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Your search keyword '"Nimsky, Christopher"' showing total 28 results
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28 results on '"Nimsky, Christopher"'

3. The Feasibility and Accuracy of Holographic Navigation with Laser Crosshair Simulator Registration on a Mixed-Reality Display

Author

Qi, Ziyu, primary, Jin, Haitao, additional, Wang, Qun, additional, Gan, Zhichao, additional, Xiong, Ruochu, additional, Zhang, Shiyu, additional, Liu, Minghang, additional, Wang, Jingyue, additional, Ding, Xinyu, additional, Chen, Xiaolei, additional, Zhang, Jiashu, additional, Nimsky, Christopher, additional, and Bopp, Miriam H. A., additional

Published
2024
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5. Implementation and Assessment of a Laparotomy-Assisted Three-Port Fetoscopic Spina Bifida Repair Program

Author

Keil, Corinna, primary, Köhler, Siegmund, additional, Sass, Benjamin, additional, Schulze, Maximilian, additional, Kalmus, Gerald, additional, Belfort, Michael, additional, Schmitt, Nicolas, additional, Diehl, Daniele, additional, King, Alice, additional, Groß, Stefanie, additional, Sutton, Caitlin D., additional, Joyeux, Luc, additional, Wege, Mirjam, additional, Nimsky, Christopher, additional, Whitehead, Wiliam E., additional, Uhl, Eberhard, additional, Huisman, Thierry A. G. M., additional, Neubauer, Bernd A., additional, Weber, Stefanie, additional, Hummler, Helmut, additional, Axt-Fliedner, Roland, additional, and Bedei, Ivonne, additional

Published
2023
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8. Targeting Aggressive Pituitary Adenomas at the Molecular Level—A Review

Author

Voellger, Benjamin, Zhang, Zhuo, Benzel, Julia, Wang, Junwen, Lei, Ting, Nimsky, Christopher, and Bartsch, Jörg-Walter

Subjects
invasiveness, proliferation, adjuvant treatment, molecular biology, Medicine, Review, pituitary adenomas, hormone secretion
Abstract

Pituitary adenomas (PAs) are mostly benign endocrine tumors that can be treated by resection or medication. However, up to 10% of PAs show an aggressive behavior with invasion of adjacent tissue, rapid proliferation, or recurrence. Here, we provide an overview of target structures in aggressive PAs and summarize current clinical trials including, but not limited to, PAs. Mainly, drug targets in PAs are based on general features of tumor cells such as immune checkpoints, so that programmed cell death 1 (ligand 1) (PD-1/PD-L1) targeting may bear potential to cure aggressive PAs. In addition, epidermal growth factor receptor (EGFR), mammalian target of rapamycin (mTOR), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and their downstream pathways are triggered in PAs, thereby modulating tumor cell proliferation, migration and/or tumor angiogenesis. Temozolomide (TMZ) can be an effective treatment of aggressive PAs. Combination of TMZ with 5-Fluorouracil (5-FU) or with radiotherapy could strengthen the therapeutic effects as compared to TMZ alone. Dopamine agonists (DAs) are the first line treatment for prolactinomas. Dopamine receptors are also expressed in other subtypes of PAs which renders Das potentially suitable to treat other subtypes of PAs. Furthermore, targeting the invasive behavior of PAs could improve therapy. In this regard, human matrix metalloproteinase (MMP) family members and estrogens receptors (ERs) are highly expressed in aggressive PAs, and numerous studies demonstrated the role of these proteins to modulate invasiveness of PAs. This leaves a number of treatment options for aggressive PAs as reviewed here.

Published
2022

9. The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma

Author

Liu, Xiaojin, primary, Huang, Yimin, additional, Qi, Yiwei, additional, Wu, Shiqiang, additional, Hu, Feng, additional, Wang, Junwen, additional, Shu, Kai, additional, Zhang, Huaqiu, additional, Bartsch, Jörg W., additional, Nimsky, Christopher, additional, Dong, Fangyong, additional, and Lei, Ting, additional

Published
2022
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11. Eltanexor Effectively Reduces Viability of Glioblastoma and Glioblastoma Stem-Like Cells at Nano-Molar Concentrations and Sensitizes to Radiotherapy and Temozolomide

Author

Otte, Katharina, primary, Zhao, Kai, additional, Braun, Madita, additional, Neubauer, Andreas, additional, Raifer, Hartmann, additional, Helmprobst, Frederik, additional, Barrera, Felipe Ovalle, additional, Nimsky, Christopher, additional, Bartsch, Jörg W., additional, and Rusch, Tillmann, additional

Published
2022
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18. Neurosurgical Management and Outcome Parameters in 237 Patients with Spondylodiscitis

Author

Pojskić, Mirza, Carl, Barbara, Schmöckel, Vincent, Völlger, Benjamin, Nimsky, Christopher, and Saβ, Benjamin

Subjects
spinal empyema, antibiotic therapy, osteomyelitis, Neurosciences. Biological psychiatry. Neuropsychiatry, operative therapy, spondylodiscitis, spine, Article, infection, RC321-571
Abstract

Surgical treatment of spondylodiscitis allows for rapid mobilization and shortens hospital stays, which makes surgical treatment the first-line therapy. We aim to describe our experiences with operative treatment on spondylodiscitis and to determine the parameters that are important in the prediction of outcomes. A retrospective review identified 237 patients who were operatively treated for spondylodiscitis in our institution between January 2010 and December 2018. Clinical data were collected through review of electronic records and relevant imaging. In all cases, contrast-enhancing MRI from the infected region of the spine was obtained. Leukocyte count and C-reactive protein concentrations (CRP) were determined in all the patients. We included 237 patients in the study, 87 female (36.7%) and 150 male (63.3%), with a mean age of 71.4 years. Mean follow-up was 31.6 months. Forty-five patients had spondylodiscitis of the cervical, 73 of the thoracic, and 119 of the lumbosacral spine. All the patients with spondylodiscitis of the cervical spine received instrumentation. In thoracic and lumbar spine decompression, surgery without instrumentation was performed in 26 patients as immediate surgery and in a further 28 patients in the early stages following admission, while 138 patients received instrumentation. Eighty-nine patients (37.6%) had concomitant infections. Infection healing occurred in 89% of patients. Favorable outcomes were noted in patients without concomitant infections, with a normalized CRP value and in patients who received antibiotic therapy for more than six weeks (p < 0.05). Unfavorable outcomes were noted in patients with high CRP, postoperative spondylodiscitis, and recurrent spondylodiscitis (p < 0.05). Application of antibiotic therapy for more than six weeks and normalized CRP showed a correlation with favorable outcomes, whereas concomitant infections showed a correlation with unfavorable outcomes. A detailed screening for concomitant infectious diseases is recommended.

Published
2021

26. Comparative Transcriptomic Analysis of Temozolomide Resistant Primary GBM Stem-Like Cells and Recurrent GBM Identifies Up-Regulation of the Carbonic Anhydrase CA2 Gene as Resistance Factor

Author

Hannen, Ricarda, primary, Selmansberger, Martin, additional, Hauswald, Maria, additional, Pagenstecher, Axel, additional, Nist, Andrea, additional, Stiewe, Thorsten, additional, Acker, Till, additional, Carl, Barbara, additional, Nimsky, Christopher, additional, and Bartsch, Jörg Walter, additional

Published
2019
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27. Extended Reality-Based Head-Mounted Displays for Surgical Education: A Ten-Year Systematic Review.

Author

Qi Z, Corr F, Grimm D, Nimsky C, and Bopp MHA

Abstract

Surgical education demands extensive knowledge and skill acquisition within limited time frames, often limited by reduced training opportunities and high-pressure environments. This review evaluates the effectiveness of extended reality-based head-mounted display (ExR-HMD) technology in surgical education, examining its impact on educational outcomes and exploring its strengths and limitations. Data from PubMed, Cochrane Library, Web of Science, ScienceDirect, Scopus, ACM Digital Library, IEEE Xplore, WorldCat, and Google Scholar (Year: 2014-2024) were synthesized. After screening, 32 studies comparing ExR-HMD and traditional surgical training methods for medical students or residents were identified. Quality and bias were assessed using the Medical Education Research Study Quality Instrument, Newcastle-Ottawa Scale-Education, and Cochrane Risk of Bias Tools. Results indicate that ExR-HMD offers benefits such as increased immersion, spatial awareness, and interaction and supports motor skill acquisition theory and constructivist educational theories. However, challenges such as system fidelity, operational inconvenience, and physical discomfort were noted. Nearly half the studies reported outcomes comparable or superior to traditional methods, emphasizing the importance of social interaction. Limitations include study heterogeneity and English-only publications. ExR-HMD shows promise but needs educational theory integration and social interaction. Future research should address technical and economic barriers to global accessibility.

Published
2024
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28. Initial Intraoperative Experience with Robotic-Assisted Pedicle Screw Placement with Cirq ® Robotic Alignment: An Evaluation of the First 70 Screws.

Author

Pojskić M, Bopp M, Nimsky C, Carl B, and Saβ B

Abstract

Background: Robot-guided spine surgery is based on a preoperatively planned trajectory that is reproduced in the operating room by the robotic device. This study presents our initial experience with thoracolumbar pedicle screw placement using Brainlab's Cirq ® surgeon-controlled robotic arm (BrainLab, Munich, Germany)., Methods: All patients who underwent robotic-assisted implantation of pedicle screws in the thoracolumbar spine were included in the study. Our workflow, consisting of preoperative imagining, screw planning, intraoperative imaging with automatic registration, fusion of the preoperative and intraoperative imaging with a review of the preplanned screw trajectories, robotic-assisted insertion of K-wires, followed by a fluoroscopy-assisted insertion of pedicle screws and control iCT scan, is described., Results: A total of 12 patients (5 male and 7 females, mean age 67.4 years) underwent 13 surgeries using the Cirq ® Robotic Alignment Module for thoracolumbar pedicle screw implantation. Spondylodiscitis, metastases, osteoporotic fracture, and spinal canal stenosis were detected. A total of 70 screws were implanted. The mean time per screw was 08:27 ± 06:54 min. The mean time per screw for the first 7 surgeries (first 36 screws) was 16:03 ± 09:32 min and for the latter 6 surgeries (34 screws) the mean time per screw was 04:35 ± 02:11 min ( p < 0.05). Mean entry point deviation was 1.9 ± 1.23 mm, mean deviation from the tip of the screw was 2.61 ± 1.6 mm and mean angular deviation was 3.5° ± 2°. For screw-placement accuracy we used the CT-based Gertzbein and Robbins System (GRS). Of the total screws, 65 screws were GRS A screws (92.85%), one screw was a GRS B screw, and two further screws were grade C. Two screws were D screws (2.85%) and underwent intraoperative revision. There were no perioperative deficits., Conclusion: Brainlab's Cirq ® Robotic Alignment surgeon-controlled robotic arm is a safe and beneficial method for accurate thoracolumbar pedicle screw placement with high accuracy.

Published
2021
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