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16 results on '"Sechi, Illari"'

4. A Whole-Genome Sequencing-Based Approach for the Characterization of Klebsiella pneumoniae Co-Producing KPC and OXA-48-like Carbapenemases Circulating in Sardinia, Italy

Author

Del Rio, Arcadia, primary, Fox, Valeria, additional, Muresu, Narcisa, additional, Sechi, Illari, additional, Cossu, Andrea, additional, Palmieri, Alessandra, additional, Scutari, Rossana, additional, Alteri, Claudia, additional, Sotgiu, Giovanni, additional, Castiglia, Paolo, additional, and Piana, Andrea, additional

Published
2023
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5. Preliminary Results of Feasibility and Acceptability of Self-Collection for Cervical Screening in Italian Women

Author

Sechi, Illari, primary, Muresu, Narcisa, additional, Puci, Mariangela V., additional, Saderi, Laura, additional, Del Rio, Arcadia, additional, Cossu, Andrea, additional, Muroni, Maria R., additional, Castriciano, Santina, additional, Martinelli, Marianna, additional, Cocuzza, Clementina E., additional, Sotgiu, Giovanni, additional, and Piana, Andrea, additional

Published
2023
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7. Evaluation of BD Onclarity™ HPV Assay on Self-Collected Vaginal and First-Void Urine Samples as Compared to Clinician-Collected Cervical Samples: A Pilot Study

Author

Martinelli, Marianna, primary, Giubbi, Chiara, additional, Sechi, Illari, additional, Bottari, Fabio, additional, Iacobone, Anna Daniela, additional, Musumeci, Rosario, additional, Perdoni, Federica, additional, Muresu, Narcisa, additional, Piana, Andrea, additional, Fruscio, Robert, additional, Landoni, Fabio, additional, and Cocuzza, Clementina Elvezia, additional

Published
2022
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10. Comparison of Different Self-Sampling Devices for Molecular Detection of Human Papillomavirus (HPV) and Other Sexually Transmitted Infections (STIs): A Pilot Study

Author

Sechi, I, Cocuzza, C, Martinelli, M, Muresu, N, Castriciano, S, Sotgiu, G, Piana, A, Sechi, Illari, Elvezia, Cocuzza Clementina, Martinelli, Marianna, Muresu, Narcisa, Castriciano, Santina, Sotgiu, Giovanni, Piana, Andrea, Sechi, I, Cocuzza, C, Martinelli, M, Muresu, N, Castriciano, S, Sotgiu, G, Piana, A, Sechi, Illari, Elvezia, Cocuzza Clementina, Martinelli, Marianna, Muresu, Narcisa, Castriciano, Santina, Sotgiu, Giovanni, and Piana, Andrea

Abstract

Background: Cervical cancer is the fourth most common cancer in women, and it is well known that high-risk human papillomavirus (hrHPV) infections are the necessary carcinogenic factors for the development of cervical tumors. Moreover, the interaction between HPV and other sexually transmitted infections (STIs) may increase the risk of cancer progression. Self-sampling has been demonstrated to represent a valid and well-accepted alternative, favoring women’s participation in screening programs. This study aimed to investigate the use of FLOQSwabs® (FS) as compared to two other vaginal self-collection devices for the detection of hrHPV and other sexually transmitted infections. Methods: Cervical and vaginal self-samples were collected, using two different combinations of vaginal self-sampling devices, from 40 women referred to colposcopy for a documented abnormal Pap smear. All samples were tested for hrHPV and seven STI pathogens using two commercial molecular assays. Results: Data on hrHPV detection from the first group of women showed an almost perfect agreement (kappa: 0.89) between cervical vs. FS vaginal self-samples, and a substantial agreement (kappa: 0.79) between cervical and HerSwabTM (HS) samples. In the second group of women, an almost perfect agreement (kappa: 0.90) was demonstrated in the detection of hrHPV between cervical samples vs. FS, and a moderate agreement (kappa: 0.60) for cervical vs. Evalyn® Brush (EB) self-collected samples. STI detections showed a very good agreement (kappa: 0.89 and kappa: 1.00) both among FS vs. HS and FS vs. EB, respectively. There was no statistically significant difference between the different devices used. The most frequently detected hrHPV geno-types in the studied population were HPV 16, 31, 35, 51, and 56; whilst the most frequently identified STI pathogens were Ureaplasma parvum and Mycoplasma hominis. Overall, investigated women did not report any discomfort in using the different vaginal self-collection device

Published
2022

12. High-Risk Clone of Klebsiella pneumoniae Co-Harbouring Class A and D Carbapenemases in Italy

Author

Del Rio, Arcadia, primary, Muresu, Narcisa, additional, Sotgiu, Giovanni, additional, Saderi, Laura, additional, Sechi, Illari, additional, Cossu, Andrea, additional, Usai, Manuela, additional, Palmieri, Alessandra, additional, Are, Bianca Maria, additional, Deiana, Giovanna, additional, Cocuzza, Clementina, additional, Martinelli, Marianna, additional, Calaresu, Enrico, additional, and Piana, Andrea Fausto, additional

Published
2022
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13. Cervical Screening in North Sardinia (Italy): Genotype Distribution and Prevalence of HPV among Women with ASC-US Cytology

Author

Muresu, Narcisa, primary, Sotgiu, Giovanni, additional, Marras, Silvia, additional, Gentili, Davide, additional, Sechi, Illari, additional, Cossu, Andrea, additional, Dettori, Arianna, additional, Pietri, Roberto Enrico, additional, Paoni, Luisa, additional, Ghi, Maria Eugenia, additional, Bagella, Maria Paola, additional, Marrazzu, Adriano, additional, Cossu, Antonio, additional, Genovesi, Antonio, additional, Piana, Andrea, additional, and Saderi, Laura, additional

Published
2022
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16. Diagnostic Performance of Host and Viral DNA Methylation Analysis in the Identification of Anal Intraepithelial Neoplasia and Cancer: Systematic Review and Meta-Analysis.

Author

Muresu N, Puci MV, Sotgiu G, Sechi I, Cossu A, Usai M, and Piana AF

Abstract

Introduction: DNA methylation-based biomarkers have been investigated as useful tools in the carcinogenesis process, including the triage of HPV-associated cancers. In this context, we conducted a systematic review and meta-analysis focused on evaluating the changes in the level of DNA methylation in cases of pre-cancerous (i.e., anal intraepithelial neoplasia, AIN-1, -2., -3) and cancerous (i.e., squamous cell carcinoma, SCC) anal lesions., Methods: A research in the PubMed, Scopus, and Web of Science databases was carried out, following the PRISMA 2020 protocol, using the following keywords: "anal cancer", "anal intraepithelial neoplasia", "methylation", and "epigenetic". All observational studies that reported the level of DNA methylation by grade of anal lesions and for different target genes were included. The QUADAS-2 tool was used to assess the studies' quality, whereas pooled prevalence, sensitivity, specificity, and diagnostic odds ratio (DOR) were employed to verify the accuracy of the test in the detection of high-grade lesions., Results: Eight studies met the inclusion criteria, involving a total of 1555 clinical samples. The prevalence of methylation-positive samples by histological grading was 27%, 45%, 54%, and 98% for AIN1, AIN2, AIN3, and SCC, respectively. Similar results were observed for the DOR, with higher ORs in more severe lesions. The pooled AUC (95%CI) for the diagnosis of ≥AIN2 was 0.68 (0.63-0.73)., Conclusions: The present review and meta-analysis support the introduction of DNA methylation-based biomarkers in the triage of subjects with low-grade anal lesions and in the monitoring of treatment outcomes. Standardized protocols and a prospective study design are needed to implement methylation tests in clinical practice.

Published
2024
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