1. Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose
- Author
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Sea-Fue Wang, Kulandaivel Sivasankar, Rajkumar Devasenathipathy, Karuppasamy Kohila rani, and Chia Her Lin
- Subjects
Materials science ,General Chemical Engineering ,chemistry.chemical_element ,Nanoparticle ,Graphite oxide ,02 engineering and technology ,DABCO ,010402 general chemistry ,01 natural sciences ,Article ,Nanomaterials ,chemistry.chemical_compound ,General Materials Science ,glucose ,human serum samples ,Carbonization ,copper nanoparticles ,nitrogen doped graphite oxide ,metal-organic framework ,021001 nanoscience & nanotechnology ,Copper ,0104 chemical sciences ,chemistry ,Electrode ,0210 nano-technology ,Biosensor ,amperometric techniques ,Nuclear chemistry - Abstract
Copper nanoparticles with the diameter of 50 ±, 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2(BDC)2(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 &mu, M and 1803 &mu, M (linear range) with good sensitivity (2500 &mu, A mM&minus, 1 cm&minus, 2). Our glucose sensor also possesses low limits of detection (0.44 &mu, M) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose.
- Published
- 2018
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