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Your search keyword '"Zhang, Fangyuan"' showing total 17 results
Start Over Author "Zhang, Fangyuan" Publisher mdpi ag
17 results on '"Zhang, Fangyuan"'

15. The Novel Autophagy Inhibitor Alpha-Hederin Promoted Paclitaxel Cytotoxicity by Increasing Reactive Oxygen Species Accumulation in Non-Small Cell Lung Cancer Cells

Author

Zhan, Yujuan, primary, Wang, Kun, additional, Li, Qiao, additional, Zou, Yidan, additional, Chen, Bonan, additional, Gong, Qing, additional, HO, Hiuting, additional, Yin, Ting, additional, Zhang, Fangyuan, additional, Lu, Yuhua, additional, Wu, Weijie, additional, Zhang, Yilin, additional, Tan, Yuhui, additional, Du, Biaoyan, additional, Liu, Xiaodong, additional, and Xiao, Jianyong, additional

Published
2018
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17. Comparative Gene Expression Analysis of Salmonella Typhimurium DT104 in Ground Chicken Extract and Brain Heart Infusion Broth.

Author

Liu Y, Zhang F, Hawkins JL, Elder JR, Baranzoni GM, Huang Z, Fratamico PM, and Parveen S

Abstract

Salmonella enterica Typhimurium DT104 ( S. Typhimurium DT104) is an important foodborne pathogen that is associated with poultry and poultry products. Currently, there is very little information on the underlying molecular mechanisms that allow DT104 to survive and propagate in poultry meat and the poultry processing environment. The current study assessed the global gene expression of DT104 in ground chicken extract (GCE) compared to brain heart infusion (BHI) medium using RNA-Seq technology. DT104 was grown to the early stationary phase (ESP), inoculated into GCE or BHI, and then re-grown to the log phase before RNA was extracted and transcripts were quantified by RNA-Seq. Gene expression for DT104 grown in GCE was then compared to that of DT104 grown in BHI for samples grown to the ESP. Growth in GCE resulted in the up-regulated expression of genes related to translation, carnitine metabolism (23-283-fold change), and cobalamin (vitamin B12) biosynthesis (14-fold change). In particular, the presence of carnitine in chicken meat, and thus, in GCE, which lacks carbohydrates, may allow Salmonella to utilize this compound as a carbon and nitrogen source. This study demonstrates that RNA-Seq data can provide a comprehensive analysis of DT104 gene expression in a food model for poultry products. This study also provides additional evidence for the importance of metabolic adaptation in the ability of S. enterica to successfully adapt to and occupy niches outside of its host and provides potential targets that could be used to develop intervention strategies to control Salmonella in poultry.

Published
2024
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