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Your search keyword '"Monza, Laura"' showing total 11 results
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11 results on '"Monza, Laura"'

1. Paclitaxel, but Not Cisplatin, Affects Satellite Glial Cells in Dorsal Root Ganglia of Rats with Chemotherapy-Induced Peripheral Neurotoxicity

Author

Pozzi, Eleonora, primary, Ballarini, Elisa, additional, Rodriguez-Menendez, Virginia, additional, Canta, Annalisa, additional, Chiorazzi, Alessia, additional, Monza, Laura, additional, Bossi, Mario, additional, Alberti, Paola, additional, Malacrida, Alessio, additional, Meregalli, Cristina, additional, Scuteri, Arianna, additional, Cavaletti, Guido, additional, and Carozzi, Valentina Alda, additional

Published
2023
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2. Morpho-Functional Characterisation of the Rat Ventral Caudal Nerve in a Model of Axonal Peripheral Neuropathy

Author

Pozzi, Eleonora, primary, Monza, Laura, additional, Ballarini, Elisa, additional, Bossi, Mario, additional, Rodriguez-Menendez, Virginia, additional, Canta, Annalisa, additional, Chiorazzi, Alessia, additional, Carozzi, Valentina Alda, additional, Crippa, Luca, additional, Marmiroli, Paola, additional, Cavaletti, Guido, additional, and Alberti, Paola, additional

Published
2023
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3. Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?

Author

Ballarini, Elisa, primary, Malacrida, Alessio, additional, Rodriguez-Menendez, Virginia, additional, Pozzi, Eleonora, additional, Canta, Annalisa, additional, Chiorazzi, Alessia, additional, Monza, Laura, additional, Semperboni, Sara, additional, Meregalli, Cristina, additional, Carozzi, Valentina Alda, additional, Hashemi, Maryamsadat, additional, Nicolini, Gabriella, additional, Scuteri, Arianna, additional, Housley, Stephen N., additional, Cavaletti, Guido, additional, and Alberti, Paola, additional

Published
2022
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4. Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics

Author

Taiarol, L, Bigogno, C, Sesana, S, Kravicz, M, Viale, F, Pozzi, E, Monza, L, Carozzi, V, Meregalli, C, Valtorta, S, Moresco, R, Koch, M, Barbugian, F, Russo, L, Dondio, G, Steinkühler, C, Re, F, Taiarol, Lorenzo, Bigogno, Chiara, Sesana, Silvia, Kravicz, Marcelo, Viale, Francesca, Pozzi, Eleonora, Monza, Laura, Carozzi, Valentina Alda, Meregalli, Cristina, Valtorta, Silvia, Moresco, Rosa Maria, Koch, Marcus, Barbugian, Federica, Russo, Laura, Dondio, Giulio, Steinkühler, Christian, Re, Francesca, Taiarol, L, Bigogno, C, Sesana, S, Kravicz, M, Viale, F, Pozzi, E, Monza, L, Carozzi, V, Meregalli, C, Valtorta, S, Moresco, R, Koch, M, Barbugian, F, Russo, L, Dondio, G, Steinkühler, C, Re, F, Taiarol, Lorenzo, Bigogno, Chiara, Sesana, Silvia, Kravicz, Marcelo, Viale, Francesca, Pozzi, Eleonora, Monza, Laura, Carozzi, Valentina Alda, Meregalli, Cristina, Valtorta, Silvia, Moresco, Rosa Maria, Koch, Marcus, Barbugian, Federica, Russo, Laura, Dondio, Giulio, Steinkühler, Christian, and Re, Francesca

Abstract

Glioblastoma is the most common and aggressive brain tumor, associated with poor prognosis and survival, representing a challenging medical issue for neurooncologists. Dysregulation of histone-modifying enzymes (HDACs) is commonly identified in many tumors and has been linked to cancer proliferation, changes in metabolism, and drug resistance. These findings led to the development of HDAC inhibitors, which are limited by their narrow therapeutic index. In this work, we provide the proof of concept for a delivery system that can improve the in vivo half-life and increase the brain delivery of Givinostat, a pan-HDAC inhibitor. Here, 150-nm-sized liposomes composed of cholesterol and sphingomyelin with or without surface decoration with mApoE peptide, inhibited human glioblastoma cell growth in 2D and 3D models by inducing a time-and dose-dependent reduction in cell viability, reduction in the receptors involved in cholesterol metabolism (from −25% to −75% of protein levels), and reduction in HDAC activity (−25% within 30 min). In addition, liposome-Givinostat formulations showed a 2.5-fold increase in the drug half-life in the bloodstream and a 6-fold increase in the amount of drug entering the brain in healthy mice, without any signs of overt toxicity. These features make liposomes loaded with Givinostat valuable as potential candidates for glioblastoma therapy.

Published
2022

5. Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics

Author

Taiarol, Lorenzo, primary, Bigogno, Chiara, additional, Sesana, Silvia, additional, Kravicz, Marcelo, additional, Viale, Francesca, additional, Pozzi, Eleonora, additional, Monza, Laura, additional, Carozzi, Valentina Alda, additional, Meregalli, Cristina, additional, Valtorta, Silvia, additional, Moresco, Rosa Maria, additional, Koch, Marcus, additional, Barbugian, Federica, additional, Russo, Laura, additional, Dondio, Giulio, additional, Steinkühler, Christian, additional, and Re, Francesca, additional

Published
2022
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6. Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity

Author

Meregalli, C, Monza, L, Chiorazzi, A, Scali, C, Guarnieri, C, Fumagalli, G, Alberti, P, Pozzi, E, Canta, A, Ballarini, E, Rodriguez-Menendez, V, Oggioni, N, Cavaletti, G, Marmiroli, P, Meregalli, Cristina, Monza, Laura, Chiorazzi, Alessia, Scali, Carla, Guarnieri, Chiara, Fumagalli, Giulia, Alberti, Paola, Pozzi, Eleonora, Canta, Annalisa, Ballarini, Elisa, Rodriguez-Menendez, Virginia, Oggioni, Norberto, Cavaletti, Guido, Marmiroli, Paola, Meregalli, C, Monza, L, Chiorazzi, A, Scali, C, Guarnieri, C, Fumagalli, G, Alberti, P, Pozzi, E, Canta, A, Ballarini, E, Rodriguez-Menendez, V, Oggioni, N, Cavaletti, G, Marmiroli, P, Meregalli, Cristina, Monza, Laura, Chiorazzi, Alessia, Scali, Carla, Guarnieri, Chiara, Fumagalli, Giulia, Alberti, Paola, Pozzi, Eleonora, Canta, Annalisa, Ballarini, Elisa, Rodriguez-Menendez, Virginia, Oggioni, Norberto, Cavaletti, Guido, and Marmiroli, Paola

Abstract

The onset of chemotherapy-induced peripheral neurotoxicity (CIPN) is a leading cause of the dose reduction or discontinuation of cancer treatment due to sensory symptoms. Paclitaxel (PTX) can cause painful peripheral neuropathy, with a negative impact on cancer survivors’ quality of life. While recent studies have shown that neuroinflammation is involved in PTX-induced peripheral neurotoxicity (PIPN), the pathophysiology of this disabling side effect remains largely unclear and no effective therapies are available. Therefore, here we investigated the effects of human intravenous immunoglobulin (IVIg) on a PIPN rat model. PTX-treated rats showed mechanical allodynia and neurophysiological alterations consistent with a severe sensory axonal polyneuropathy. In addition, morphological evaluation showed a reduction of intra-epidermal nerve fiber (IENF) density and evidenced axonopathy with macrophage infiltration, which was more prominent in the distal segment of caudal nerves. Three weeks after the last PTX injection, mechanical allodynia was still present in PTX-treated rats, while the full recovery in the group of animals co-treated with IVIg was observed. At the pathological level, this behavioral result was paralleled by prevention of the reduction in IENF density induced by PTX in IVIg co-treated rats. These results suggest that the immunomodulating effect of IVIg co-treatment can alleviate PIPN neurotoxic manifestations, probably through a partial reduction of neuroinflammation.

Published
2021

8. Human Intravenous Immunoglobulin Alleviates Neuropathic Symptoms in a Rat Model of Paclitaxel-Induced Peripheral Neurotoxicity

Author

Meregalli, Cristina, primary, Monza, Laura, additional, Chiorazzi, Alessia, additional, Scali, Carla, additional, Guarnieri, Chiara, additional, Fumagalli, Giulia, additional, Alberti, Paola, additional, Pozzi, Eleonora, additional, Canta, Annalisa, additional, Ballarini, Elisa, additional, Rodriguez-Menendez, Virginia, additional, Oggioni, Norberto, additional, Cavaletti, Guido, additional, and Marmiroli, Paola, additional

Published
2021
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9. Early Stimulation of TREK Channel Transcription and Activity Induced by Oxaliplatin-Dependent Cytosolic Acidification

Author

Dionisi, Marianna, primary, Ruffinatti, Federico Alessandro, additional, Riva, Beatrice, additional, Lim, Dmitry, additional, Canta, Annalisa, additional, Meregalli, Cristina, additional, Fumagalli, Giulia, additional, Monza, Laura, additional, Ferrer-Montiel, Antonio, additional, Fernandez-Carvajal, Asia, additional, Cavaletti, Guido, additional, Genazzani, Armando A., additional, and Distasi, Carla, additional

Published
2020
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10. Reply to a Comment Paper on the Published Paper by Canta, A. et al: “Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity”—Antioxidants 2020, 9, 594

Author

Canta, Annalisa, primary, Chiorazzi, Alessia, additional, Pozzi, Eleonora, additional, Fumagalli, Giulia, additional, Monza, Laura, additional, Meregalli, Cristina, additional, Carozzi, Valentina A., additional, Rodriguez-Menendez, Virginia, additional, Oggioni, Norberto, additional, Näsström, Jacques, additional, Marmiroli, Paola, additional, and Cavaletti, Guido, additional

Published
2020
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11. Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity

Author

Canta, Annalisa, primary, Chiorazzi, Alessia, additional, Pozzi, Eleonora, additional, Fumagalli, Giulia, additional, Monza, Laura, additional, Meregalli, Cristina, additional, Carozzi, Valentina A., additional, Rodriguez-Menendez, Virginia, additional, Oggioni, Norberto, additional, Näsström, Jacques, additional, Marmiroli, Paola, additional, and Cavaletti, Guido, additional

Published
2020
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