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Your search keyword '"Sugimura, Yukiharu"' showing total 7 results
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7 results on '"Sugimura, Yukiharu"'

1. Three-Dimensional Bioprinting of Ovine Aortic Valve Endothelial and Interstitial Cells for the Development of Multicellular Tissue Engineered Tissue Constructs

Author

Immohr, Moritz Benjamin, primary, Teichert, Helena Lauren, additional, dos Santos Adrego, Fabió, additional, Schmidt, Vera, additional, Sugimura, Yukiharu, additional, Bauer, Sebastian Johannes, additional, Barth, Mareike, additional, Lichtenberg, Artur, additional, and Akhyari, Payam, additional more...

Published
2023
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2. Optimizing Anastomoses Technique in Orthotopic Heart Transplantation: Comparison of Biatrial, Bicaval and Modified Bicaval Technique

Author

Immohr, Moritz Benjamin, primary, Boeken, Udo, additional, Bruno, Raphael Romano, additional, Sugimura, Yukiharu, additional, Mehdiani, Arash, additional, Aubin, Hug, additional, Westenfeld, Ralf, additional, Tudorache, Igor, additional, Lichtenberg, Artur, additional, and Akhyari, Payam, additional more...

Published
2022
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4. Altered mRNA Expression of Interleukin-1 Receptors in Myocardial Tissue of Patients with Left Ventricular Assist Device Support

Author

Niazy, Naima, primary, Mrozek, Linus, additional, Barth, Mareike, additional, Immohr, Moritz Benjamin, additional, Kalampokas, Nikolaos, additional, Saeed, Diyar, additional, Aubin, Hug, additional, Sugimura, Yukiharu, additional, Westenfeld, Ralf, additional, Boeken, Udo, additional, Lichtenberg, Artur, additional, and Akhyari, Payam, additional more...

Published
2021
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7. The Focal Induction of Reactive Oxygen Species in Rats as a Trigger of Aortic Valve Degeneration.

Author

Selig JI, Sugimura Y, Katahira S, Polidori M, Jacobi LA, Medovoj O, Betke S, Barth M, Lichtenberg A, Akhyari P, and Minol JP

Abstract

Background: Degenerative aortic valve disease (DAVD) is a multifactorial process. We developed an animal model to analyze the isolated, local effect of reactive oxygen species (ROS) on its pathophysiology., Methods: We utilized a photodynamic reaction (PDR) as a source of ROS in the aortic valve by aiming a laser at the aortic valve for 60 min after the administration of a photosensitizer 24 h prior. ROS, laser, and sham groups ( n = 7 each) for every observation period (t = 0; t = 8 d; t = 84 d; t = 168 d) were established. The amount of ROS generation; morphological changes; inflammatory, immune, and apoptotic reactions; and hemodynamic changes in the aortic valves were assessed using appropriate histological, immunohistological, immunohistochemical, and echocardiographic methods., Results: The ROS group displayed an increased amount of ROS ( p < 0.01) and increased inflammatory activation of the endothelium ( p < 0.05) at t = 0. In the ROS group, aortic valves were calcified ( p < 0.05) and the transvalvular gradient was increased ( p < 0.01) at t = 168 d., Conclusion: The small animal model employed here may serve as a platform for analyzing ROS's isolated role in the DAVD context. more...

Published
2024
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