Search

Your search keyword '"Mercuri, Nicola Biagio"' showing total 26 results
Start Over Author "Mercuri, Nicola Biagio" Publisher mdpi ag
26 results on '"Mercuri, Nicola Biagio"'

3. Trimetazidine Improves Mitochondrial Dysfunction in SOD1G93A Cellular Models of Amyotrophic Lateral Sclerosis through Autophagy Activation

Author

Salvatori, Illari, primary, Nesci, Valentina, additional, Spalloni, Alida, additional, Marabitti, Veronica, additional, Muzzi, Maurizio, additional, Zenuni, Henri, additional, Scaricamazza, Silvia, additional, Rosina, Marco, additional, Fenili, Gianmarco, additional, Goglia, Mariangela, additional, Boffa, Laura, additional, Massa, Roberto, additional, Moreno, Sandra, additional, Mercuri, Nicola Biagio, additional, Nazio, Francesca, additional, Longone, Patrizia, additional, Ferri, Alberto, additional, and Valle, Cristiana, additional

Published
2024
Full Text
View/download PDF

5. Exploring the Association Linking Head Position and Sleep Architecture to Motor Impairment in Parkinson’s Disease: An Exploratory Study

Author

Gnarra, Oriella, primary, Calvello, Carmen, additional, Schirinzi, Tommaso, additional, Beozzo, Francesca, additional, De Masi, Claudia, additional, Spanetta, Matteo, additional, Fernandes, Mariana, additional, Grillo, Piergiorgio, additional, Cerroni, Rocco, additional, Pierantozzi, Mariangela, additional, Bassetti, Claudio L. A., additional, Mercuri, Nicola Biagio, additional, Stefani, Alessandro, additional, and Liguori, Claudio, additional

Published
2023
Full Text
View/download PDF

12. Neuropathology of the Basal Ganglia in SNCA Transgenic Rat Model of Parkinson’s Disease: Involvement of Parvalbuminergic Interneurons and Glial-Derived Neurotropic Factor

Author

Paldino, Emanuela, primary, D’angelo, Vincenza, additional, Massaro Cenere, Mariangela, additional, Guatteo, Ezia, additional, Barattucci, Simone, additional, Migliorato, Giorgia, additional, Berretta, Nicola, additional, Riess, Olaf, additional, Sancesario, Giuseppe, additional, Mercuri, Nicola Biagio, additional, and Fusco, Francesca Romana, additional

Published
2022
Full Text
View/download PDF

18. Distortion Product Otoacoustic Emissions and Their Suppression as Predictors of Peripheral Auditory Damage in Migraine: A Case-Control Study

Author

Albanese, Maria, primary, Di Girolamo, Stefano, additional, Silvani, Lorenzo, additional, Ciaschi, Eleonora, additional, Chiaramonte, Barbara, additional, Conti, Matteo, additional, Passali, Francesco Maria, additional, Di Gioia, Battista, additional, Mercuri, Nicola Biagio, additional, and Di Stadio, Arianna, additional

Published
2021
Full Text
View/download PDF

19. Complex Rearrangement of the Entire Retinal Posterior Pole in Patients with Relapsing Remitting Multiple Sclerosis

Author

Martucci, Alessio, primary, Landi, Doriana, additional, Cesareo, Massimo, additional, Di Carlo, Emiliano, additional, Di Mauro, Giovanni, additional, Sorge, Roberto Pietro, additional, Albanese, Maria, additional, Gabri Nicoletti, Carolina, additional, Mataluni, Giorgia, additional, Mercuri, Nicola Biagio, additional, Di Marino, Matteo, additional, Aiello, Francesco, additional, Centonze, Diego, additional, Nucci, Carlo, additional, Marfia, Girolama Alessandra, additional, and Mancino, Raffaele, additional

Published
2021
Full Text
View/download PDF

21. Ultramicronized Palmitoylethanolamide (um-PEA): A New Possible Adjuvant Treatment in COVID-19 patients

Author

Noce, Annalisa, primary, Albanese, Maria, additional, Marrone, Giulia, additional, Di Lauro, Manuela, additional, Pietroboni Zaitseva, Anna, additional, Palazzetti, Daniela, additional, Guerriero, Cristina, additional, Paolino, Agostino, additional, Pizzenti, Giuseppa, additional, Di Daniele, Francesca, additional, Romani, Annalisa, additional, D’Agostini, Cartesio, additional, Magrini, Andrea, additional, Mercuri, Nicola Biagio, additional, and Di Daniele, Nicola, additional

Published
2021
Full Text
View/download PDF

22. Physical Exercise and Alzheimer’s Disease: Effects on Pathophysiological Molecular Pathways of the Disease

Author

López-Ortiz, Susana, primary, Pinto-Fraga, Jose, additional, Valenzuela, Pedro L., additional, Martín-Hernández, Juan, additional, Seisdedos, María M., additional, García-López, Oscar, additional, Toschi, Nicola, additional, Di Giuliano, Francesca, additional, Garaci, Francesco, additional, Mercuri, Nicola Biagio, additional, Nisticò, Robert, additional, Emanuele, Enzo, additional, Lista, Simone, additional, Lucia, Alejandro, additional, and Santos-Lozano, Alejandro, additional

Published
2021
Full Text
View/download PDF

25. Assessment of Psychometric Characteristics of Parkinson's Disease Sleep Scale 2 and Analysis of a Cut-Off Score for Detecting Insomnia in Italian Patients with Parkinson's Disease: A Validation Study.

Author

Liguori C, Frontani F, Francescangeli G, Pierantozzi M, Cerroni R, Schirinzi T, Stefani A, Mercuri NB, and Galeoto G

Abstract

Introduction: Sleep disorders are frequent non-motor symptoms affecting patients with Parkinson's disease (PD). Insomnia represents the most common sleep disorder. Parkinson's disease Sleep Scale 2 (PDSS-2) is a specific tool to investigate sleep problems in PD. The General Sleep Disturbances Scale (GSDS) was a general scale validated for the Italian population. Our goal was to assess the psychometric characteristics of PDSS-2 and the GSDS in this population, calculating a cut-off score for insomnia symptoms by using subitems of PDSS-2., Methods: Patients admitted at the PD Unit of the Hospital of Rome Tor Vergata outpatient clinic and those afferent to PD associations were asked to complete PDSS-2 and GSDS to be correlated to identify a cut-off for insomnia symptoms. Items 1,2,3,8,13 of PDSS-2 were used to detect insomnia. An ROC curve to assess a cut-off score for insomnia was determined. A cross-cultural analysis of PD population characteristics was performed., Results: In total, 350 PD patients were recruited. Cronbach's alpha was high for the total score (0.828 for PDSS-2 and 0.832 for GSDS). A cross-cultural analysis did not show any significant p -value. The ROC curve yielded an AUC of 0.79 (CI: 0.75-0.84). The cut-off value for insomnia disorder based on items 1,2,3,8,13 of PDSS-2 was >10, demonstrating a sensitivity of 76% and a specificity of 69% in determining the presence of subjective insomnia symptoms in PD., Discussion: PDSS-2 is demonstrated to be a valid, specific tool to address sleep disturbances in PD patients. A cut-off score of 10 for items 1,2,3,8,13 was identified for detecting insomnia symptoms in PD patients.

Published
2024
Full Text
View/download PDF

26. Functional Correlates of Microglial and Astrocytic Activity in Symptomatic Sporadic Alzheimer's Disease: A CSF/ 18 F-FDG-PET Study.

Author

Bonomi CG, Chiaravalloti A, Camedda R, Ricci F, Mercuri NB, Schillaci O, Koch G, Martorana A, and Motta C

Abstract

Glial and microglial cells contribute to brain glucose consumption and could actively participate in shaping patterns of brain hypometabolism. Here, we aimed to investigate the association between 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake and markers of microglial and astrocytic activity in a cohort of patients with Alzheimer's Disease (AD). We dosed cerebrospinal fluid (CSF) levels of soluble Triggering Receptor Expressed on Myeloid cells (sTREM2), Glial Fibrillary Acidic Protein (GFAP), a marker of reactive astrogliosis, and β-S100, a calcium-binding protein associated with a neurotoxic astrocytic profile. No associations were found between sTREM-2 and 18F-FDG uptake. Instead, 18 F-FDG uptake was associated negatively with CSF β-S100 in the left supramarginal gyrus, inferior parietal lobe and middle temporal gyrus (Brodmann Areas (BA) 21 and 40). Increased β-S100 levels could negatively regulate neuronal activity in the temporo-parietal cortex to prevent damage associated with AD hyperactivity, or rather they could reflect neurotoxic astrocytic activation contributing to AD progression in key strategic areas. We also identified a trend of positive association of 18 F-FDG uptake with CSF GFAP in the right fronto-medial and precentral gyri (BA 6, 9 and 11), which has been reported in early AD and could either be persisting as an epiphenomenon tied to disease progression or be specifically aimed at preserving functions in the frontal cortex. Overall, CSF markers of astrogliosis seem to correlate with cortical glucose uptake in symptomatic sporadic AD, highlighting the role of astrocytes in shaping regional hypometabolism and possibly clinical presentation.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results