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Influenza A virus (IAV) infection initiates a complex interplay of cell death modalities, including apoptosis, necroptosis, pyroptosis, and their integration, known as PANoptosis, which significantly impacts host immune responses and tissue integrity. These pathways are intricately regulated by viral proteins and host factors, contributing to both viral clearance and pathogenesis-related tissue damage. This review comprehensively explores the molecular mechanisms underlying these cell death processes in influenza infection. We highlight the roles of key regulatory proteins, such as ZBP1 (Z-DNA binding protein 1) and RIPK3 (receptor-interacting protein kinase 3), in orchestrating these responses, emphasizing the dual roles of cell death in both antiviral defense and tissue injury. Furthermore, we discuss emerging therapeutic strategies targeting these pathways, aiming to enhance antiviral efficacy while minimizing collateral tissue damage. Future research should focus on targeted approaches to modulate cell death mechanisms, aiming to reduce tissue damage and improve clinical outcomes for patients with severe influenza.

Blockchain is widely used in the manufacturing industry. This paper establishes a dual-channel supply chain composed of a manufacturer and an e-retailer. A monopoly manufacturer conducts indirect online selling through retailers as well as direct offline selling. The manufacturer chooses to adopt a self-built blockchain traceability system (SBT) or a third-party blockchain traceability system (TBT). Game analysis is developed to depict the pricing decision for the manufacturer and e-retailer. The optimal pricing decisions of the supply chain between manufacturer and e-retailer for different blockchain traceability strategies are obtained. We explore the influence of consumers’ traceability awareness on the decisions of dual-channel supply chain members when adopting different blockchain traceability strategies. The main results show that when the fee paid to the blockchain service provider is low, the manufacturer will prefer to adopt TBT. Moreover, we prove that consumers’ traceability awareness, the cost of adopting TBT, the blockchain traceability technology level, and the research and development cost factor of blockchain technology could affect the decisions of supply chain members. Finally, some management suggestions are provided.

Blockchain technology allows fresh agricultural enterprises to share records stored on the chain, and the technology can benefit information management systems, such as decentralization and transparency. This study uses game theory to examine a blockchain introduction strategy for fresh agricultural enterprises in a competitive environment, considering consumer traceability preferences. We establish a pricing decision model in traditional and blockchain traceability modes and identify optimal solutions. Additionally, we analyze the impact of the blockchain introduction strategy, consumer preferences, and blockchain influence factor on optimal pricing decisions. The results indicate that the introduction of blockchain could improve the profits of enterprises under certain conditions. Moreover, consumer traceability preferences and the blockchain influence factor could significantly affect the blockchain introduction strategy. We also discover that when the blockchain influence factor meets a certain range, introducing blockchain technique in the traceability system could shift demand from traditional enterprises to blockchain enterprises. The total market demand for blockchain enterprises under the blockchain traceability mode will increase, whereas that of traditional enterprises under the blockchain traceability mode will decrease. Both consumer traceability preferences and the blockchain influence factor could significantly affect optimal pricing. Finally, some management suggestions are provided for the traceability of fresh agricultural enterprises based on the research conclusions.

As China’s second largest energy-use sector, residential consumption has a great potential for carbon dioxide (CO2) reduction and energy saving or transition. Thus, here, using the methods of social network analysis (SNA) and geographically weighted regression (GWR), we investigated the spatiotemporal evolution characteristics of China’s residential CO2 emissions (RCEs) from direct energy use and proposed some policy suggestions for regional energy transition. (1) From 2000 to 2019, the total direct RCEs rose from 396.32 Mt to 1411.69 Mt; the consumption of electricity and coal were the primary sources. Controlling coal consumption and increasing the proportion of electricity generated from renewable energy should be the effective way of energy transition. (2) The spatial associations of direct RCEs show an obvious spatial network structure and the number of associations is increasing. Provinces with a higher level of economic development (Beijing, Shanghai, and Jiangsu) were at the center of the network and classified as the net beneficiary cluster in 2019. These provinces should be the priority areas of energy transition. (3) The net spillover cluster (Yunnan, Shanxi, Xinjiang, Gansu, Qinghai, Guizhou) is an important area to develop clean energy. People in this cluster should be encouraged to use more renewable energy. (4) GDP and per capita energy consumption had a significant positive influence on the growth of direct RCEs. Therefore, the national economy should grow healthily and sustainably to provide a favorable economic environment for energy transition. Meanwhile, residential consumption patterns should be greener to promote the use of clean energy.