Franco, additional, and de Totero, Daniela, additional

Published
2022
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7. Mitochondrial Generated Redox Stress Differently Affects the Endoplasmic Reticulum of Circulating Lymphocytes and Monocytes in Treatment-Naïve Hodgkin’s Lymphoma

Author

Marini, Cecilia, primary, Cossu, Vanessa, additional, Bauckneht, Matteo, additional, Carta, Sonia, additional, Lanfranchi, Francesco, additional, D’Amico, Francesca, additional, Ravera, Silvia, additional, Orengo, Anna Maria, additional, Ghiggi, Chiara, additional, Ballerini, Filippo, additional, Durando, Paolo, additional, Chiesa, Sabrina, additional, Miceli, Alberto, additional, Donegani, Maria Isabella, additional, Morbelli, Silvia, additional, Bruno, Silvia, additional, and Sambuceti, Gianmario, additional

Published
2022
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8. Beyond the Prognostic Value of 2-[18F]FDG PET/CT in Prostate Cancer: A Case Series and Literature Review Focusing on the Diagnostic Value and Impact on Patient Management

Author

Borea, Roberto, primary, Favero, Diletta, additional, Miceli, Alberto, additional, Donegani, Maria, additional, Raffa, Stefano, additional, Gandini, Annalice, additional, Cremante, Malvina, additional, Marini, Cecilia, additional, Sambuceti, Gianmario, additional, Zanardi, Elisa, additional, Morbelli, Silvia, additional, Fornarini, Giuseppe, additional, Rebuzzi, Sara, additional, and Bauckneht, Matteo, additional

Published
2022
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9. The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Author

Marini, Cecilia, primary, Cossu, Vanessa, additional, Kumar, Mandeep, additional, Milanese, Marco, additional, Cortese, Katia, additional, Bruno, Silvia, additional, Bellese, Grazia, additional, Carta, Sonia, additional, Zerbo, Roberta Arianna, additional, Torazza, Carola, additional, Bauckneht, Matteo, additional, Venturi, Consuelo, additional, Raffa, Stefano, additional, Orengo, Anna Maria, additional, Donegani, Maria Isabella, additional, Chiola, Silvia, additional, Ravera, Silvia, additional, Castellani, Patrizia, additional, Morbelli, Silvia, additional, Sambuceti, Gianmario, additional, and Bonanno, Giambattista, additional

Published
2021
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11. Myocardial Metabolic Response Predicts Chemotherapy Curative Potential on Hodgkin Lymphoma: A Proof-of-Concept Study

Author

Marini, Cecilia, primary, Bauckneht, Matteo, additional, Borra, Anna, additional, Lai, Rita, additional, Donegani, Maria Isabella, additional, Miceli, Alberto, additional, Campi, Cristina, additional, Cossu, Vanessa, additional, Schenone, Daniela, additional, Morbelli, Silvia, additional, Chauvie, Stephane, additional, Piana, Michele, additional, Gallamini, Andrea, additional, and Sambuceti, Gianmario, additional

Published
2021
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12. Two Novel PET Radiopharmaceuticals for Endothelial Vascular Cell Adhesion Molecule-1 (VCAM-1) Targeting

Author

Pastorino, Sara, primary, Baldassari, Sara, additional, Ailuno, Giorgia, additional, Zuccari, Guendalina, additional, Drava, Giuliana, additional, Petretto, Andrea, additional, Cossu, Vanessa, additional, Marini, Cecilia, additional, Alfei, Silvana, additional, Florio, Tullio, additional, Sambuceti, Gianmario, additional, and Caviglioli, Gabriele, additional

Published
2021
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13. The Role of the Immune Metabolic Prognostic Index in Patients with Non-Small Cell Lung Cancer (NSCLC) in Radiological Progression during Treatment with Nivolumab

Author

Bauckneht, Matteo, primary, Genova, Carlo, additional, Rossi, Giovanni, additional, Rijavec, Erika, additional, Dal Bello, Maria, additional, Ferrarazzo, Giulia, additional, Tagliamento, Marco, additional, Donegani, Maria, additional, Biello, Federica, additional, Chiola, Silvia, additional, Zullo, Lodovica, additional, Raffa, Stefano, additional, Lanfranchi, Francesco, additional, Cittadini, Giuseppe, additional, Marini, Cecilia, additional, Lopci, Egesta, additional, Sambuceti, Gianmario, additional, Grossi, Francesco, additional, and Morbelli, Silvia, additional

Published
2021
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14. Brain Metabolic Correlates of Persistent Olfactory Dysfunction after SARS-Cov2 Infection

Author

Donegani, Maria Isabella, primary, Miceli, Alberto, additional, Pardini, Matteo, additional, Bauckneht, Matteo, additional, Chiola, Silvia, additional, Pennone, Michele, additional, Marini, Cecilia, additional, Massa, Federico, additional, Raffa, Stefano, additional, Ferrarazzo, Giulia, additional, Arnaldi, Dario, additional, Sambuceti, Gianmario, additional, Nobili, Flavio, additional, and Morbelli, Silvia, additional

Published
2021
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15. 18F-Fluorodeoxyglucose Positron Emission Tomography Tracks the Heterogeneous Brain Susceptibility to the Hyperglycemia-Related Redox Stress

Author

Miceli, Alberto, primary, Cossu, Vanessa, additional, Marini, Cecilia, additional, Castellani, Patrizia, additional, Raffa, Stefano, additional, Donegani, Maria Isabella, additional, Bruno, Silvia, additional, Ravera, Silvia, additional, Emionite, Laura, additional, Orengo, Anna Maria, additional, Grillo, Federica, additional, Nobili, Flavio, additional, Morbelli, Silvia, additional, Uccelli, Antonio, additional, Sambuceti, Gianmario, additional, and Bauckneht, Matteo, additional

Published
2020
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16. The Prognostic Role of Baseline Metabolic Tumor Burden and Systemic Inflammation Biomarkers in Metastatic Castration-Resistant Prostate Cancer Patients Treated with Radium-223: A Proof of Concept Study

Author

Bauckneht, Matteo, primary, Rebuzzi, Sara Elena, additional, Signori, Alessio, additional, Donegani, Maria Isabella, additional, Murianni, Veronica, additional, Miceli, Alberto, additional, Borea, Roberto, additional, Raffa, Stefano, additional, Damassi, Alessandra, additional, Ponzano, Marta, additional, Catalano, Fabio, additional, Martelli, Valentino, additional, Marini, Cecilia, additional, Boccardo, Francesco, additional, Morbelli, Silvia, additional, Sambuceti, Gianmario, additional, and Fornarini, Giuseppe, additional

Published
2020
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17. Role of Baseline and Post-Therapy 18F-FDG PET in the Prognostic Stratification of Metastatic Castration-Resistant Prostate Cancer (mCRPC) Patients Treated with Radium-223

Author

Bauckneht, Matteo, primary, Capitanio, Selene, additional, Donegani, Maria Isabella, additional, Zanardi, Elisa, additional, Miceli, Alberto, additional, Murialdo, Roberto, additional, Raffa, Stefano, additional, Tomasello, Laura, additional, Vitti, Martina, additional, Cavo, Alessia, additional, Catalano, Fabio, additional, Mencoboni, Manlio, additional, Ceppi, Marcello, additional, Marini, Cecilia, additional, Fornarini, Giuseppe, additional, Boccardo, Francesco, additional, Sambuceti, Gianmario, additional, and Morbelli, Silvia, additional

Published
2019
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18. Assessment of Skeletal Tumor Load in Metastasized Castration-Resistant Prostate Cancer Patients: A Review of Available Methods and an Overview on Future Perspectives

Author

Fiz, Francesco, primary, Dittman, Helmut, additional, Campi, Cristina, additional, Morbelli, Silvia, additional, Marini, Cecilia, additional, Brignone, Massimo, additional, Bauckneht, Matteo, additional, Piva, Roberta, additional, Massone, Anna, additional, Piana, Michele, additional, Sambuceti, Gianmario, additional, and la Fougère, Christian, additional

Published
2018
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19. A Score-Based Approach to 18F-FDG PET Images as a Tool to Describe Metabolic Predictors of Myocardial Doxorubicin Susceptibility

Author

Bauckneht, Matteo, primary, Morbelli, Silvia, additional, Fiz, Francesco, additional, Ferrarazzo, Giulia, additional, Piva, Roberta, additional, Nieri, Alberto, additional, Sarocchi, Matteo, additional, Spallarossa, Paolo, additional, Canepari, Maria, additional, Arboscello, Eleonora, additional, Bellodi, Andrea, additional, Massaia, Massimo, additional, Gallamini, Andrea, additional, Bruzzi, Paolo, additional, Marini, Cecilia, additional, and Sambuceti, Gianmario, additional

Published
2017
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20. Beyond the Prognostic Value of 2-[ 18 F]FDG PET/CT in Prostate Cancer: A Case Series and Literature Review Focusing on the Diagnostic Value and Impact on Patient Management.

Author

Borea R, Favero D, Miceli A, Donegani MI, Raffa S, Gandini A, Cremante M, Marini C, Sambuceti G, Zanardi E, Morbelli S, Fornarini G, Rebuzzi SE, and Bauckneht M

Abstract

The role of 2-deoxy-2-[ 18 F]fluoro-D-glucose Positron Emission Tomography/Computed Tomography (FDG PET/CT) in the management of prostate cancer (PCa) patients is increasingly recognised. However, its clinical role is still controversial. Many published studies showed that FDG PET/CT might have a prognostic value in the metastatic castration-resistant phase of the disease, but its role in other settings of PCa and, more importantly, its impact on final clinical management remains to be further investigated. We describe a series of six representative clinical cases of PCa in different clinical settings, but all characterised by a measurable clinical impact of FDG PET/CT on the patients' management. Starting from their clinical history, we report a concise narrative literature review on the advantages and limitations of FDG PET/CT beyond its prognostic value in PCa. What emerges is that in selected cases, this imaging technique may represent a useful tool in managing PCa patients. However, in the absence of dedicated studies to define the optimal clinical setting of its application, no standard recommendations on its use in PCa patients can be made.

Published
2022
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21. The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1 G93A Mouse Model of Amyotrophic Lateral Sclerosis.

Author

Marini C, Cossu V, Kumar M, Milanese M, Cortese K, Bruno S, Bellese G, Carta S, Zerbo RA, Torazza C, Bauckneht M, Venturi C, Raffa S, Orengo AM, Donegani MI, Chiola S, Ravera S, Castellani P, Morbelli S, Sambuceti G, and Bonanno G

Abstract

Recent studies reported that the uptake of [18F]-fluorodeoxyglucose (FDG) is increased in the spinal cord (SC) and decreased in the motor cortex (MC) of patients with ALS, suggesting that the disease might differently affect the two nervous districts with different time sequence or with different mechanisms. Here we show that MC and SC astrocytes harvested from newborn B6SJL-Tg (SOD1 G93A ) 1Gur mice could play different roles in the pathogenesis of the disease. Spectrophotometric and cytofluorimetric analyses showed an increase in redox stress, a decrease in antioxidant capacity and a relative mitochondria respiratory uncoupling in MC SOD1 G93A astrocytes. By contrast, SC mutated cells showed a higher endurance against oxidative damage, through the increase in antioxidant defense, and a preserved respiratory function. FDG uptake reproduced the metabolic response observed in ALS patients: SOD1 G93A mutation caused a selective enhancement in tracer retention only in mutated SC astrocytes, matching the activity of the reticular pentose phosphate pathway and, thus, of hexose-6P dehydrogenase. Finally, both MC and SC mutated astrocytes were characterized by an impressive ultrastructural enlargement of the endoplasmic reticulum (ER) and impairment in ER-mitochondria networking, more evident in mutated MC than in SC cells. Thus, SOD1 G93A mutation differently impaired MC and SC astrocyte biology in a very early stage of life.

Published
2021
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22. A Score-Based Approach to 18 F-FDG PET Images as a Tool to Describe Metabolic Predictors of Myocardial Doxorubicin Susceptibility.

Author

Bauckneht M, Morbelli S, Fiz F, Ferrarazzo G, Piva R, Nieri A, Sarocchi M, Spallarossa P, Canepari ME, Arboscello E, Bellodi A, Massaia M, Gallamini A, Bruzzi P, Marini C, and Sambuceti G

Abstract

Purpose: To verify the capability of 18 F-fluorodeoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to identify patients at higher risk of developing doxorubicin (DXR)-induced cardiotoxicity, using a score-based image approach., Methods: 36 patients underwent FDG-PET/CT. These patients had shown full remission after DXR-based chemotherapy for Hodgkin's disease (DXR dose: 40-50 mg/m² per cycle), and were retrospectively enrolled. Inclusion criteria implied the presence of both pre- and post-chemotherapy clinical evaluation encompassing electrocardiogram (ECG) and echocardiography. Myocardial metabolism at pre-therapy PET was evaluated according to both standardized uptake value (SUV)- and score-based approaches. The capability of the score-based image assessment to predict the occurrence of cardiac toxicity with respect to SUV measurement was then evaluated., Results: In contrast to the SUV-based approach, the five-point scale method does not linearly stratify the risk of the subsequent development of cardiotoxicity. However, converting the five-points scale to a dichotomic evaluation (low vs. high myocardial metabolism), FDG-PET/CT showed high diagnostic accuracy in the prediction of cardiac toxicity (specificity = 100% and sensitivity = 83.3%). In patients showing high myocardial uptake at baseline, in which the score-based method is not able to definitively exclude the occurrence of cardiac toxicity, myocardial SUV mean quantification is able to further stratify the risk between low and intermediate risk classes., Conclusions: the score-based approach to FDG-PET/CT images is a feasible method for predicting DXR-induced cardiotoxicity. This method might improve the inter-reader and inter-scanner variability, thus allowing the evaluation of FDG-PET/CT images in a multicentral setting., Competing Interests: The authors declare no conflict of interest.

Published
2017
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