1. Oxidative Stress in Complex Regional Pain Syndrome (CRPS): No Systemically Elevated Levels of Malondialdehyde, F2-Isoprostanes and 8OHdG in a Selected Sample of Patients
- Author
-
Jan Nouta, Wouter W.A. Zuurmond, Sigrid G. L. Fischer, Roberto S.G.M. Perez, Peter G. Scheffer, Anesthesiology, Clinical chemistry, EMGO - Musculoskeletal health, ICaR - Circulation and metabolism, and CCA - Innovative therapy
- Subjects
MDA ,CRPS ,Urine ,medicine.disease_cause ,F2-isoprostanes ,Gastroenterology ,lcsh:Chemistry ,Pathogenesis ,Lipid peroxidation ,chemistry.chemical_compound ,Malondialdehyde ,oxidative stress ,Child ,lcsh:QH301-705.5 ,Spectroscopy ,General Medicine ,Middle Aged ,Computer Science Applications ,Complex regional pain syndrome ,8-Hydroxy-2'-Deoxyguanosine ,Child, Preschool ,Female ,Adult ,medicine.medical_specialty ,Age and sex ,Article ,Catalysis ,Inorganic Chemistry ,Internal medicine ,medicine ,Humans ,Physical and Theoretical Chemistry ,Molecular Biology ,Aged ,8OHdG ,business.industry ,Organic Chemistry ,Deoxyguanosine ,Infant ,medicine.disease ,Surgery ,Reflex Sympathetic Dystrophy ,F2-Isoprostanes ,lcsh:Biology (General) ,lcsh:QD1-999 ,chemistry ,inflammation ,Lipid Peroxidation ,business ,Biomarkers ,Oxidative stress ,DNA Damage - Abstract
Exaggerated inflammation and oxidative stress are involved in the pathogenesis of Complex Regional Pain Syndrome (CRPS). However, studies assessing markers for oxidative stress in CRPS patients are limited. In this study, markers for lipid peroxidation (malondialdehyde and F2-isoprostanes) and DNA damage (8-hydroxy-2-deoxyguanosine) were measured in nine patients (mean age 50.1 ± 17.1 years) with short term CRPS-1 (median 3 months) and nine age and sex matched healthy volunteers (mean age 49.3 ± 16.8 years) to assess and compare the level of oxidative stress. No differences were found in plasma between CRPS patients and healthy volunteers for malondialdehyde (5.2 ± 0.9 µmol/L vs. 5.4 ± 0.5 µmol/L) F2-isoprostanes (83.9 ± 18.7 pg/mL vs. 80.5 ± 12.3 pg/mL) and 8-hydroxy-2-deoxyguanosine (92.6 ± 25.5 pmol/L vs. 86.9 ± 19.0 pmol/L). Likewise, in urine, no differences were observed between CRPS patients and healthy volunteers for F2-isoprostanes (117 ng/mmol, IQR 54.5-124.3 vs. 85 ng/mmol, IQR 55.5-110) and 8-hydroxy-2-deoxyguanosine (1.4 ± 0.7 nmol/mmol vs. 1.4 ± 0.5 nmol/mmol). Our data show no elevation of systemic markers of oxidative stress in CRPS patients compared to matched healthy volunteers. Future research should focus on local sampling methods of oxidative stress with adequate patient selection based on CRPS phenotype and lifestyle.
- Published
- 2013
- Full Text
- View/download PDF