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11 results on '"Nassa, Giovanni"'

1. Functional Relationships between Long Non-Coding RNAs and Estrogen Receptor Alpha: A New Frontier in Hormone-Responsive Breast Cancer Management

Author

Melone, Viola, primary, Salvati, Annamaria, additional, Brusco, Noemi, additional, Alexandrova, Elena, additional, D’Agostino, Ylenia, additional, Palumbo, Domenico, additional, Palo, Luigi, additional, Terenzi, Ilaria, additional, Nassa, Giovanni, additional, Rizzo, Francesca, additional, Giurato, Giorgio, additional, Weisz, Alessandro, additional, and Tarallo, Roberta, additional

Published
2023
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2. Whole-Exome Sequencing Revealed New Candidate Genes for Human Dilated Cardiomyopathy

Author

D’Agostino, Ylenia, primary, Palumbo, Domenico, additional, Rusciano, Maria Rosaria, additional, Strianese, Oriana, additional, Amabile, Sonia, additional, Di Rosa, Domenico, additional, De Angelis, Elena, additional, Visco, Valeria, additional, Russo, Fabio, additional, Alexandrova, Elena, additional, Salvati, Annamaria, additional, Giurato, Giorgio, additional, Nassa, Giovanni, additional, Tarallo, Roberta, additional, Galasso, Gennaro, additional, Ciccarelli, Michele, additional, Weisz, Alessandro, additional, and Rizzo, Francesca, additional

Published
2022
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5. Global View of Candidate Therapeutic Target Genes in Hormone-Responsive Breast Cancer

Author

Salvati, Annamaria, primary, Gigantino, Valerio, additional, Nassa, Giovanni, additional, Mirici Cappa, Valeria, additional, Ventola, Giovanna Maria, additional, Cracas, Daniela Georgia Cristina, additional, Mastrocinque, Raffaella, additional, Rizzo, Francesca, additional, Tarallo, Roberta, additional, Weisz, Alessandro, additional, and Giurato, Giorgio, additional

Published
2020
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6. Insights into the Role of Estrogen Receptor β in Triple-Negative Breast Cancer

Author

Sellitto, Assunta, primary, D’Agostino, Ylenia, additional, Alexandrova, Elena, additional, Lamberti, Jessica, additional, Pecoraro, Giovanni, additional, Memoli, Domenico, additional, Rocco, Domenico, additional, Coviello, Elena, additional, Giurato, Giorgio, additional, Nassa, Giovanni, additional, Tarallo, Roberta, additional, Weisz, Alessandro, additional, and Rizzo, Francesca, additional

Published
2020
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7. An Overview of Candidate Therapeutic Target Genes in Ovarian Cancer

Author

Alexandrova, Elena, primary, Pecoraro, Giovanni, additional, Sellitto, Assunta, additional, Melone, Viola, additional, Ferravante, Carlo, additional, Rocco, Teresa, additional, Guacci, Anna, additional, Giurato, Giorgio, additional, Nassa, Giovanni, additional, Rizzo, Francesca, additional, Weisz, Alessandro, additional, and Tarallo, Roberta, additional

Published
2020
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8. Small Non-Coding RNA Profiling Identifies miR-181a-5p as a Mediator of Estrogen Receptor Beta-Induced Inhibition of Cholesterol Biosynthesis in Triple-Negative Breast Cancer

Author

Alexandrova, Elena, primary, Lamberti, Jessica, additional, Saggese, Pasquale, additional, Pecoraro, Giovanni, additional, Memoli, Domenico, additional, Mirici Cappa, Valeria, additional, Ravo, Maria, additional, Iorio, Roberta, additional, Tarallo, Roberta, additional, Rizzo, Francesca, additional, Collina, Francesca, additional, Cantile, Monica, additional, Di Bonito, Maurizio, additional, Botti, Gerardo, additional, Nassa, Giovanni, additional, Weisz, Alessandro, additional, and Giurato, Giorgio, additional

Published
2020
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11. Whole-Exome Sequencing Revealed New Candidate Genes for Human Dilated Cardiomyopathy.

Author

D'Agostino Y, Palumbo D, Rusciano MR, Strianese O, Amabile S, Di Rosa D, De Angelis E, Visco V, Russo F, Alexandrova E, Salvati A, Giurato G, Nassa G, Tarallo R, Galasso G, Ciccarelli M, Weisz A, and Rizzo F

Abstract

Dilated cardiomyopathy (DCM) is a complex disease affecting young adults. It is a pathological condition impairing myocardium activity that leads to heart failure and, in the most severe cases, transplantation, which is currently the only possible therapy for the disease. DCM can be attributed to many genetic determinants interacting with environmental factors, resulting in a highly variable phenotype. Due to this complexity, the early identification of causative gene mutations is an important goal to provide a genetic diagnosis, implement pre-symptomatic interventions, and predict prognosis. The advent of next-generation sequencing (NGS) has opened a new path for mutation screening, and exome sequencing provides a promising approach for identifying causal variants in known genes and novel disease-associated candidates. We analyzed the whole-exome sequencing (WES) of 15 patients affected by DCM without overloading (hypertension, valvular, or congenital heart disease) or chronic ischemic conditions. We identified 70 pathogenic or likely pathogenic variants and 1240 variants of uncertain clinical significance. Gene ontology enrichment analysis was performed to assess the potential connections between affected genes and biological or molecular function, identifying genes directly related to extracellular matrix organization, transcellular movement through the solute carrier and ATP-binding cassette transporter, and vitamin B12 metabolism. We found variants in genes implicated to a different extent in cardiac function that may represent new players in the complex genetic scenario of DCM.

Published
2022
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