1. Secondary Metabolites from Marine-Derived Fungus Penicillium rubens BTBU20213035
- Author
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Xiuli Xu, Yifei Dong, Jinpeng Yang, Long Wang, Linlin Ma, Fuhang Song, and Xiaoli Ma
- Subjects
marine-derived fungus ,Penicillium rubens ,polyketide ,bis-tetrahydrofuran ,antibacterial ,synergistic antifungal ,Biology (General) ,QH301-705.5 - Abstract
Two new polyketide derivatives, penirubenones A and B (1 and 2), and two naturally rare amino-bis-tetrahydrofuran derivatives, penirubenamides A and B (3 and 4), together with nine known compounds (5–13) were isolated from the marine-derived fungus Penicillium rubens BTBU20213035. The structures were identified by HRESIMS and 1D and 2D NMR analyses, and their absolute configurations were determined by a comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy and 13C NMR data. We found that 6 exhibited antibacterial activity against Staphylococcus aureus, with an MIC value of 3.125 μg/mL, and 1 and 2 showed synergistic antifungal activity against Candida albicans at 12.5 and 50 μg/mL with 0.0625 μg/mL rapamycin.
- Published
- 2024
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