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Atopic dermatitis is an inflammatory skin disease, characterized by periods of exacerbation and remission, which affects 15-30% of children and 2-10% of adults. It is known that atopic dermatitis is caused by an abnormal skin barrier (physical, chemical and immunological). In addition, new studies have shown that an important role in the pathophysiology of atopic dermatitis is the altered skin microbiota. This review highlights the recent observations regarding the changes of the skin microbiome in atopic dermatitis and possible therapeutic options for this disease. [ABSTRACT FROM AUTHOR]

Hidradenitis suppurativa represents a chronic, recurrent inflammatory disease, characterized by the formation of painful abscesses, sinuous tracts, foul smelling secretions, vicious scaring, with a severe reduction of the patients' quality of life. The pathophysiology of hidradenitis suppurativa is complex, follicular hyperkeratosis being regarded as the main pathogenetic mechanism. Bacterial colonization and follicular dysbiosis are of secondary importance in the pathogenesis of the disease, by triggering immunemediated inflammation. The formation of bacterial biofilms in sinuous tracts inhibits the efficacy of antibiotics, thus inducing chronic lesions. This article aims to highlight the role of bacterial colonization in the pathophysiology of hidradenitis suppurativa, as well as therapeutic options that act by regulating follicular dysbiosis. [ABSTRACT FROM AUTHOR]

Acne vulgaris is a disorder of the pilosebaceous unit that affects approximately 85% of teenagers. There are multiple factors involved in the pathogenesis, among which an imbalance in the skin microbiota, with an increased representation of Cutibacterium (former Propionibacterium) acnes, that activates innate immunity and leads to chronic inflammation. This review highlights recent observations regarding the influence of different Cutibacterium acnes phylotypes in acne and the importance of antimicrobial resistance of acne-associated strains. [ABSTRACT FROM AUTHOR]