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20 results on '"Park, Jong-Tae"'

4. Isolation, Physicochemical Characterization, and Biological Properties of Inotodiol, the Potent Pharmaceutical Oxysterol from Chaga Mushroom

Author

Nguyen, Phu Cuong, primary, Nguyen, My Tuyen Thi, additional, Truong, Ba Tai, additional, Kim, Dae-Ryeol, additional, Shin, Sujin, additional, Kim, Ju-Eun, additional, Park, Kyu-Been, additional, Park, Ji-Hyun, additional, Tran, Phuong Lan, additional, Ban, So-Young, additional, Kim, Jaehan, additional, and Park, Jong-Tae, additional

Published
2023
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17. Anthocyanin-Rich Extract from Red Chinese Cabbage Alleviates Vascular Inflammation in Endothelial Cells and Apo E−/− Mice

Author

Kyu Been Park, Byeong Hwa Jeon, Myoung Soo Park, Yong Pyo Lim, Park Jong Tae, Eun Ok Lee, Yu Ran Lee, Hee Kyoung Joo, Sunga Choi, and Cuk-Seong Kim

Subjects
0301 basic medicine, Apolipoprotein E, Male, Apolipoprotein B, Anthocyanins, lcsh:Chemistry, Mice, vascular inflammation, lcsh:QH301-705.5, Spectroscopy, Aorta, biology, Cell adhesion molecule, Chemistry, General Medicine, Computer Science Applications, Cytokines, Tumor necrosis factor alpha, medicine.symptom, in vivo imaging, anthocyanin-rich red Chinese cabbage, apolipoprotein E-deficient mice, vascular cellular adhesion molecule, Immunocytochemistry, Vascular Cell Adhesion Molecule-1, Inflammation, Brassica, Catalysis, Article, Proinflammatory cytokine, Inorganic Chemistry, 03 medical and health sciences, Immune system, Apolipoproteins E, Cell Line, Tumor, medicine, Human Umbilical Vein Endothelial Cells, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, Plant Extracts, Organic Chemistry, Atherosclerosis, Molecular biology, 030104 developmental biology, HEK293 Cells, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Endothelium, Vascular
Abstract

Anthocyanins, the most prevalent flavonoids in red/purple fruits and vegetables, are known to improve immune responses and reduce chronic disease risks. In this study, the anti-inflammatory activities of an anthocyanin-rich extract from red Chinese cabbage (ArCC) were shown based on its inhibitory effects in cultured endothelial cells and hyperlipidemic apolipoprotein E-deficient mice. ArCC treatment suppressed monocyte adhesion to tumor necrosis factor-α-stimulated endothelial cells. This was validated by ArCC’s ability to downregulate the expression and transcription of endothelial adhesion molecules, determined by immunoblot and luciferase promoter assays, respectively. The regulation of adhesion molecules was accompanied by transcriptional inhibition of nuclear factor-κB, which restricted cytoplasmic localization as shown by immunocytochemistry. Administration of ArCC (150 or 300 mg/kg/day) inhibited aortic inflammation in hyperlipidemic apolipoprotein E-deficient mice, as shown by in vivo imaging. Immunohistochemistry and plasma analysis showed that the aortas from these mice exhibited markedly lower leukocyte infiltration, reduced plaque formation, and lower concentrations of blood inflammatory cytokines than those observed in the control mice. The results suggest that the consumption of anthocyanin-rich red Chinese cabbage is closely correlated with lowering the risk of vascular inflammatory diseases.

Published
2018

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