Search

Your search keyword '"Perissutti, Elisa"' showing total 16 results
Start Over Author "Perissutti, Elisa" Publisher mdpi ag
16 results on '"Perissutti, Elisa"'

1. 3-Nitroatenolol: First Synthesis, Chiral Resolution and Enantiomers’ Absolute Configuration

Author

Sparaco, Rosa, primary, Cinque, Pierfrancesco, additional, Scognamiglio, Antonia, additional, Corvino, Angela, additional, Caliendo, Giuseppe, additional, Fiorino, Ferdinando, additional, Magli, Elisa, additional, Perissutti, Elisa, additional, Santagada, Vincenzo, additional, Severino, Beatrice, additional, Luciano, Paolo, additional, Casertano, Marcello, additional, Aiello, Anna, additional, Martins Viegas, Gustavo Yuri, additional, De Nucci, Gilberto, additional, and Frecentese, Francesco, additional

Published
2024
Full Text
View/download PDF

2. Design, Synthesis and Biological Evaluation of Novel N-Arylpiperazines Containing a 4,5-Dihydrothiazole Ring

Author

Andreozzi, Giorgia, primary, Ambrosio, Maria Rosaria, additional, Magli, Elisa, additional, Maneli, Giovanni, additional, Severino, Beatrice, additional, Corvino, Angela, additional, Sparaco, Rosa, additional, Perissutti, Elisa, additional, Frecentese, Francesco, additional, Santagada, Vincenzo, additional, Leśniak, Anna, additional, Bujalska-Zadrożny, Magdalena, additional, Caliendo, Giuseppe, additional, Formisano, Pietro, additional, and Fiorino, Ferdinando, additional

Published
2023
Full Text
View/download PDF

3. Synthesis, Chiral Resolution and Enantiomers Absolute Configuration of 4-Nitropropranolol and 7-Nitropropranolol

Author

Sparaco, Rosa, primary, Scognamiglio, Antonia, additional, Corvino, Angela, additional, Caliendo, Giuseppe, additional, Fiorino, Ferdinando, additional, Magli, Elisa, additional, Perissutti, Elisa, additional, Santagada, Vincenzo, additional, Severino, Beatrice, additional, Luciano, Paolo, additional, Casertano, Marcello, additional, Aiello, Anna, additional, De Nucci, Gilberto, additional, and Frecentese, Francesco, additional

Published
2022
Full Text
View/download PDF

4. Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors

Author

Sparaco, Rosa, primary, Citi, Valentina, additional, Magli, Elisa, additional, Martelli, Alma, additional, Piragine, Eugenia, additional, Calderone, Vincenzo, additional, Andreozzi, Giorgia, additional, Perissutti, Elisa, additional, Frecentese, Francesco, additional, Santagada, Vincenzo, additional, Caliendo, Giuseppe, additional, Severino, Beatrice, additional, Corvino, Angela, additional, and Fiorino, Ferdinando, additional

Published
2022
Full Text
View/download PDF

5. Synthesis, Docking Studies and Pharmacological Evaluation of Serotoninergic Ligands Containing a 5-Norbornene-2-Carboxamide Nucleus

Author

Sparaco, Rosa, primary, Kędzierska, Ewa, additional, Kaczor, Agnieszka A., additional, Bielenica, Anna, additional, Magli, Elisa, additional, Severino, Beatrice, additional, Corvino, Angela, additional, Gibuła-Tarłowska, Ewa, additional, Kotlińska, Jolanta H., additional, Andreozzi, Giorgia, additional, Luciano, Paolo, additional, Perissutti, Elisa, additional, Frecentese, Francesco, additional, Casertano, Marcello, additional, Leśniak, Anna, additional, Bujalska-Zadrożny, Magdalena, additional, Oziębło, Małgorzata, additional, Capasso, Raffaele, additional, Santagada, Vincenzo, additional, Caliendo, Giuseppe, additional, and Fiorino, Ferdinando, additional

Published
2022
Full Text
View/download PDF

6. H2S Donors and Their Use in Medicinal Chemistry

Author

Magli, Elisa, primary, Perissutti, Elisa, additional, Santagada, Vincenzo, additional, Caliendo, Giuseppe, additional, Corvino, Angela, additional, Esposito, Gianluca, additional, Esposito, Giovanna, additional, Fiorino, Ferdinando, additional, Migliaccio, Marco, additional, Scognamiglio, Antonia, additional, Severino, Beatrice, additional, Sparaco, Rosa, additional, and Frecentese, Francesco, additional

Published
2021
Full Text
View/download PDF

7. Antagonizing S1P3 Receptor with Cell-Penetrating Pepducins in Skeletal Muscle Fibrosis

Author

Corvino, Angela, primary, Cerqua, Ida, additional, Lo Bianco, Alessandra, additional, Caliendo, Giuseppe, additional, Fiorino, Ferdinando, additional, Frecentese, Francesco, additional, Magli, Elisa, additional, Morelli, Elena, additional, Perissutti, Elisa, additional, Santagada, Vincenzo, additional, Cirino, Giuseppe, additional, Granato, Elisabetta, additional, Roviezzo, Fiorentina, additional, Puliti, Elisa, additional, Bernacchioni, Caterina, additional, Lavecchia, Antonio, additional, Donati, Chiara, additional, and Severino, Beatrice, additional

Published
2021
Full Text
View/download PDF

9. Heavy Metals Size Distribution in PM10 and Environmental-Sanitary Risk Analysis in Acerra (Italy)

Author

Di Vaio, Paola, primary, Magli, Elisa, additional, Caliendo, Giuseppe, additional, Corvino, Angela, additional, Fiorino, Ferdinando, additional, Frecentese, Francesco, additional, Saccone, Irene, additional, Santagada, Vincenzo, additional, Severino, Beatrice, additional, Onorati, Giuseppe, additional, D’Onofrio Freda, Giuseppina, additional, Manzo, Cosimo, additional, and Perissutti, Elisa, additional

Published
2018
Full Text
View/download PDF

10. Development of 1,2,3-Triazole-Based Sphingosine Kinase Inhibitors and Their Evaluation as Antiproliferative Agents

Author

Corvino, Angela, primary, Rosa, Roberta, additional, Incisivo, Giuseppina, additional, Fiorino, Ferdinando, additional, Frecentese, Francesco, additional, Magli, Elisa, additional, Perissutti, Elisa, additional, Saccone, Irene, additional, Santagada, Vincenzo, additional, Cirino, Giuseppe, additional, Riemma, Maria, additional, Temussi, Piero, additional, Ciciola, Paola, additional, Bianco, Roberto, additional, Caliendo, Giuseppe, additional, Roviezzo, Fiorentina, additional, and Severino, Beatrice, additional

Published
2017
Full Text
View/download PDF

11. Chemical Composition of PM10 at Urban Sites in Naples (Italy)

Author

Di Vaio, Paola, primary, Magli, Elisa, additional, Barbato, Francesco, additional, Caliendo, Giuseppe, additional, Cocozziello, Beatrice, additional, Corvino, Angela, additional, De Marco, Anna, additional, Fiorino, Ferdinando, additional, Frecentese, Francesco, additional, Onorati, Giuseppe, additional, Saccone, Irene, additional, Santagada, Vincenzo, additional, Soggiu, Maria, additional, Severino, Beatrice, additional, and Perissutti, Elisa, additional

Published
2016
Full Text
View/download PDF

12. Solomonsterol A, a Marine Pregnane-X-Receptor Agonist, Attenuates Inflammation and Immune Dysfunction in a Mouse Model of Arthritis

Author

Mencarelli, Andrea, primary, D'Amore, Claudio, additional, Renga, Barbara, additional, Cipriani, Sabrina, additional, Carino, Adriana, additional, Sepe, Valentina, additional, Perissutti, Elisa, additional, D'Auria, Maria, additional, Zampella, Angela, additional, Distrutti, Eleonora, additional, and Fiorucci, Stefano, additional

Published
2013
Full Text
View/download PDF

13. Design, Synthesis and Evaluation of Novel Molecular Hybrids between Antiglaucoma Drugs and H2S Donors

Author

Rosa Sparaco, Valentina Citi, Elisa Magli, Alma Martelli, Eugenia Piragine, Vincenzo Calderone, Giorgia Andreozzi, Elisa Perissutti, Francesco Frecentese, Vincenzo Santagada, Giuseppe Caliendo, Beatrice Severino, Angela Corvino, Ferdinando Fiorino, Sparaco, Rosa, Citi, Valentina, Magli, Elisa, Martelli, Alma, Piragine, Eugenia, Calderone, Vincenzo, Andreozzi, Giorgia, Perissutti, Elisa, Frecentese, Francesco, Santagada, Vincenzo, Caliendo, Giuseppe, Severino, Beatrice, Corvino, Angela, and Fiorino, Ferdinando

Subjects
antiglaucoma drug, molecular hybrids, H2S donor, Organic Chemistry, hydrogen sulfide, glaucoma, H2S donors, antiglaucoma drugs, General Medicine, Catalysis, Computer Science Applications, Inorganic Chemistry, Physical and Theoretical Chemistry, Molecular Biology, Spectroscopy
Abstract

Glaucoma is a group of eye diseases consisting of optic nerve damage with corresponding loss of field vision and blindness. Hydrogen sulfide (H2S) is a gaseous neurotransmitter implicated in various pathophysiological processes. It is involved in the pathological mechanism of glaucomatous neuropathy and exerts promising effects in the treatment of this disease. In this work, we designed and synthetized new molecular hybrids between antiglaucoma drugs and H2S donors to combine the pharmacological effect of both moieties, providing a heightened therapy. Brinzolamide, betaxolol and brimonidine were linked to different H2S donors. The H2S-releasing properties of the new compounds were evaluated in a phosphate buffer solution by the amperometric approach, and evaluated in human primary corneal epithelial cells (HCEs) by spectrofluorometric measurements. Experimental data showed that compounds 1c, 1d and 3d were the hybrids with the best properties, characterized by a significant and long-lasting production of the gasotransmitter both in the aqueous solution (in the presence of L-cysteine) and in the intracellular environment. Because, to date, the donation of H2S by antiglaucoma H2S donor hybrids using non-immortalized corneal cells has never been reported, these results pave the way to further investigation of the potential efficacy of the newly synthesized compounds.

Published
2022
Full Text
View/download PDF

14. Heavy Metals Size Distribution in PM10 and Environmental-Sanitary Risk Analysis in Acerra (Italy)

Author

Paola Di Vaio, Elisa Perissutti, Beatrice Severino, Francesco Frecentese, Angela Corvino, Giuseppina D’Onofrio Freda, Vincenzo Santagada, Cosimo Manzo, Elisa Magli, Giuseppe Onorati, Ferdinando Fiorino, Giuseppe Caliendo, Irene Saccone, DI VAIO, Paola, Magli, Elisa, Caliendo, Giuseppe, Corvino, Angela, Fiorino, Ferdinando, Frecentese, Francesco, Saccone, Irene, Santagada, Vincenzo, Severino, Beatrice, Onorati, Giuseppe, D'Onofrio Freda, Giuseppina, Manzo, Cosimo, and Perissutti, Elisa

Subjects
Atmospheric Science, 010504 meteorology & atmospheric sciences, principal component analysis, risk analysis, enrichment factor, 010501 environmental sciences, Environmental Science (miscellaneous), lcsh:QC851-999, 01 natural sciences, PM10, Risk analysis (business), Industrial site, medicine, Health risk, heavy metals, 0105 earth and related environmental sciences, Heavy metals, Seasonality, medicine.disease, Hazard quotient, Environmental chemistry, Environmental science, lcsh:Meteorology. Climatology, Enrichment factor, Cancer risk
Abstract

The present research has been focused on the evaluation of seasonal changes in mass concentrations and compositions of heavy metals in Particular Matters (PM)10 collected from a typical urban-industrial site in Acerra, a city located in an area called “triangle of death”. No significant (p < 0.05) seasonal variation was evidenced for the PM10 concentration, but in all the seasons (except for autumn) exceedances of daily concentrations (50 μg m−3) were observed. Airborne PM was analyzed for these heavy metals: Al, As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Sb, V and Zn, which represented about 8% of the PM10 concentrations. None of the metals classified by IARC as carcinogenic in humans (group 1) exceeded on average the annual EU’s and Italy’s limit. For the mentioned heavy metals the enrichment factors (EnFs) were analyzed and highlighted high enrichment for Cd, Sb, Pb, As, Cu and Zn. Principal component analysis (PCA) for the heavy metals in PM10 identified oil combustion, vehicle and industrial emissions as major sources. To assess the health risk related to the inhalation to airborne PM10 metals, we applied the Cancer Risk (CR) and Target Hazard Quotient (THQ). The results showed that the CR was similar for a child and an adult, while the THQ proved to be higher for a child than for an adult. The low PM metals risk in the urban industrial site was in agreement with the ongoing lowering trend of metals in Italy and Europe.

Published
2018

15. Chemical Composition of PM10 at Urban Sites in Naples (Italy)

Author

Elisa Perissutti, Giuseppe Onorati, Elisa Magli, Anna De Marco, Vincenzo Santagada, Ferdinando Fiorino, Francesco Barbato, Francesco Frecentese, Angela Corvino, Beatrice Cocozziello, Maria Eleonora Soggiu, Giuseppe Caliendo, Paola Di Vaio, Beatrice Severino, Irene Saccone, DI VAIO, Paola, Magli, Elisa, Barbato, Francesco, Caliendo, Giuseppe, Cocozziello, B., Corvino, Angela, DE MARCO, Anna, Fiorino, Ferdinando, Frecentese, Francesco, Onorati, G., Saccone, Irene, Santagada, Vincenzo, Soggiu, M. E., Severino, Beatrice, and Perissutti, Elisa

Subjects
Atmospheric Science, 010504 meteorology & atmospheric sciences, principal component analysis, enrichment factor, lcsh:QC851-999, 010501 environmental sciences, Environmental Science (miscellaneous), complex mixtures, 01 natural sciences, PM10, chemical composition, mass closure, otorhinolaryngologic diseases, Chemical composition, 0105 earth and related environmental sciences, Mass closure, Vegetation, Particulates, respiratory tract diseases, PM10, chemical composition, enrichment factor, mass closure, principal component analysis, Environmental chemistry, Principal component analysis, Environmental science, Gravimetric analysis, lcsh:Meteorology. Climatology, Enrichment factor
Abstract

Here, we report the chemical characterization and identification of the possible sources of particulate matter (fraction PM10) at two different sites in Naples. PM10 concentration and its chemical composition were studied using the crustal enrichment factor (EF) and principal component analysis (PCA). In all of the seasons, the PM10 levels, were significantly higher (p < 0.01) in the urban-traffic site (denominated NA02) than in the urban-background site (denominated NA01). In order to reconstruct the particle mass, the components were classified into seven classes as follows: mineral dust (MD), trace elements (TE), organic matter (OM), elemental carbon (EC), sea salt (SS), secondary inorganic aerosol (SIA) and undetermined parts (unknown (UNK)). According to the chemical mass closure obtained, the major contribution was OM, which was higher (p < 0.01) during summer than in other seasons. In both sites, a good correlation (R2 > 0.8) was obtained between reconstructed mass and gravimetric mass. PCA analysis explained 76% and 79% of the variance in NA01 and NA02, respectively. The emission sources were the same for both sites; but, the location of the site, the different distances from the sources and the presence and absence of vegetation proved the different concentrations and compositions of PM10.

Published
2016
Full Text
View/download PDF

16. Trends in H 2 S-Donors Chemistry and Their Effects in Cardiovascular Diseases.

Author

Corvino A, Frecentese F, Magli E, Perissutti E, Santagada V, Scognamiglio A, Caliendo G, Fiorino F, and Severino B

Abstract

Hydrogen sulfide (H 2 S) is an endogenous gasotransmitter recently emerged as an important regulatory mediator of numerous human cell functions in health and in disease. In fact, much evidence has suggested that hydrogen sulfide plays a significant role in many physio-pathological processes, such as inflammation, oxidation, neurophysiology, ion channels regulation, cardiovascular protection, endocrine regulation, and tumor progression. Considering the plethora of physiological effects of this gasotransmitter, the protective role of H 2 S donors in different disease models has been extensively studied. Based on the growing interest in H 2 S-releasing compounds and their importance as tools for biological and pharmacological studies, this review is an exploration of currently available H 2 S donors, classifying them by the H 2 S-releasing-triggered mechanism and highlighting those potentially useful as promising drugs in the treatment of cardiovascular diseases.

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results