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Your search keyword '"Wolfs, Tim G. A. M."' showing total 7 results
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7 results on '"Wolfs, Tim G. A. M."'

1. Antenatal Ureaplasma Infection Causes Colonic Mucus Barrier Defects: Implications for Intestinal Pathologies

Author

van Gorp, Charlotte, primary, de Lange, Ilse H., additional, Hütten, Matthias C., additional, López-Iglesias, Carmen, additional, Massy, Kimberly R. I., additional, Kessels, Lilian, additional, Knoops, Kèvin, additional, Cuijpers, Iris, additional, Sthijns, Mireille M. J. P. E., additional, Troost, Freddy J., additional, van Gemert, Wim G., additional, Spiller, Owen B., additional, Birchenough, George M. H., additional, Zimmermann, Luc J. I., additional, and Wolfs, Tim G. A. M., additional

Published
2024
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3. Hypoxia-Driven Changes in a Human Intestinal Organoid Model and the Protective Effects of Hydrolyzed Whey

Author

de Lange, Ilse H., primary, van Gorp, Charlotte, additional, Massy, Kimberly R. I., additional, Kessels, Lilian, additional, Kloosterboer, Nico, additional, Bjørnshave, Ann, additional, Stampe Ostenfeld, Marie, additional, Damoiseaux, Jan G. M. C., additional, Derikx, Joep P. M., additional, van Gemert, Wim G., additional, and Wolfs, Tim G. A. M., additional

Published
2023
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5. Intestinal Goblet Cell Loss during Chorioamnionitis in Fetal Lambs: Mechanistic Insights and Postnatal Implications

Author

van Gorp, Charlotte, primary, de Lange, Ilse H., additional, Massy, Kimberly R. I., additional, Kessels, Lilian, additional, Jobe, Alan H., additional, Cleutjens, Jack P. M., additional, Kemp, Matthew W., additional, Saito, Masatoshi, additional, Usada, Haruo, additional, Newnham, John, additional, Hütten, Matthias, additional, Kramer, Boris W., additional, Zimmermann, Luc J., additional, and Wolfs, Tim G. A. M., additional

Published
2021
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6. Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols

Author

van Gorp, Charlotte, primary, de Lange, Ilse H., additional, Spiller, Owen B., additional, Dewez, Frédéric, additional, Cillero Pastor, Berta, additional, Heeren, Ron M. A., additional, Kessels, Lilian, additional, Kloosterboer, Nico, additional, van Gemert, Wim G., additional, Beeton, Michael L., additional, Stock, Sarah J., additional, Jobe, Alan H., additional, Payne, Matthew S., additional, Kemp, Matthew W., additional, Zimmermann, Luc J., additional, Kramer, Boris W., additional, Plat, Jogchum, additional, and Wolfs, Tim G. A. M., additional

Published
2019
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7. Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.

Author

Gussenhoven R, Klein L, Ophelders DRMG, Habets DHJ, Giebel B, Kramer BW, Schurgers LJ, Reutelingsperger CPM, and Wolfs TGAM

Abstract

Blood-brain barrier (BBB) disruption is associated with hypoxia-ischemia (HI) induced brain injury and life-long neurological pathologies. Treatment options are limited. Recently, we found that mesenchymal stem/stromal cell derived extracellular vesicles (MSC-EVs) protected the brain in ovine fetuses exposed to HI. We hypothesized that Annexin A1 (ANXA1), present in MSC-EVs, contributed to their therapeutic potential by targeting the ANXA1/Formyl peptide receptor (FPR), thereby preventing loss of the BBB integrity. Cerebral ANXA1 expression and leakage of albumin into the fetal ovine brain parenchyma after HI were analyzed by immunohistochemistry. For mechanistic insights, barrier integrity of primary fetal endothelial cells was assessed after oxygen-glucose deprivation (OGD) followed by treatment with MSC-EVs or human recombinant ANXA1 in the presence or absence of FPR inhibitors. Our study revealed that BBB integrity was compromised after HI which was improved by MSC-EVs containing ANXA1. Treatment with these MSC-EVs or ANXA1 improved BBB integrity after OGD, an effect abolished by FPR inhibitors. Furthermore, endogenous ANXA1 was depleted within 24 h after induction of HI in cerebovasculature and ependyma and upregulated 72 h after HI in microglia. Targeting ANXA1/FPR with ANXA1 in the immature brain has great potential in preventing BBB loss and concomitant brain injury following HI.

Published
2019
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