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5 results on '"Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)"'

1. Effects of Aircraft Noise Exposure on Heart Rate during Sleep in the Population Living Near Airports

Author

Maxime Elbaz, Matthieu Sineau, Bernard Laumon, Carlos Ribeiro, Anne-Sophie Evrard, Fanny Mietlicki, Marie Lefevre, Philippe Nguyen, Damien Leger, Ali Mohamed Nassur, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM - EA 7330), Institut de Recherche Biomédicale des Armées (IRBA)-Université Paris Descartes - Paris 5 (UPD5), Bruitparif, Département Transport, Santé, Sécurité (IFSTTAR/TS2), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université de Lyon, Université Paris Descartes - Paris 5 (UPD5)-Institut de Recherche Biomédicale des Armées (IRBA), and Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)

Subjects
Male, Aircraft, Aircraft noise, Health, Toxicology and Mutagenesis, lcsh:Medicine, 030204 cardiovascular system & hematology, 010501 environmental sciences, Audiology, 01 natural sciences, 0302 clinical medicine, SANTE, Sound pressure, education.field_of_study, HEART RATE, Middle Aged, 3. Good health, BRUIT, Noise, Transportation, Female, Sleep (system call), Adult, AVION, Paris, medicine.medical_specialty, Adolescent, Airports, Population, Article, Background noise, Young Adult, 03 medical and health sciences, CROSS-SECTIONAL STUDY, parasitic diseases, Heart rate, medicine, Humans, Sleep Hygiene, education, Aged, 0105 earth and related environmental sciences, Noise pollution, lcsh:R, Urban Health, Public Health, Environmental and Occupational Health, AIRCRAFT NOISE, Environmental Exposure, SLEEP, Noise, Environmental science, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, human activities
Abstract

Background Noise in the vicinity of airports is a public health problem. Many laboratory studies have shown that heart rate is altered during sleep after exposure to road or railway noise. Fewer studies have looked at the effects of exposure to aircraft noise on heart rate during sleep in populations living near airports. Objective The aim of this study was to investigate the relationship between the sound pressure level (SPL) of aircraft noise and heart rate during sleep in populations living near airports in France. Methods In total, 92 people living near the Paris-Charles de Gaulle and Toulouse-Blagnac airports participated in this study. Heart rate was recorded every 15 s during one night, using an Actiheart monitor, with simultaneous measurements of SPL of aircraft noise inside the participants&rsquo, bedrooms. Energy and event-related indicators were then estimated. Mixed linear regression models were applied, taking into account potential confounding factors, to investigate the relationship between energy indicators and heart rate during sleep measured every 15 s. Event-related analyses were also carried out in order to study the effects of an acoustic event associated with aircraft noise on heart rate during sleep. Results The more the SPL from all sources (LAeq,15s) and the SPL exceeded for 90% of the measurement period (LA90,15s) increased, the more heart rate also increased. No significant associations were observed between the maximum 1-s equivalent SPL associated with aircraft overflight (LAmax,1s) and differences between the heart rate recorded during or 15 or 30 s after an aircraft noise event and that recorded before the event. On the other hand, a positive and significant association was found between LAmax,1s and the heart rate amplitude calculated during an aircraft noise event. Results were unchanged when analyses were limited to participants who had lived more than five years in their present dwelling. Conclusion Our study shows that exposure to the maximum SPL linked to aircraft overflight affect the heart rate during sleep of residents near airports. However, further studies on a larger number of participants over several nights are needed to confirm these results.

Published
2019

2. Seasonal Variations and Chemical Predictors of Oxidative Potential (OP) of Particulate Matter (PM), for Seven Urban French Sites

Author

Boualem Mesbah, Florie Chevrier, Aurélie Charron, Alexandre Albinet, Samuël Weber, Jean M.F. Martins, Guillaume Brulfert, Gaëlle Uzu, Aude Calas, Matteo Redaelli, Jean-Luc Besombes, Jean-Luc Jaffrezo, Olivier Favez, Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire de Chimie Moléculaire et Environnement (LCME), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry]), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), Département Aménagement, Mobilités et Environnement (IFSTTAR/AME), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université de Lyon-PRES Université Nantes Angers Le Mans (UNAM)-Communauté Université Paris-Est, Institut National de l'Environnement Industriel et des Risques (INERIS), Atmo Nouvelle-Aquitaine, ATMO Auvergne-Rhône-Alpes (ATMO-AURA), UMR 5001, Institut des Géosciences de l’Environnement, Université Grenoble Alpes (UGA), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Université Grenoble Alpes (UGA), Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] (LEGI), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Atmo-Sud, GeographR, Laboratoire de glaciologie et géophysique de l'environnement (LGGE), Observatoire des Sciences de l'Univers de Grenoble (OSUG), Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre National de la Recherche Scientifique (CNRS), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut de Recherche pour le Développement (IRD)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Direction de l'Evaluation des Risques (DER), IFSTTAR, Laboratoire Transports et Environnement (IFSTTAR/AME/LTE), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-Université de Lyon, LCSQA - Laboratoire Central de Surveillance de la Qualité de l’Air, Laboratoire des Écoulements Géophysiques et Industriels [Grenoble] (LEGI ), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), This work was partially funded by ANSES for OP measurements (ExPOSURE program, grant 2016-CRD-31), IDEX UGA grant for innovation 2017 ROS-ONLINE, Atmo Sud for the chemical analyses of the samples from Nice and Port-de-Bouc, and the French Ministry of Environment, as part of the National reference laboratory for air quality (LCSQA), for the samples from Grenoble, Talence and Nice. The study in Chamonix was funded by ADEME. The University of Grenoble Alpes funded the PhD grant of A. Calas with a 'President Award'. The PhD of Samuël Weber was funded by a grant from ENS Paris. The PhD of Florie Chevrier was funded by Région Rhône-Alpes Auvergne. This study was also supported by direct funding by IGE (technician salary), the LEFE CHAT (program 863353: 'Le PO comme proxy de l’impact sanitaire'), and LABEX OSUG@2020 (ANR-10-LABX-56) (both for funding analytical instruments)., Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology [2007-2019] (Grenoble INP [2007-2019])-Institut de Recherche pour le Développement (IRD)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Institut de Recherche pour le Développement (IRD)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), and ANR-10-LABX-0056,OSUG@2020,Innovative strategies for observing and modelling natural systems(2010)

Subjects
Atmospheric Science, 010504 meteorology & atmospheric sciences, Air pollution, 010501 environmental sciences, Environmental Science (miscellaneous), lcsh:QC851-999, medicine.disease_cause, GEOF, 01 natural sciences, Road transport, Urban background, 11. Sustainability, medicine, [CHIM]Chemical Sciences, OP tracerspredictors, chemical composition of PM, Biomass burning, chemical composition of pm, op tracers/predictors, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences, oxidative potential, Particulates, urban background sites, MESH: Particulate Matter, [SDU]Sciences of the Universe [physics], 13. Climate action, Environmental chemistry, [SDE]Environmental Sciences, Atmospheric pollutants, Environmental science, lcsh:Meteorology. Climatology
Abstract

Epidemiological studies suggest that the main part of chronic effects from air pollution is likely to be linked with particulate matter (PM). Oxidative potential (OP) of PM is gaining strong interest as a promising health exposure metric. This study combined atmospheric detailed composition results obtained for seven different urban background environments over France to examine any possible common feature in OP seasonal variations obtained using two assays (acid ascorbic (AA) and dithiothreitol (DTT)) along a large set of samples ( N &gt, 700 ). A remarkable homogeneity in annual cycles was observed with a higher OP activity in wintertime at all investigated sites. Univariate correlations were used to link the concentrations of some major chemical components of PM and their OP. Four PM components were identified as OP predictors: OC, EC, monosaccharides and Cu. These species are notably emitted by road transport and biomass burning, targeting main sources probably responsible for the measured OP activity. The results obtained confirm that the relationship between OP and atmospheric pollutants is assay- and location-dependent and, thus, the strong need for a standardized test, or set of tests, for further regulation purposes.

Published
2019

3. Integrative System Biology Analyses Identify Seven MicroRNAs to Predict Heart Failure

Author

Henri Charrier, Paul Mulder, Emilie Dubois-Deruy, Florence Pinet, Marie Cuvelliez, Vincent Richard, Christophe Bauters, Pinet, Florence, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Nouvelles Cibles Pharmacologiques de la Protection Endothéliale et de l'Insuffisance Cardiaque (EnVI), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biomécanique et Mécanique des Chocs (LBMC UMR T9406), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Epidémiologie des maladies chroniques: impact des intéractions gène environnement sur la santé des populations, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, and Normandie Université (NU)

Subjects
0301 basic medicine, Mirna signature, lcsh:QH426-470, In silico, Systems biology, heart failure, Computational biology, 030204 cardiovascular system & hematology, Biology, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, microRNA, Genetics, medicine, Myocardial infarction, Ventricular remodeling, Molecular Biology, business.industry, system biology, biomarkers, medicine.disease, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, 3. Good health, Clinical Practice, lcsh:Genetics, 030104 developmental biology, cardiology, Heart failure, miRNAs, business
Abstract

International audience; Heart failure (HF) has several etiologies including myocardial infarction (MI) and left 24 ventricular remodeling (LVR), but its progression remains difficult to predict in clinical practice. 25 Systems biology analyses of LVR after MI predict molecular insights of this event such as 26 modulation of microRNA (miRNA) that could be used as a signature of HF progression. To define 27 a miRNA signature of LVR after MI, we use 2 systems biology approaches integrating either 28 proteomic data generated from LV of post-MI rat induced by left coronary artery ligation or 29 multi-omics data (proteins and non-coding RNAs) generated from plasma of post-MI patients from 30 the REVE-2 study. The first approach predicts 13 miRNAs and 3 of these miRNAs were validated 31 to be associated with LVR in vivo: miR-21-5p, miR-23a-3p and miR-222-3p. The second approach 32 predicts 24 miRNAs among 1310 molecules and 6 of these miRNAs were selected to be associated 33 with LVR in silico: miR-17-5p, miR-21-5p, miR-26b-5p, miR-222-3p, miR-335-5p and miR-375. We 34 identified a signature of 7 microRNAs associated with LVR after MI that support the interest of 35 integrative systems biology analyses to define a miRNA signature of HF progression. 36

Published
2019

4. Dynamic Wireless Power Transfer Charging Infrastructure for Future EVs: From Experimental Track to Real Circulated Roads Demonstrations

Author

Virginie Deniau, Alexandre De Bernardinis, Nicolas Hautiere, Gérard Coquery, Stéphane Laporte, VEhicule DEcarboné et COmmuniquant et sa Mobilité (VeDeCom), Laboratoire Électronique Ondes et Signaux pour les Transports (IFSTTAR/COSYS/LEOST), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-PRES Université Lille Nord de France, Technologies pour une Electro-Mobilité Avancée (SATIE-TEMA), Composants et Systèmes pour l'Energie Electrique (CSEE), Systèmes et Applications des Technologies de l'Information et de l'Energie (SATIE), École normale supérieure - Cachan (ENS Cachan)-Université Paris-Sud - Paris 11 (UP11)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-École normale supérieure - Rennes (ENS Rennes)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Cachan (ENS Cachan)-Université Paris-Sud - Paris 11 (UP11)-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)-École normale supérieure - Rennes (ENS Rennes)-Université de Cergy Pontoise (UCP), Université Paris-Seine-Université Paris-Seine-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre National de la Recherche Scientifique (CNRS)-Systèmes et Applications des Technologies de l'Information et de l'Energie (SATIE), Université Paris-Seine-Université Paris-Seine-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Centre National de la Recherche Scientifique (CNRS), Département Composants et Systèmes (IFSTTAR/COSYS), and PRES Université Lille Nord de France-PRES Université Nantes Angers Le Mans (UNAM)-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)

Subjects
Computer science, 020209 energy, Overhead (engineering), CHARGING INFRASTRUCTURE, Context (language use), 02 engineering and technology, Track (rail transport), 7. Clean energy, Road transport, EV charging infrastructure, WIRELESS CHARGING, Electrification, 11. Sustainability, 0202 electrical engineering, electronic engineering, information engineering, WIRELESS POWER TRANSFER, INSTRUMENTATION, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Wireless power transfer, Instrumentation (computer programming), business.industry, [SPI.NRJ]Engineering Sciences [physics]/Electric power, 020208 electrical & electronic engineering, Electrical engineering, DEMONSTRATION, Automotive Engineering, electric road, business, ELECTRIC ROAD SYSTEM, INDUCTIVE POWER TRANSFER, VEHICULE ELECTRIQUE, Alternative technology
Abstract

In a context of growing electrification of road transport, Wireless Power Transfer (WPT) appears as an appealing alternative technology as it enables Electric Vehicles (EVs) to charge while driving and without any mechanical contact (with overhead cables or rails in the ground). Although the WPT technology background dates from the end of 20th century, recent advances in semiconductor technologies have enabled the first real demonstrations. Within the FABRIC European project, the French research Institute VEDECOM and its partners implemented a whole prototype wireless power transfer charging infrastructure. The first demonstrations of Inductive WPT in different real driving conditions (up to 20 kW, from 0 to 100 km/h, with one or two serial vehicles) were provided. This paper describes the prototype equipment and its instrumentation and provides the system characterization results. The future of the Inductive WPT technology is further discussed considering its different technical and economic challenges. In parallel, how this technology could be part of future generation road infrastructures is discussed. Future research and demonstration steps are presented in the conclusion.

Published
2019

5. Systematic Screening for Occupational Exposures in Lung Cancer Patients: A Prospective French Cohort

Author

Barbara Charbotel, Frédéric Gomez, Géraldine Lauridant, Sandrine Bonnand, Lionel Perrier, Olivia Pérol, Maurice Pérol, Virginie Avrillon, Paul Rebattu, Béatrice Fervers, Elodie Belladame, Centre Léon Bérard [Lyon], Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, medicine.medical_specialty, Lung Neoplasms, Health, Toxicology and Mutagenesis, lcsh:Medicine, occupational exposures, Article, 03 medical and health sciences, 0302 clinical medicine, cost analysis, Occupational Exposure, Surveys and Questionnaires, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Lung cancer, Referral and Consultation, ComputingMilieux_MISCELLANEOUS, Aged, business.industry, lcsh:R, Public Health, Environmental and Occupational Health, Middle Aged, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, medicine.disease, 3. Good health, social deprivation, Occupational Diseases, lung cancer, Social deprivation, Socioeconomic Factors, systematic self-administered questionnaire, 030220 oncology & carcinogenesis, Emergency medicine, Cohort, Carcinogens, Cost analysis, Female, Medical certificate, Occupational exposure, business
Abstract

Occupational lung cancers are under-reported and under-compensated worldwide. We assessed systematic screening for occupational exposure to carcinogens combining a self-administered questionnaire and an occupational consultation to improve the detection of occupational lung cancers and their compensation. Social deprivation and the costs of this investigation were estimated. Patients with lung cancer received a self-administered questionnaire to collect their job history, potential exposure to carcinogens and deprivation. A physician assessed the questionnaire and recommended an occupational consultation if necessary. During the consultation, a physician assessed if the lung cancer was work-related and, if it was, delivered a medical certificate to claim for compensation. Over 18 months, 440 patients received the self-administered questionnaire: 234 returned a completed questionnaire and a consultation was required for 120 patients. Compensation was judged possible for 41 patients. Among the 35 medical certificates delivered, 19 patients received compensation. Nearly half the patients (46%) were assessed as socially deprived and these patients took significantly longer to return the questionnaire compared with those who were not deprived. The mean cost of the process was €62.65 per patient. Our results showed a systematic self-administered questionnaire can be used to identify patients potentially exposed to carcinogens and to improve compensation.

Published
2018

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