1. Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution
- Author
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Charles H. Malbert, Seva Hatzinikolas, Kylie Lange, Hung Pham, Christine Feinle-Bisset, Ryan Jalleh, Laurence G. Trahair, Karen L. Jones, Michael Horowitz, Madeline Buttfield, Chinmay S. Marathe, Tongzhi Wu, Rachael S. Rigda, Christopher K. Rayner, Jalleh, Ryan, Pham, Hung, Marathe, Chinmay S, Wu, Tongzhi, Buttfield, Madeline D, Hatzinikolas, Seva, Malbert, Charles H, Rigda, Rachael S, Lange, Kylie, Trahair, Laurence G, Feinle-bisset, Christine, Rayner, Christopher K, Horowitz, Michael, Jones, Karen L, Royal Adelaide Hospital, Adelaide Medical School [Australia], University of Adelaide, University of South Australia [Adelaide], US 1395 ANI-SCAN [INRA], and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
- Subjects
Male ,Type 2 diabetes ,030204 cardiovascular system & hematology ,Gastroenterology ,Placebos ,chemistry.chemical_compound ,0302 clinical medicine ,Weight loss ,Medicine ,intragastric meal retention ,Meals ,Meal ,Cross-Over Studies ,Nutrition and Dietetics ,Stomach ,Middle Aged ,3. Good health ,medicine.anatomical_structure ,Female ,type 2 diabetes ,medicine.symptom ,lcsh:Nutrition. Foods and food supply ,lixisenatide ,medicine.medical_specialty ,lcsh:TX341-641 ,030209 endocrinology & metabolism ,Placebo ,Glucagon-Like Peptide-1 Receptor ,Article ,Beverages ,03 medical and health sciences ,Lixisenatide ,Double-Blind Method ,Internal medicine ,Humans ,Hypoglycemic Agents ,Aged ,Gastric emptying ,business.industry ,medicine.disease ,Crossover study ,Glucose ,Diabetes Mellitus, Type 2 ,Gastric Emptying ,chemistry ,energy intake ,Peptides ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition ,Food Science - Abstract
Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (p <, 0.001) and distal (p <, 0.001) stomach and decreased EI (p <, 0.001). EI was not related to the content of the total or proximal stomach but inversely related to the distal stomach at 180 min in health on placebo (r = &minus, 0.58, p = 0.03) but not in T2D nor after lixisenatide in either group. In healthy and T2D participants, the reduction in EI by lixisenatide is unrelated to changes in GE/intragastric distribution, consistent with a centrally mediated effect.
- Published
- 2020