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The purpose of the study is to analyze the clinical, biological and therapeutic aspects, together with the evolution under therapy in Ludwig's angina, and the factors that determined the onset of this very severe disease. The retrospective study was done on a group of five adult patients with Ludwig's angina, admitted in the “Elias” University Emergency Hospital, during 2012 and 2016. All patients presented stomatological records or angina that became the portal of entry. The clinical manifestations of the onset were: high fever, local pains, trismus and regional painful tumefaction, or dysphagia and dyspnea. The diagnosis confirmation was realized through bacteriological exams and the treatment consisted in antibiotherapy associated with surgical drainage, soft tissue decompression, local periodontal therapy of the primary focus and corresponding pathogenic therapy. The response was favorable in all five cases. Conclusions. Ludwig's angina represents a very severe infection by its systemic potential and its etiologic and anatomic context, allowing the spread of the infection in the mediastinum, with direct effects on the respiratory and cardiac functions. [ABSTRACT FROM AUTHOR]