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Idiopathic pulmonary fibrosis (IPF) is a chronic and age-related lung disease that has few treatment options. Reactive oxygen species (ROS) play an important role in the introduction and development of IPF. In the present study, we developed multifunctional Cobalt (Co)–Manganese (Mn) complex oxide nanoparticles (Co-MnNPs), which can scavenge multiple types of ROS. Benefiting from ROS scavenging activities and good biosafety, Co-MnNPs can suppress canonical and non-canonical TGF-β pathways and, thus, inhibit the activation of fibroblasts and the productions of extracellular matrix. Furthermore, the scavenging of ROS by Co-MnNPs reduce the LPS-induced expressions of pro-inflammatory factors in macrophages, by suppressing NF-κB signaling pathway. Therefore, Co-MnNPs can reduce the excessive extracellular matrix deposition and inflammatory responses in lungs and, thus, alleviate pulmonary fibrosis induced by bleomycin (BLM) in mice. Taken together, this work offers an anti-fibrotic agent for treatment of IPF and other ROS-related diseases.

Due to the working principle of MEMS resonant accelerometers, their thermally induced frequency drift is an inevitable practical issue for their extensive application. This paper is focused on reducing the thermally induced packaging effects on the frequency drift. A leadless ceramic chip carrier package with a stress-buffering layer was proposed for a MEMS resonant accelerometer, and the influences of packaging structure parameters on the frequency drift were investigated through finite element simulations and verified experimentally. Because of the thermal mismatch between dissimilar materials, the thermo-mechanical stress within the resonant beam leads to a change in the effective stiffness and causes the frequency drift to decrease linearly with increasing temperature. Furthermore, our investigations reveal that increasing the stress-buffering layer thickness and reducing the solder layer thickness can significantly minimize the thermo-mechanical stress within the resonant beam. As the neutral plane approaches the horizontal symmetry plane of the resonant beam when optimizing the packaging structure, the effects of the compressive and tensile stresses on the effective stiffness of the resonant beam will cancel each other out, which can dramatically reduce the frequency drift. These findings provide guidelines for packaging design through which to improve the temperature stability of MEMS resonant accelerometers.

An MEMS resonant accelerometer is a temperature-sensitive device because temperature change affects the intrinsic resonant frequency of the inner silicon beam. Most classic temperature compensation methods, such as algorithm modeling and structure design, have large errors under rapid temperature changing due to the hysteresis of the temperature response of the accelerometer. To address this issue, we propose a novel reservoir computing (RC) structure based on a nonlinear silicon resonator, which is specifically improved for predicting dynamic information that is referred to as the input–output-improved reservoir computing (IOI-RC) algorithm. It combines the polynomial fitting with the RC on the input data mapping ensuring that the system always resides in the rich nonlinear state. Meanwhile, the output layer is also optimized by vector concatenation operation for higher memory capacity. Therefore, the new system has better performance in dynamic temperature compensation. In addition, the method is real-time, with easy hardware implementation that can be integrated with MEMS sensors. The experiment’s result showed a 93% improvement in IOI-RC compared to raw data in a temperature range of −20–60 °C. The study confirmed the feasibility of RC in realizing dynamic temperature compensation precisely, which provides a potential real-time online temperature compensation method and a sensor system with edge computing.

In this paper, we demonstrate a novel photonic integrated accelerometer based on the optical mode localization sensing mechanism, which is designed on an SOI wafer with a device layer thickness of 220 nm. High sensitivity and large measurement range can be achieved by integrating coupled ring resonators with a suspended directional coupler on a proof mass. With the help of FEA simulation and numerical analysis, the proposed optical mode-localized sensor presents a sensitivity of 10/g (modal power ratio/acceleration) and an inertial displacement of from −8 to 10 microns corresponding to a range from −23.5 to 29.4 g. The free spectral range is 4.05 nm around 1.55 microns. The acceleration resolution limited by thermomechanical noise is 4.874 μg. The comprehensive performance of this design is competitive with existing MEMS mode localized accelerometers. It demonstrates the potential of the optical mode-localized inertial sensors as candidates for state-of-the-art sensors in the future.

A mode-localized ΔE-effect magnetic sensor model is established theoretically and numerically. Based on the designed weakly coupled resonators with multi-layer film structure, it is investigated how the ΔE-effect of the magnetostrictive film under the external magnetic field causes the stiffness perturbation of the coupled resonators to induce the mode localization effect. Using the amplitude ratio (AR) as the output in the mode-localized ΔE-effect magnetic sensor can improve the relative sensitivity by three orders of magnitude compared with the traditional frequency output, which has been verified by simulations based on the finite element method (FEM). In addition, the effects of material properties and geometric dimensions on sensor performance parameters, such as sensitivity, linear range, and static operating point are also analyzed and studied in detail, providing the theoretical basis for the design and optimization of the mode-localized ΔE-effect magnetic sensor in different application scenarios. By reasonably optimizing the key parameters of the weekly coupled resonators, a mode-localized ΔE-effect magnetic sensor with the sensitivity of 18 AR/mT and a linear range of 0.8 mT can be achieved.

Reservoir computing (RC) is a potential neuromorphic paradigm for physically realizing artificial intelligence systems in the Internet of Things society, owing to its well-known low training cost and compatibility with nonlinear devices. Micro-electro-mechanical system (MEMS) resonators exhibiting rich nonlinear dynamics and fading behaviors are promising candidates for high-performance hardware RC. Previously, we presented a non-delay-based RC using one single micromechanical resonator with hybrid nonlinear dynamics. Here, we innovatively introduce a nonlinear tuning strategy to analyze the computing properties (the processing speed and recognition accuracy) of the presented RC. Meanwhile, we numerically and experimentally analyze the influence of the hybrid nonlinear dynamics using the image classification task. Specifically, we study the transient nonlinear saturation phenomenon by fitting quality factors under different vacuums, as well as searching the optimal operating point (the edge of chaos) by the static bifurcation analysis and dynamic vibration numerical models of the Duffing nonlinearity. Our results in the optimal operation conditions experimentally achieved a high classification accuracy of (93 ± 1)% and several times faster than previous work on the handwritten digits recognition benchmark, profit from the perfect high signal-to-noise ratios (quality factor) and the nonlinearity of the dynamical variables.

Reservoir computing (RC) is an attractive paradigm of a recurrent neural network (RNN) architecture, owning to the ease of training and existing neuromorphic implementation. Its simulated performance matches other digital algorithms on a series of benchmarking tasks, such as prediction tasks and classification tasks. In this article, we propose a novel RC structure based on the coupled MEMS resonators with the enhanced dynamic richness to optimize the performance of the RC system both on the system level and data set level. Moreover, we first put forward that the dynamic richness of RC comprises linear dynamic richness and nonlinear dynamic richness, which can be enhanced by adding delayed feedbacks and nonlinear nodes, respectively. In order to set forth this point, we compare three typical RC structures, a single-nonlinearity RC structure with single-feedback, a single-nonlinearity RC structure with double-feedbacks, and the couple-nonlinearity RC structure with double-feedbacks. Specifically, four different tasks are enumerated to verify the performance of the three RC structures, and the results show the enhanced dynamic richness by adding delayed feedbacks and nonlinear nodes. These results prove that coupled MEMS resonators offer an interesting platform to implement a complex computing paradigm leveraging their rich dynamical features.

Non-contact and non-destructive acceleration measurement is receiving considerable attention due to their low cost, flexibility, and simplicity of implementation, as well as their excellent performance in some emerging applications such as medical electronics applications, vibration monitoring, and some other special scenarios. In this paper, a visual accelerometer system based on laser speckle optical flow detection named Viaxl is proposed. Compared with the conventional non-contact acceleration measurement method based on a laser system, Viaxl has moderate and stable performance with the advantages of low cost and simplicity of implementation. Experiment results demonstrate that Viaxl, which consists of a commercial camera and a low-cost laser pointer, can achieve real-time, non-contact acceleration measurement, and confirm the basic system performance of Viaxl: a measurement nonlinearity better than 1.3%, up to 31 dB signal-to-noise ratio, and 1150 Hz theoretic bandwidth; this demonstrates the huge potential of Viaxl in a wide range of applications, and provides a new possible technical method for non-contact acceleration detection.