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11 results on '"Poliseno, Mariacristina"'

1. Varicella-Zoster Virus Reactivation and Increased Vascular Risk in People Living with HIV: Data from a Retrospective Cohort Study

Author

Fiordelisi, Deborah, primary, Poliseno, Mariacristina, additional, De Gennaro, Nicolo’, additional, Milano, Eugenio, additional, Santoro, Carmen Rita, additional, Segala, Francesco Vladimiro, additional, Franco, Carlo Felice, additional, Manco Cesari, Giorgia, additional, Frallonardo, Luisa, additional, Guido, Giacomo, additional, Metrangolo, Giuliana, additional, Romita, Greta, additional, Di Gennaro, Francesco, additional, and Saracino, Annalisa, additional

Published
2023
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2. What Is the Efficacy of Sotrovimab in Reducing Disease Progression and Death in People with COVID-19 during the Omicron Era? Answers from a Real-Life Study

Author

De Vito, Andrea, primary, Colpani, Agnese, additional, Poliseno, Mariacristina, additional, Diella, Lucia, additional, Ieva, Francesco Rosario Paolo, additional, Belati, Alessandra, additional, Papale, Roberto, additional, Babudieri, Sergio, additional, De Santis, Laura, additional, Saracino, Annalisa, additional, Lo Caputo, Sergio, additional, and Madeddu, Giordano, additional

Published
2023
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4. Clinical Characteristics, Outcomes, and Risk Factors of Patients Hospitalized for COVID-19 across the Latest Pandemic Waves: Has Something Changed?

Author

Poliseno, Mariacristina, primary, Drago, Edoardo Paolo, additional, Poli, Melita Anna, additional, Altamura, Maurantonio, additional, Bruno, Serena Rita, additional, Calamo, Angela, additional, Giannelli, Anna, additional, Infante, Giovanni, additional, Mazzola, Michele, additional, Moschetta, Damiana, additional, Lo Caputo, Sergio, additional, Santantonio, Teresa Antonia, additional, and Carbonara, Sergio, additional

Published
2023
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5. Real-Life Advantages and Limits of Baricitinib for the Late Treatment of Adults Hospitalized with COVID-19

Author

Poliseno, Mariacristina, primary, Lacedonia, Donato, additional, Niglio, Mariangela, additional, De Gregorio, Federica, additional, Minafra, Graziano Antonio, additional, Campanino, Terence, additional, Giganti, Giulio, additional, Scioscia, Giulia, additional, Santantonio, Teresa Antonia, additional, Foschino Barbaro, Maria Pia, additional, and Lo Caputo, Sergio, additional

Published
2023
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7. Predictive Machine Learning Models and Survival Analysis for COVID-19 Prognosis Based on Hematochemical Parameters

Author

Altini, Nicola, primary, Brunetti, Antonio, additional, Mazzoleni, Stefano, additional, Moncelli, Fabrizio, additional, Zagaria, Ilenia, additional, Prencipe, Berardino, additional, Lorusso, Erika, additional, Buonamico, Enrico, additional, Carpagnano, Giovanna Elisiana, additional, Bavaro, Davide Fiore, additional, Poliseno, Mariacristina, additional, Saracino, Annalisa, additional, Schirinzi, Annalisa, additional, Laterza, Riccardo, additional, Di Serio, Francesca, additional, D’Introno, Alessia, additional, Pesce, Francesco, additional, and Bevilacqua, Vitoantonio, additional

Published
2021
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8. Efficacy and Safety of Remdesivir over Two Waves of the SARS-CoV-2 Pandemic

Author

Poliseno, Mariacristina, primary, Gallo, Crescenzio, additional, Cibelli, Donatella Concetta, additional, Minafra, Graziano Antonio, additional, Bottalico, Irene Francesca, additional, Bruno, Serena Rita, additional, D’Errico, Maria Luca, additional, Montemurro, Laura, additional, Rizzo, Marianna, additional, Barbera, Lucia, additional, Custodero, Giacomo Emanuele, additional, La Marca, Antonella, additional, Lo Muzio, Donatella, additional, Miucci, Anna, additional, Santantonio, Teresa Antonia, additional, and Lo Caputo, Sergio, additional

Published
2021
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10. Low-Wage Agricultural Migrant Workers in Apulian Ghettos, Italy: General Health Conditions Assessment and HIV Screening

Author

Di Gennaro, Francesco, primary, Lattanzio, Rossana, additional, Falanga, Carmine, additional, Negri, Silvia, additional, Papagni, Roberta, additional, Novara, Roberta, additional, Panico, Gianfranco Giorgio, additional, Totaro, Valentina, additional, Poliseno, Mariacristina, additional, Bavaro, Davide Fiore, additional, Raho, Lucia, additional, Schiavone, Marcella, additional, Laforgia, Nicole, additional, Volpe, Alessandro, additional, Laforgia, Renato, additional, Lo Caputo, Sergio, additional, Marotta, Claudia, additional, Putoto, Giovanni, additional, and Saracino, Annalisa, additional

Published
2021
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11. Severity of COVID-19 Patients Predicted by Serum Sphingolipids Signature

Author

Torretta, Enrica, Garziano, Micaela, Poliseno, Mariacristina, Capitanio, Daniele, Biasin, Mara, Santantonio, Teresa Antonia, Clerici, Mario, Lo Caputo, Sergio, Trabattoni, Daria, and Gelfi, Cecilia

Subjects
Adult, Male, QH301-705.5, frailty, Severity of Illness Index, Article, serine palmitoyltransferase, Young Adult, caspase 3, Humans, acid sphingomyelinase, Biology (General), QD1-999, Aged, mass spectrometry, Aged, 80 and over, sphingolipids, SARS-CoV-2, COVID-19, Middle Aged, COVID-19 severity, Prognosis, Sphingomyelins, Chemistry, Lipidomics, Female, lipids (amino acids, peptides, and proteins)
Abstract

The reason behind the high inter-individual variability in response to SARS-CoV-2 infection and patient’s outcome is poorly understood. The present study targets the sphingolipid profile of twenty-four healthy controls and fifty-nine COVID-19 patients with different disease severity. Sera were analyzed by untargeted and targeted mass spectrometry and ELISA. Results indicated a progressive increase in dihydrosphingosine, dihydroceramides, ceramides, sphingosine, and a decrease in sphingosine-1-phosphate. These changes are associated with a serine palmitoyltransferase long chain base subunit 1 (SPTLC1) increase in relation to COVID-19 severity. Severe patients showed a decrease in sphingomyelins and a high level of acid sphingomyelinase (aSMase) that influences monosialodihexosyl ganglioside (GM3) C16:0 levels. Critical patients are characterized by high levels of dihydrosphingosine and dihydroceramide but not of glycosphingolipids. In severe and critical patients, unbalanced lipid metabolism induces lipid raft remodeling, leads to cell apoptosis and immunoescape, suggesting active sphingolipid participation in viral infection. Furthermore, results indicated that the sphingolipid and glycosphingolipid metabolic rewiring promoted by aSMase and GM3 is age-dependent but also characteristic of severe and critical patients influencing prognosis and increasing viral load. AUCs calculated from ROC curves indicated ceramides C16:0, C18:0, C24:1, sphingosine and SPTLC1 as putative biomarkers of disease evolution

Published
2021

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