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Organophosphorus compounds (OPs) are widely used and have the potential to be harmful environmental toxicants to humans. Long non-coding RNA (lncRNA) plays a crucial regulatory role in cytotoxicity. This study aimed to investigate the effects of OPs on the expression of lncRNAs in cells. The effects of the industrial OPs TNPP and TCPP on both CYTOR and cellular viability were examined in the following human renal cell lines: HEK293T and HK-2. Both TCPP and TNPP downregulated CYTOR expression, increased reactive oxygen species levels, and induced apoptosis; the upregulated expression of CYTOR resulted in a reduction in apoptosis. The results of the luciferase reporter assay and the knock-down assay indicate that CEBPA binds to the upstream promoter region of CYTOR and regulates its transcription. Furthermore, TCPP and TNPP were found to downregulate the phosphorylation of ERK in the signaling pathway that is upstream of CEBPA. These results indicate that TCPP and TNPP can decrease the level of CEBPA by reducing ERK phosphorylation; this leads to a decrease in CYTOR expression, which further promotes cellular reactive oxygen species and apoptosis. Therefore, the ERK/CEBPA/CYTOR axis is one of the pathways by which organophosphates produce cytotoxicity, leading to renal cell injury. This study presents evidence for both the abnormal expression of lncRNA that is caused by organophosphates and the regulatory function of lncRNA regarding downstream cellular viability.

Forest management, especially understory vegetation conversion, significantly affects soil greenhouse gas (GHG) emissions and soil C and N pools. However, it remains unclear what effect renovating understory vegetation has on GHG emissions and soil C and N pools in plantations. This study investigates the impact of renovating understory vegetation on these factors in Chinese hickory (Carya cathayensis Sarg) plantation forests. Different understory renovation modes were used in a 12-month field experiment: a safflower camellia (SC) (Camellia chekiangoleosa Hu) planting density of 600 plants ha−1 and wild rape (WR) (Brassica napus L.) strip sowing (UM1); SC 600 plants ha−1 and WR scatter sowing (UM2); SC 1200 plants ha−1 and WR strip sowing (UM3); SC 1200 plants ha−1 and WR scatter sowing (UM4); and removal of the understory vegetation layer (CK). The results showed that understory vegetation modification significantly increased soil CO2 and emission fluxes and decreased soil CH4 uptake fluxes (p < 0.01). The understory vegetation transformation significantly improved soil labile carbon and labile nitrogen pools (p < 0.01). This study proposes that understory vegetation conversion can bolster soil carbon sinks, preserve soil fertility, and advance sustainable development of Chinese hickory plantation forests.

Known as the “Asian Water Tower”, the Tibetan Plateau (TP) is a rich water resource and serves an important ecological function. Climate change may cause changes to the water cycle, and these changes may affect the alpine vegetation growth. However, the variation characteristics of groundwater storage (GWS) and its driving factors and associated ecological effects in the TP are poorly understood. In this study, terrestrial water storage changes retrieved by GRACE (Gravity Recovery and Climate Experiment) were combined with GLDAS (Global Land Data Assimilation System) to estimate the GWS changes in the TP. The temporal and spatial variation characteristics of GWS were identified using linear regression and the modified Mann–Kendall (MMK) test, respectively. The analyses showed that the GWS of the TP decreased at an average rate of −0.89 mm/a from January 2003 to December 2021, but since January 2016, it gradually recovered at a rate of 1.47 mm/a. This shows that the GWS in the eastern and northern parts of the TP is decreasing, while the GWS in the western and southern parts is increasing. The influence of climate change on GWS in time and space was determined using the correlation analysis method. Decreased precipitation and permafrost degradation caused by increasing temperatures will lead to a decrease in GWS. On the other hand, rising temperatures may result in an increase in GWS in regions where glaciers are distributed. In this study, the ecological effects were represented by the relationship between GWS and vegetation change. A decline in GWS means that the vegetation will not receive enough water, leading to a decrease in the NDVI and the eventual degradation of grassland to sand, desert, or other kinds of unused land on the TP. On the other hand, an increase in GWS would promote vegetation restoration. The results of this study offer a new opportunity to reveal the groundwater changes in a cryosphere region and to assess the impact of changes in hydrological conditions on ecology.

Groundwater is an important source of drinking water, particularly in arid regions. In this study, a total of 66 groundwater samples were collected from the phreatic aquifer in the Shizuishan area, a traditional irrigation region of Ningxia. The results showed that the TDS values were above the drinking water standards for nearly 50% of the groundwater samples. The ions followed the order of Na+ > Ca2+ > Mg2+ > K+ and SO42− > Cl− > HCO3− in the groundwater. There were four dominant factors in controlling groundwater chemistry based on principal component analysis: the salinity factor, alkalinity factor, carbonate factor, and pollution factor. The high concentration of NH4-N in groundwater was attributed to agricultural activities, but the high NO3-N levels were mainly due to sewage or wastewater. F and As were derived from geogenic sources. Based on the result of the WQI assessment, about 40% of the samples in the central part of the study region showed unacceptable water quality for drinking, which was mainly associated with high NH4-N, TDS, and As concentrations. The total non-carcinogenic risks of drinking the groundwater were 0.05–10.62 for adults and 0.09–20.65 for children, respectively. The order of pollutants in the groundwater in terms of their hazard to residents was: As > F− > NO3-N > NH4-N. The carcinogenic risk values of As through oral ingestion for children and adults were 0–7.37 × 10−4 and 0–1.89 × 10−4, respectively. Chronic exposure by oral ingestion presented as the main source of susceptibility to exposure to groundwater contaminants for children.

Mitochondria are the sites of oxidative metabolism in eukaryotes where the metabolites of sugars, fats, and amino acids are oxidized to harvest energy. Notably, mitochondria store Ca2+ and work in synergy with organelles such as the endoplasmic reticulum and extracellular matrix to control the dynamic balance of Ca2+ concentration in cells. Mitochondria are the vital organelles in heart tissue. Mitochondrial Ca2+ homeostasis is particularly important for maintaining the physiological and pathological mechanisms of the heart. Mitochondrial Ca2+ homeostasis plays a key role in the regulation of cardiac energy metabolism, mechanisms of death, oxygen free radical production, and autophagy. The imbalance of mitochondrial Ca2+ balance is closely associated with cardiac remodeling. The mitochondrial Ca2+ uniporter (mtCU) protein complex is responsible for the uptake and release of mitochondrial Ca2+ and regulation of Ca2+ homeostasis in mitochondria and consequently, in cells. This review summarizes the mechanisms of mitochondrial Ca2+ homeostasis in physiological and pathological cardiac remodeling and the regulatory effects of the mitochondrial calcium regulatory complex on cardiac energy metabolism, cell death, and autophagy, and also provides the theoretical basis for mitochondrial Ca2+ as a novel target for the treatment of cardiovascular diseases.

Underground coal fires can increase surface temperature, cause surface cracks and collapse, and release poisonous and harmful gases, which significantly harm the ecological environment and humans. Traditional methods of extracting coal fires, such as global threshold, K-mean and active contour model, usually produce many false alarms. Therefore, this paper proposes an improved active contour model by introducing the distinguishing energies of coal fires and others into the traditional active contour model. Taking Urumqi, Xinjiang, China as the research area, coal fires are detected from Landsat-8 satellite and unmanned aerial vehicle (UAV) data. The results show that the proposed method can eliminate many false alarms compared with some traditional methods, and achieve detection of small-area coal fires by referring field survey data. More importantly, the results obtained from UAV data can help identify not only burning coal fires but also potential underground coal fires. This paper provides an efficient method for high-precision coal fire detection and strong technical support for reducing environmental pollution and coal energy use.

Understanding the propagation of landslide-generated water waves is of great help against tsunami hazards. In order to investigate the effects of landslide shapes on the far-field leading wave generated by a submerged landslide at a constant depth, three linear wave models with different degrees of dispersive properties are employed in this study. The linear fully dispersive model is then validated by comparing the results against the experimental data available for landslides with a low Froude number. Three simplified shapes of landslides with the same volume, which are unnatural for a body of incoherent material, are used to investigate the effects of landslide shapes on the far-field properties of the generated leading wave over a flat seabed. The results show that the far-field leading crest over a constant depth is independent of the exact landslide shape and is invalid at a shallow water depth. Therefore, the most popular non-dispersive model (also called the shallow water wave model) cannot be used to reproduce the phenomenon. The weakly dispersive wave model can predict this phenomenon well. If only the leading wave is considered, this model is accurate up to at least μ = h0/Lc = 0.6, where h0 is the water depth and Lc denotes the characteristic length of the landslide.

Knowledge of hydrochemical processes in groundwater helps to identify the relationship between geochemical processes and groundwater quality as well as to understand the hydrochemical evaluation of groundwater, which is important for the sustainable management of groundwater resources. This study aims to identify the chemical characteristics of groundwater in the area of Tongchuan City, China. A total of 58 groundwater samples were collected. A hierarchical cluster analysis divided samples into three clusters and six sub-clusters (cluster 1a, 1b, 2a, 2b, 3a, 3b) according to hydrochemical facies. Graphical plots of multiple ionic ratios, saturation indices, and ion exchange indices were employed to examine hydrochemical processes that result in different hydrochemical facies of each cluster. Results show the predominance of carbonate and silicate weathering in cluster 1, silicate weathering in cluster 2, and carbonate weathering in cluster 3. Ionic exchange is a ubiquitous process among all clusters. The distribution of clusters is related to the regional geology, which may result in different hydrochemical processes. Two stratigraphic sections identify the differences in hydrochemical processes resulting from complex stratum structures and varied aquifer media. Cluster 2a shows an interesting difference in water chemistry along the groundwater flow path. Further study by oxygen and hydrogen isotope indicated that mixing between Quaternary and the Permian aquifers resulting from faulting is the main reason for the distinctive characteristic of cluster 2a.