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10 results on '"Tomasetti, Carmine"'

4. Gut Microbiota and Bipolar Disorder: An Overview on a Novel Biomarker for Diagnosis and Treatment

Author

Lucidi, Lorenza, primary, Pettorruso, Mauro, additional, Vellante, Federica, additional, Di Carlo, Francesco, additional, Ceci, Franca, additional, Santovito, Maria Chiara, additional, Di Muzio, Ilenia, additional, Fornaro, Michele, additional, Ventriglio, Antonio, additional, Tomasetti, Carmine, additional, Valchera, Alessandro, additional, Gentile, Alessandro, additional, Kim, Yong-Ku, additional, Martinotti, Giovanni, additional, Fraticelli, Silvia, additional, Di Giannantonio, Massimo, additional, and De Berardis, Domenico, additional

Published
2021
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5. Eradicating Suicide at Its Roots: Preclinical Bases and Clinical Evidence of the Efficacy of Ketamine in the Treatment of Suicidal Behaviors

Author

De Berardis, Domenico, primary, Fornaro, Michele, additional, Valchera, Alessandro, additional, Cavuto, Marilde, additional, Perna, Giampaolo, additional, Di Nicola, Marco, additional, Serafini, Gianluca, additional, Carano, Alessandro, additional, Pompili, Maurizio, additional, Vellante, Federica, additional, Orsolini, Laura, additional, Fiengo, Annastasia, additional, Ventriglio, Antonio, additional, Yong-Ku, Kim, additional, Martinotti, Giovanni, additional, Di Giannantonio, Massimo, additional, and Tomasetti, Carmine, additional

Published
2018
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6. The Role of Inhaled Loxapine in the Treatment of Acute Agitation in Patients with Psychiatric Disorders: A Clinical Review

Author

de Berardis, Domenico, primary, Fornaro, Michele, additional, Orsolini, Laura, additional, Iasevoli, Felice, additional, Tomasetti, Carmine, additional, de Bartolomeis, Andrea, additional, Serroni, Nicola, additional, Valchera, Alessandro, additional, Carano, Alessandro, additional, Vellante, Federica, additional, Marini, Stefano, additional, Piersanti, Monica, additional, Perna, Giampaolo, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional

Published
2017
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7. Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions

Author

Tomasetti, Carmine, primary, Iasevoli, Felice, additional, Buonaguro, Elisabetta, additional, De Berardis, Domenico, additional, Fornaro, Michele, additional, Fiengo, Annastasia, additional, Martinotti, Giovanni, additional, Orsolini, Laura, additional, Valchera, Alessandro, additional, Di Giannantonio, Massimo, additional, and de Bartolomeis, Andrea, additional

Published
2017
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8. Agomelatine beyond Borders: Current Evidences of Its Efficacy in Disorders Other than Major Depression

Author

De Berardis, Domenico, primary, Fornaro, Michele, additional, Serroni, Nicola, additional, Campanella, Daniela, additional, Rapini, Gabriella, additional, Olivieri, Luigi, additional, Srinivasan, Venkataramanujam, additional, Iasevoli, Felice, additional, Tomasetti, Carmine, additional, De Bartolomeis, Andrea, additional, Valchera, Alessandro, additional, Perna, Giampaolo, additional, Mazza, Monica, additional, Di Nicola, Marco, additional, Martinotti, Giovanni, additional, and Di Giannantonio, Massimo, additional

Published
2015
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9. The Melatonergic System in Mood and Anxiety Disorders and the Role of Agomelatine: Implications for Clinical Practice

Author

De Berardis, Domenico, primary, Marini, Stefano, additional, Fornaro, Michele, additional, Srinivasan, Venkataramanujam, additional, Iasevoli, Felice, additional, Tomasetti, Carmine, additional, Valchera, Alessandro, additional, Perna, Giampaolo, additional, Quera-Salva, Maria-Antonia, additional, Martinotti, Giovanni, additional, and di Giannantonio, Massimo, additional

Published
2013
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10. Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions

Author

Michele Fornaro, Felice Iasevoli, Andrea de Bartolomeis, Giovanni Martinotti, Carmine Tomasetti, Massimo Di Giannantonio, Elisabetta F. Buonaguro, Domenico De Berardis, Laura Orsolini, Annastasia L.C. Fiengo, Alessandro Valchera, Tomasetti, Carmine, Iasevoli, Felice, Buonaguro, ELISABETTA FILOMENA, De Berardis, Domenico, Fornaro, Michele, Fiengo, ANNASTASIA LUCIA CARMELA, Martinotti, Giovanni, Orsolini, Laura, Valchera, Alessandro, Di Giannantonio, Massimo, and DE BARTOLOMEIS, Andrea

Subjects
0301 basic medicine, medicine.medical_specialty, Dopamine, Glutamic Acid, Review, Neurotransmission, Biology, Models, Biological, Catalysis, transductional pathways, Inorganic Chemistry, Synapse, lcsh:Chemistry, 03 medical and health sciences, Glutamatergic, 0302 clinical medicine, Postsynaptic potential, medicine, Animals, Humans, Physical and Theoretical Chemistry, Psychiatry, Molecular Biology, lcsh:QH301-705.5, Spectroscopy, postsynaptic density (PSD), bipolar disorder, Organic Chemistry, Glutamate receptor, Intracellular Signaling Peptides and Proteins, Post-Synaptic Density, General Medicine, Computer Science Applications, schizophrenia, 030104 developmental biology, Homer, Psychotic Disorders, lcsh:Biology (General), lcsh:QD1-999, Excitatory postsynaptic potential, gene expression, Postsynaptic density, 030217 neurology & neurosurgery, medicine.drug, Antipsychotic Agents, Signal Transduction
Abstract

Dopamine-glutamate interplay dysfunctions have been suggested as pathophysiological key determinants of major psychotic disorders, above all schizophrenia and mood disorders. For the most part, synaptic interactions between dopamine and glutamate signaling pathways take part in the postsynaptic density, a specialized ultrastructure localized under the membrane of glutamatergic excitatory synapses. Multiple proteins, with the role of adaptors, regulators, effectors, and scaffolds compose the postsynaptic density network. They form structural and functional crossroads where multiple signals, starting at membrane receptors, are received, elaborated, integrated, and routed to appropriate nuclear targets. Moreover, transductional pathways belonging to different receptors may be functionally interconnected through postsynaptic density molecules. Several studies have demonstrated that psychopharmacologic drugs may differentially affect the expression and function of postsynaptic genes and proteins, depending upon the peculiar receptor profile of each compound. Thus, through postsynaptic network modulation, these drugs may induce dopamine-glutamate synaptic remodeling, which is at the basis of their long-term physiologic effects. In this review, we will discuss the role of postsynaptic proteins in dopamine-glutamate signals integration, as well as the peculiar impact of different psychotropic drugs used in clinical practice on postsynaptic remodeling, thereby trying to point out the possible future molecular targets of "synapse-based" psychiatric therapeutic strategies.

Published
2017

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