1. Seaweed Dietary Fiber Sodium Alginate Suppresses the Migration of Colonic Inflammatory Monocytes and Diet-Induced Metabolic Syndrome via the Gut Microbiota
- Author
-
Yun Gi Kim, Akiyoshi Hirayama, Hiroki Sato, Masahiro Akiyama, Tatsuki Kimizuka, Koji Hase, Kyosuke Yakabe, Sawako Tomioka, Ryuta Ejima, Yumiko Fujimura, Natsumi Seki, and Shinji Fukuda
- Subjects
Dietary Fiber ,medicine.medical_specialty ,Alginates ,medicine.drug_class ,Antibiotics ,Decreased body weight ,Gut flora ,Diet, High-Fat ,digestive system ,Monocytes ,Article ,metabolic syndrome ,Mice ,chemistry.chemical_compound ,Internal medicine ,medicine ,Animals ,TX341-641 ,Cells, Cultured ,Sodium alginate ,Inflammation ,Nutrition and Dietetics ,gut microbiota ,biology ,Nutrition. Foods and food supply ,Cholesterol ,digestive, oral, and skin physiology ,inflammatory monocytes ,food and beverages ,Seaweed ,biology.organism_classification ,medicine.disease ,Gastrointestinal Microbiome ,Mice, Inbred C57BL ,Endocrinology ,chemistry ,Dietary fiber ,Bacteroides ,Metabolic syndrome ,Food Science - Abstract
Metabolic syndrome (MetS) is a multifactorial chronic metabolic disorder that affects approximately one billion people worldwide. Recent studies have evaluated whether targeting the gut microbiota can prevent MetS. This study aimed to assess the ability of dietary fiber to control MetS by modulating gut microbiota composition. Sodium alginate (SA) is a seaweed-derived dietary fiber that suppresses high-fat diet (HFD)-induced MetS via an effect on the gut microbiota. We observed that SA supplementation significantly decreased body weight gain, cholesterol levels, and fat weight, while improving glucose tolerance in HFD-fed mice. SA changed the gut microbiota composition and significantly increased the abundance of Bacteroides. Antibiotic treatment completely abolished the suppressive effects of SA on MetS. Mechanistically, SA decreased the number of colonic inflammatory monocytes, which promote MetS development, in a gut microbiota-dependent manner. The abundance of Bacteroides was negatively correlated with that of inflammatory monocytes and positively correlated with the levels of several gut metabolites. The present study revealed a novel food function of SA in preventing HFD-induced MetS through its action on gut microbiota.
- Published
- 2021
- Full Text
- View/download PDF