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Your search keyword '"Patruno, Leonardo"' showing total 4 results
Start Over Author "Patruno, Leonardo" Publisher mdpi ag
4 results on '"Patruno, Leonardo"'

3. Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status

Author

Irelli, Azzurra, primary, Parisi, Alessandro, additional, D’Orazio, Carla, additional, Sidoni, Tina, additional, Rotondaro, Silvia, additional, Patruno, Leonardo, additional, Pavese, Francesco, additional, Bafile, Alberto, additional, Resta, Valter, additional, Pizzorno, Laura, additional, Ciuffetelli, Virginia, additional, Dalmas, Antonella, additional, Calvisi, Giuseppe, additional, Di Sibio, Alessandra, additional, Marzullo, Anna, additional, Zelli, Veronica, additional, Compagnoni, Chiara, additional, Tessitore, Alessandra, additional, Alesse, Edoardo, additional, Ficorella, Corrado, additional, Cortellini, Alessio, additional, and Cannita, Katia, additional

Published
2022
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4. Role of Breast Cancer Risk Estimation Models to Identify Women Eligible for Genetic Testing and Risk-Reducing Surgery.

Author

Irelli A, Patruno LV, Chiatamone Ranieri S, Di Giacomo D, Malatesta S, Alesse E, Tessitore A, and Cannita K

Abstract

Hereditary breast and ovarian cancer (HBOC) syndrome is responsible for approximately 10% of breast cancers (BCs). The HBOC gene panel includes both high-risk genes, i.e., a four times higher risk of BC ( BRCA1 , BRCA2 , PALB2 , CDH1 , PTEN , STK11 and TP53 ), and moderate-risk genes, i.e., a two to four times higher risk of BC ( BARD1 , CHEK2 , RAD51C , RAD51D and ATM ). Pathogenic germline variants (PGVs) in HBOC genes confer an absolute risk of BC that changes according to the gene considered. We illustrate and compare different BC risk estimation models, also describing their limitations. These models allow us to identify women eligible for genetic testing and possibly to offer surgical strategies for primary prevention, i.e., risk-reducing mastectomies and salpingo-oophorectomies.

Published
2024
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