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E-mail: antonella.cherubini@ass1.sanita.fvg.it Background: From the literature we know that less than 50% of patients with coronary artery disease (CAD) reaches the target LDL cholesterol 75 yo 42% vs 46%, p=0,002), had more cardiovascular (CV) risk factors, comorbidities (Charlson index >5) and statins prescription (70% vs 61%), but less frequent stroke or TIA. In the group with LDL available, CARDIOVASCULAR PREVENTION and REHABILITATION

Purpose: Chronic kidney disease with renal dysfunction (RD) is associated with an increased risk of thromboembo- lic and hemorrhagic events in non-valvular atrial fibrillation (NVAF). Although the current European Guidelines on NVAF suggest that an accurate evaluation of the renal func- tion is useful in hemorrhagic risk stratification, it has not been yet considered in thromboembolic risk score CHA 2- DS2VASc. The aim of our study was to evaluate the prog- nostic role of RD in a wide "real world" population of NVAF outpatients. 2DS2VASc score was 4 (range 3-5) and ≥2 points in 91.1% of patients. During a median follow-up of 27 months, 531 (35%) deaths or CVH, 113 (7.5%) thromboem- bolic events and 24 (1.6%) major bleedings were recorded. The presence of RD identified a group of older patients with more cardiovascular (CV) risk factors, more severe heart disease, higher Charlson Index, more concomitant medical therapies. During the follow-up, we recorded 48% vs 30% of deaths or CVH (p