1. Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
- Author
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Dai, Lu, Plunde, Oscar, Qureshi, Abdul Rashid, Lindholm, Bengt, Brismar, Torkel B., Schurgers, Leon J., Soederberg, Magnus, Ripsweden, Jonaz, Back, Magnus, Stenvinkel, Peter, Biochemie, and RS: Carim - B02 Vascular aspects thrombosis and Haemostasis
- Subjects
CHRONIC KIDNEY-DISEASE ,RISK ,end-stage renal disease ,CARDIOVASCULAR MORTALITY ,lcsh:R ,nutritional and metabolic diseases ,lcsh:Medicine ,HEMODIALYSIS-PATIENTS ,MALNUTRITION ,aortic valve calcium ,mortality ,C-REACTIVE PROTEIN ,Article ,calcification ,ATHEROSCLEROSIS ,VALVULAR CALCIFICATION ,cardiovascular diseases ,SCLEROSIS ,coronary artery calcium - Abstract
Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence of AVC and CAC, and whether AVC was associated with all-cause mortality independent of the presence of CAC in ESRD. Methods: 259 ESRD patients (median age 55 years, 67% males) undergoing cardiac computed tomography were included. Framingham risk score (FRS), presence of cardiovascular disease (CVD), statin use, nutritional status and other relevant laboratory data were determined at baseline. During follow-up for median 36 months, 44 patients died, and 68 patients underwent renal transplantation. Results: The baseline overlap presence of AVC and CAC was 37%. Multivariate regression analysis showed that FRS (odds ratio (OR) 2.25; 95% confidence interval (95% CI), 1.43−3.55) and CAC score (OR (95% CI), 2.18 (1.34−3.59)) were independent determinants of AVC. In competing-risk regression models adjusted for presence of CAC, inflammation, nutritional status, CVD, FRS and statin use, AVC remained independently associated with all-cause mortality (sub-hazard ratio (95% CI), 2.57 (1.20−5.51)). Conclusions: The overlap of AVC and CAC was 37% in this ESRD cohort. AVC was associated with increased all-cause mortality independent of presence of CAC, traditional risk factors and inflammation.
- Published
- 2020