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Your search keyword '"Ronsisvalle, Simone"' showing total 17 results
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17 results on '"Ronsisvalle, Simone"'

1. Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment

Author

Miciaccia, Morena, primary, Rizzo, Francesca, additional, Centonze, Antonella, additional, Cavallaro, Gianfranco, additional, Contino, Marialessandra, additional, Armenise, Domenico, additional, Baldelli, Olga Maria, additional, Solidoro, Roberta, additional, Ferorelli, Savina, additional, Scarcia, Pasquale, additional, Agrimi, Gennaro, additional, Zingales, Veronica, additional, Cimetta, Elisa, additional, Ronsisvalle, Simone, additional, Sipala, Federica Maria, additional, Polosa, Paola Loguercio, additional, Fortuna, Cosimo Gianluca, additional, Perrone, Maria Grazia, additional, and Scilimati, Antonio, additional

Published
2024
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2. Harmaline and Human ClpP Activation for Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) Treatment

Author

Miciaccia, Morena, primary, Rizzo, Francesca, additional, Centonze, Antonella, additional, Cavallaro, Gianfranco, additional, Contino, Marialessandra, additional, Armenise, Domenico, additional, Baldelli, Olga Maria, additional, Solidoro, Roberta, additional, Ferorelli, Savina, additional, Scarcia, Pasquale, additional, Agrimi, Gennaro, additional, Zingales, Veronica, additional, Cimetta, Elisa, additional, Ronsisvalle, Simone, additional, Sipala, Federica Maria, additional, Polosa, Paola Loguercio, additional, Fortuna, Cosimo Gianluca, additional, Perrone, Maria Grazia, additional, and Scilimati, Antonio, additional

Published
2023
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6. BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting

Author

Sorbi, Claudia, primary, Belluti, Silvia, additional, Atene, Claudio Giacinto, additional, Marocchi, Federica, additional, Linciano, Pasquale, additional, Roy, Neena, additional, Paradiso, Elia, additional, Casarini, Livio, additional, Ronsisvalle, Simone, additional, Zanocco-Marani, Tommaso, additional, Brasili, Livio, additional, Lanfrancone, Luisa, additional, Imbriano, Carol, additional, Di Rocco, Giulia, additional, and Franchini, Silvia, additional

Published
2023
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7. Different In Silico Approaches Using Heterocyclic Derivatives against the Binding between Different Lineages of SARS-CoV-2 and ACE2

Author

Sipala, Federica, primary, Cavallaro, Gianfranco, additional, Forte, Giuseppe, additional, Satriano, Cristina, additional, Giuffrida, Alessandro, additional, Fraix, Aurore, additional, Spadaro, Angelo, additional, Petralia, Salvatore, additional, Bonaccorso, Carmela, additional, Fortuna, Cosimo Gianluca, additional, and Ronsisvalle, Simone, additional

Published
2023
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9. Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells

Author

Spampinato, Mariarita, primary, Carota, Giuseppe, additional, Sferrazzo, Giuseppe, additional, Fuochi, Virginia, additional, Distefano, Alfio, additional, Ronsisvalle, Simone, additional, Sipala, Federica, additional, Giuffrida, Rosario, additional, Furneri, Pio Maria, additional, Di Rosa, Michelino, additional, Tibullo, Daniele, additional, Li Volti, Giovanni, additional, and Barbagallo, Ignazio, additional

Published
2022
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10. Orobanche crenata Forssk. Extract Affects Human Breast Cancer Cell MCF-7 Survival and Viral Replication

Author

Genovese, Carlo, primary, Garozzo, Adriana, additional, D’Angeli, Floriana, additional, Malfa, Giuseppe Antonio, additional, Bellia, Francesco, additional, Tomasello, Barbara, additional, Nicolosi, Daria, additional, Malaguarnera, Roberta, additional, Ronsisvalle, Simone, additional, Guadagni, Fiorella, additional, and Acquaviva, Rosaria, additional

Published
2022
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11. Anti-Candidal Activity of the Parasitic Plant Orobanche crenata Forssk

Author

D’Angeli, Floriana, primary, Guadagni, Fiorella, additional, Genovese, Carlo, additional, Nicolosi, Daria, additional, Trovato Salinaro, Angela, additional, Spampinato, Mariarita, additional, Mannino, Giuliana, additional, Lo Furno, Debora, additional, Petronio Petronio, Giulio, additional, Ronsisvalle, Simone, additional, Sipala, Federica, additional, Falzone, Luca, additional, and Calabrese, Vittorio, additional

Published
2021
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16. Anti-Candidal Activity of the Parasitic Plant Orobanche crenata Forssk.

Author

D'Angeli F, Guadagni F, Genovese C, Nicolosi D, Trovato Salinaro A, Spampinato M, Mannino G, Lo Furno D, Petronio Petronio G, Ronsisvalle S, Sipala F, Falzone L, and Calabrese V

Abstract

Candida albicans ( C. albicans ) and Candida glabrata ( C. glabrata ) are part of the human microbiome. However, they possess numerous virulence factors, which confer them the ability to cause both local and systemic infections. Candidiasis can involve multiple organs, including the eye. In the present study, we investigated the anti-candidal activity and the re-epithelizing effect of Orobanche crenata leaf extract (OCLE). By the microdilution method, we demonstrated an inhibitory effect of OCLE on both C. albicans and C. glabrata growth. By crystal violet and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, we showed the ability of OCLE to inhibit the biofilm formation and the viability of yeast cells, respectively. By germ tube and adhesion assays, we proved the capacity of OCLE to affect the morphological transition of C. albicans and the adhesion of both pathogens to human retinal pigment epithelial cells (ARPE-19), respectively. Besides, by MTT and wound healing assay, we evaluated the cytotoxic and re-epithelizing effects of OCLE on ARPE-19. Finally, the Folin-Ciocalteu and the ultra-performance liquid chromatography-tandem mass spectrometry revealed a high content of phenols and the presence of several bioactive molecules in the extract. Our results highlighted new properties of O. crenata , useful in the control of Candida infections.

Published
2021
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17. Antimicrobial, Antioxidant, and Cytotoxic Activities of Juglans regia L. Pellicle Extract.

Author

D'Angeli F, Malfa GA, Garozzo A, Li Volti G, Genovese C, Stivala A, Nicolosi D, Attanasio F, Bellia F, Ronsisvalle S, and Acquaviva R

Abstract

The difficulty to treat resistant strains-related hospital-acquired infections (HAIs) promoted the study of phytoextracts, known sources of bioactive molecules. Accordingly, in the present study, the pharmacological activities of Juglans regia (L.) pellicle extract (WPE) were investigated. The antiviral effect was tested against Herpes simplex virus type 1 and 2, Poliovirus 1, Adenovirus 2, Echovirus 9, Coxsackievirus B1 through the plaque reduction assay. The antibacterial and antifungal activities were evaluated against medically important strains, by the microdilution method. DPPH and superoxide dismutase (SOD)s-like activity assays were used to determine the antioxidant effect. Besides, the extract was screened for cytotoxicity on Caco-2, MCF-7, and HFF1 cell lines by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay. The total phenolic and flavonoid contents were also evaluated. Interestingly, WPE inhibited Herpes simplex viruses (HSVs) replication, bacterial and fungal growth. WPE showed free radical scavenging capacity and inhibited superoxide anion formation in a dose-dependent manner. These effects could be attributed to the high content of phenols and flavonoids, which were 0.377 ± 0.01 mg GE/g and 0.292 ± 0.08 mg CE/g, respectively. Moreover, WPE was able to reduce Caco-2 cell viability, at both 48 h and 72 h. The promising results encourage further studies aimed to better elucidate the role of WPE in the prevention of human infectious diseases.

Published
2021
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