1. Novel DSP Spectrin 6 Region Variant Causes Neonatal Erythroderma, Failure to Thrive, Severe Herpes Simplex Infections and Brain Lesions.
- Author
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VAKKILAINEN, Svetlana, PUHAKKA, Laura, KLEMETTI, Paula, HEISKANEN, Kaarina, SEPPÄNEN, Mikko, MUONA, Mikko, POSSEME, Celine, DUFFY, Darragh, VÄISÄNEN, Timo, ELOMAA, Outi, PALOMÄKI, Maarit, SAXÉN, Harri, RANKI, Annamari, and HANNULA-JOUPPI, Katariina
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PALMOPLANTAR keratoderma , *HERPES simplex , *BRAIN damage , *SPECTRIN , *IMMUNOGLOBULIN E , *HERPES simplex virus - Abstract
Desmoplakin (DSP) and Desmoglein 1 (DSG1) variants result in skin barrier defects leading to erythroderma, palmoplantar keratoderma and variable other features. Some DSG1 variant carriers present with SAM syndrome (Severe dermatitis, multiple Allergies, Metabolic wasting) and a SAM-like phenotype has been reported in 4 subjects with different heterozygous DSP variants. We report here a patient with a novel DSP spectrin region (SR) 6 variant c.1756C>T, p.(His586Tyr), novel features of brain lesions and severe recurrent mucocutaneous herpes simplex virus infections, with a favourable response to ustekinumab. Through a review of reported cases of heterozygous variants in DSP SR6 (n = 15) and homozygous or compound heterozygous variants in DSG1 (n = 12) and SAM-like phenotype, we highlight phenotypic variability. Woolly hair, nail abnormalities and cardiomyopathy characterize patients with DSP variants, while elevated immunoglobulin E and food allergies are frequent in patients with DSG1 variants. Clinicians should be aware of the diverse manifestations of desmosomopathies. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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